https://www.cidrap.umn.edu/news-perspective/2022/06/stewardship-resistance-scan-jun-21-2022
Stewardship / Resistance Scan for Jun 21, 2022
Antimicrobial resistance and gender;
Burden, costs of complicated urinary tract infections
Filed Under:
Antimicrobial Stewardship
New project to explore connection between gender and antimicrobial resistance
Researchers in Africa and Asia have been selected to lead an upcoming research project that will explore the interconnections between antimicrobial resistance and gender.
The International Centre for Antimicrobial Resistance Solutions (ICARS) and the International Development Research Centre announced yesterday that the project will be led by South Africa's Human Sciences Research Council (HSRC), Jive Media Africa, and the Mahidol Oxford Tropical Medicine Research Unit (MORU) at Mahidol University in Thailand. The team will conduct systematic reviews, workshops, and interview with key experts to develop guidance for AMR research teams that are integrating gender into their work.
The ultimate aim of the guidance is to help strengthen the gender inclusiveness of AMR intervention and implementation research projects in low- and middle-income countries, particularly in sub-Saharan Africa and South Asia.
"We anticipate that this project will provide researchers with the necessary tools to capitalise on the potential of a gender lens to improve the quality, contextual relevance and impact of their AMR research," lead Investigators Ingrid Lynch of HSRC and Poy Naemiratch of MORU said in an ICARS news release.
The project is underway and will end in April 2023.
Jun 20 ICARS press release
Study finds frequent treatment failure for complicated urinary tract infections
An analysis of US health insurance data found frequent treatment failure in patients with complicated urinary tract infections (cUTIs), researchers reported yesterday in Open Forum Infectious Diseases.
Using data from two IBM MarketScan databases on privately insured and Medicare patients covering 2017 through 2019, researchers conducted a retrospective cohort study that looked at antibiotic treatment patterns, outcomes, and costs associated with cUTIs among adult patients, stratified by age (younger than 65 and 65 and over), over a 12-month follow-up period. Data from a recent US national database study indicates there are more than 2.8 million cUTI cases a year, but resistance to commonly used oral antibiotics is on the rise, and data on recurrent cUTIs is limited.
Among the 95,322 patients who met the study criteria, the initial setting of care was outpatient (OP) for 84%, and 87% were under 65 years of age. Treatment failure, which was defined as receipt a new unique OP antibiotic or a cUTI-related emergency department visit or hospital admission, occurred in 23% of OPs under 65 and 34% of those over 65, and over 38% of inpatients (IPs), irrespective of age. Across both insurance cohorts and age strata, more than 78% received two or more unique OP antibiotics, more than 34% received four or more unique OP antibiotics, more than 16% received repeat OP antibiotics, and more than 23% received one or more intravenous (IV) OP antibiotic. The mean 12-month cUTI-related total healthcare costs were $4,697 for OPs 65 years and older, $15,401 for IPs under age 65, and $17,431 for IPs 65 and older.
"In conclusion, the findings from this study indicate that many cUTIs do not resolve with the initial course of treatment and that a fair proportion of patients have recurrent infections," the study authors wrote. "The results also indicate that many patients receive prolonged durations of OP antibiotics despite data suggesting that shorter courses are as effective as longer durations of treatment."
They added that the findings highlight the need for new oral cUTI antibiotics and treatment approaches.
Jun 20 Open Forum Infect Dis abstract
Stewardship / Resistance Scan for Jun 21, 2022
Antimicrobial resistance and gender;
Burden, costs of complicated urinary tract infections
Filed Under:
Antimicrobial Stewardship
New project to explore connection between gender and antimicrobial resistance
Researchers in Africa and Asia have been selected to lead an upcoming research project that will explore the interconnections between antimicrobial resistance and gender.
The International Centre for Antimicrobial Resistance Solutions (ICARS) and the International Development Research Centre announced yesterday that the project will be led by South Africa's Human Sciences Research Council (HSRC), Jive Media Africa, and the Mahidol Oxford Tropical Medicine Research Unit (MORU) at Mahidol University in Thailand. The team will conduct systematic reviews, workshops, and interview with key experts to develop guidance for AMR research teams that are integrating gender into their work.
The ultimate aim of the guidance is to help strengthen the gender inclusiveness of AMR intervention and implementation research projects in low- and middle-income countries, particularly in sub-Saharan Africa and South Asia.
"We anticipate that this project will provide researchers with the necessary tools to capitalise on the potential of a gender lens to improve the quality, contextual relevance and impact of their AMR research," lead Investigators Ingrid Lynch of HSRC and Poy Naemiratch of MORU said in an ICARS news release.
The project is underway and will end in April 2023.
Jun 20 ICARS press release
Study finds frequent treatment failure for complicated urinary tract infections
An analysis of US health insurance data found frequent treatment failure in patients with complicated urinary tract infections (cUTIs), researchers reported yesterday in Open Forum Infectious Diseases.
Using data from two IBM MarketScan databases on privately insured and Medicare patients covering 2017 through 2019, researchers conducted a retrospective cohort study that looked at antibiotic treatment patterns, outcomes, and costs associated with cUTIs among adult patients, stratified by age (younger than 65 and 65 and over), over a 12-month follow-up period. Data from a recent US national database study indicates there are more than 2.8 million cUTI cases a year, but resistance to commonly used oral antibiotics is on the rise, and data on recurrent cUTIs is limited.
Among the 95,322 patients who met the study criteria, the initial setting of care was outpatient (OP) for 84%, and 87% were under 65 years of age. Treatment failure, which was defined as receipt a new unique OP antibiotic or a cUTI-related emergency department visit or hospital admission, occurred in 23% of OPs under 65 and 34% of those over 65, and over 38% of inpatients (IPs), irrespective of age. Across both insurance cohorts and age strata, more than 78% received two or more unique OP antibiotics, more than 34% received four or more unique OP antibiotics, more than 16% received repeat OP antibiotics, and more than 23% received one or more intravenous (IV) OP antibiotic. The mean 12-month cUTI-related total healthcare costs were $4,697 for OPs 65 years and older, $15,401 for IPs under age 65, and $17,431 for IPs 65 and older.
"In conclusion, the findings from this study indicate that many cUTIs do not resolve with the initial course of treatment and that a fair proportion of patients have recurrent infections," the study authors wrote. "The results also indicate that many patients receive prolonged durations of OP antibiotics despite data suggesting that shorter courses are as effective as longer durations of treatment."
They added that the findings highlight the need for new oral cUTI antibiotics and treatment approaches.
Jun 20 Open Forum Infect Dis abstract