Shiloh
Editor, Senior Moderator
Source: http://www.cidrap.umn.edu/news-perspective/2017/06/stewardship-resistance-scan-jun-30-2017
Stewardship / Resistance Scan for Jun 30, 2017
Students' antibiotic knowledge; MCR-1 in Portugal
Filed Under:
MCR-1; Antimicrobial Stewardship; E coli
[h=3]Early education boosts students' antibiotic savvy, study finds[/h] A hands-on educational program dramatically increased primary school students' knowledge of antibiotic action and use, according to a study yesterday in the International Journal of Antimicrobial Agents.
The program involved scientific workshops at 26 primary schools in Turin, Italy, led by public health experts for more than 1,200 children aged 9 to 11 years. The project involved hands-on experiments, microscope observation, quizzes, interactive games, and team competitions. Course topics were: (1) introduction to microbes, (2) infection spread, (3) the immune system, (4) infection treatment, and (5) infection prevention. It was implemented for three school years from 2011 to 2015.
Students' responses on both antibiotic action and use improved significantly pre- and post-education. Before the program, only 5.0% of 956 students correctly agreed that antibiotics are effective against bacteria, while afterward the number rose to 77.2%. And before the program 75.8% incorrectly thought the drugs were effective against bacteria and viruses, and 19.1% incorrectly thought they were effective against all microorganisms. After the program those rates dropped to 12.8% and 10.0%, respectively.
Regarding antibiotic use, the percentage of students who correctly agreed with, "The unnecessary use of antibiotics can increase the resistance of bacteria to them" rose from 12.1% to 73.6% pre- and post-program, respectively. And those who incorrectly agreed with, "The use of antibiotics can speed up the recovery of cold, cough, and flu" dropped from 87.9% to 26.4%.
The authors conclude, "Although it is difficult to determine the true success of this project, due to the lack of data on long-term retention of knowledge and real behavior changes of students after being taught, data gathered support the idea that early childhood microbial literacy through a hands-on approach should contribute to engage students with scientific subjects and health-related issues."
Jun 29 Int J Antimicrob Agents study
[h=3]Portuguese researchers report MCR-1 in ICU patient[/h] Researchers in Portugal describe the detection of the colistin-resistance MCR-1 gene in Escherichia coli isolates from a patient who had been treated with meropenem and colistin, according to a report today in Emerging Infectious Diseases.
The patient, a 70-year-old woman, was admitted to intensive care last July for abdominal pain and received meropenem, fluconazole, and linezolid after emergency surgery for an abdominal occlusion. After 50 days of antibiotics, a urine specimen tested positive for Klebsiella pneumoniae, and further testing showed resistance to carbapenems but susceptibility to colistin and tigecycline, so she was prescribed colistin and tigecycline for 6 days, after which urine cultures were negative for K pneumoniae.
Six weeks later, however, E coli were isolated that showed a resistance profile identical to that of the previous K pneumoniae isolate but also expressing colistin resistance. In addition to the MCR-1 gene, the investigators confirmed the presence of the bla[SUB]KPC-3[/SUB] gene and other resistance genes.
The authors conclude, "Colistin-resistant [E coli] may have been part of the patient?s gut microbiome, acquiring the bla[SUB]KPC-3[/SUB]-encoding plasmid from the [K pneumoniae] strain. Although neutropenic, the patient's samples showed an asymptomatic bacteriuria. Thus, prophylactic administration of antibacterial drugs was likely avoidable."
Jun 30 Emerg Infect Dis report
Stewardship / Resistance Scan for Jun 30, 2017
Students' antibiotic knowledge; MCR-1 in Portugal
Filed Under:
MCR-1; Antimicrobial Stewardship; E coli
[h=3]Early education boosts students' antibiotic savvy, study finds[/h] A hands-on educational program dramatically increased primary school students' knowledge of antibiotic action and use, according to a study yesterday in the International Journal of Antimicrobial Agents.
The program involved scientific workshops at 26 primary schools in Turin, Italy, led by public health experts for more than 1,200 children aged 9 to 11 years. The project involved hands-on experiments, microscope observation, quizzes, interactive games, and team competitions. Course topics were: (1) introduction to microbes, (2) infection spread, (3) the immune system, (4) infection treatment, and (5) infection prevention. It was implemented for three school years from 2011 to 2015.
Students' responses on both antibiotic action and use improved significantly pre- and post-education. Before the program, only 5.0% of 956 students correctly agreed that antibiotics are effective against bacteria, while afterward the number rose to 77.2%. And before the program 75.8% incorrectly thought the drugs were effective against bacteria and viruses, and 19.1% incorrectly thought they were effective against all microorganisms. After the program those rates dropped to 12.8% and 10.0%, respectively.
Regarding antibiotic use, the percentage of students who correctly agreed with, "The unnecessary use of antibiotics can increase the resistance of bacteria to them" rose from 12.1% to 73.6% pre- and post-program, respectively. And those who incorrectly agreed with, "The use of antibiotics can speed up the recovery of cold, cough, and flu" dropped from 87.9% to 26.4%.
The authors conclude, "Although it is difficult to determine the true success of this project, due to the lack of data on long-term retention of knowledge and real behavior changes of students after being taught, data gathered support the idea that early childhood microbial literacy through a hands-on approach should contribute to engage students with scientific subjects and health-related issues."
Jun 29 Int J Antimicrob Agents study
[h=3]Portuguese researchers report MCR-1 in ICU patient[/h] Researchers in Portugal describe the detection of the colistin-resistance MCR-1 gene in Escherichia coli isolates from a patient who had been treated with meropenem and colistin, according to a report today in Emerging Infectious Diseases.
The patient, a 70-year-old woman, was admitted to intensive care last July for abdominal pain and received meropenem, fluconazole, and linezolid after emergency surgery for an abdominal occlusion. After 50 days of antibiotics, a urine specimen tested positive for Klebsiella pneumoniae, and further testing showed resistance to carbapenems but susceptibility to colistin and tigecycline, so she was prescribed colistin and tigecycline for 6 days, after which urine cultures were negative for K pneumoniae.
Six weeks later, however, E coli were isolated that showed a resistance profile identical to that of the previous K pneumoniae isolate but also expressing colistin resistance. In addition to the MCR-1 gene, the investigators confirmed the presence of the bla[SUB]KPC-3[/SUB] gene and other resistance genes.
The authors conclude, "Colistin-resistant [E coli] may have been part of the patient?s gut microbiome, acquiring the bla[SUB]KPC-3[/SUB]-encoding plasmid from the [K pneumoniae] strain. Although neutropenic, the patient's samples showed an asymptomatic bacteriuria. Thus, prophylactic administration of antibacterial drugs was likely avoidable."
Jun 30 Emerg Infect Dis report