Shiloh
Editor, Senior Moderator
Source: http://www.cidrap.umn.edu/news-perspective/2016/07/news-scan-jul-28-2016-0
News Scan for Jul 28, 2016
MCR-1 in Hong Kong; College mumps response
Filed Under:
Antimicrobial Stewardship; Mumps
[h=3]Hong Kong hospital screening finds MCR-1 in patient samples[/h] Screening of 1,427 bacterial isolates collected from patients in a large Hong Kong hospital during roughly 1-month period in December 2015 yielded 5 that were positive for MCR-1, a gene linked to resistance to colistin, a last-line antibiotic. A team from Hong Kong reported their findings yesterday in a letter yesterday to Emerging Infectious Diseases.
They focused their screening on Enterobacteriaceae and Acinetobacter species, with samples coming from blood, urine, stool, the respiratory system, wounds, and other sterile and nonsterile body fluids, tissues, or swabs.
Of the five that were positive for MCR-1, one was in Enterobacter cloacae and four were in Escherichia coli. Two were from blood cultures of patients with biliary tract infections, one was from a mid-stream sample from a patient with symptoms of a urinary tract infection, and two were from stool samples collected from asymptomatic patients.
Genetic testing showed a 100% match to MCR-1 previously identified in an E coli sample from a Chinese pig farm. One of the patients had lived in China before hospital admission, and one had undergone liver transplant in China. None had a history of colistin treatment.
All five samples with the MCR-1 gene were susceptible to carbapenem, but one of the E coli isolates from one of the patients showed extended-spectrum beta-lactamase (EBSL) activity.
The team noted that MCR-1 detection in the Enterobacteriaceae samples wasn't surprising because of previous findings in Chinese farm animals and retail meat. They noted, however, that finding the gene in E cloacae expands the species known to carry MCR-1.
Jul 27 Emerg Infect Dis report
[h=3]Study: Third dose of MMR vaccine may help in acute outbreaks[/h] Today the US Centers for Disease Control and Prevention (CDC) detailed the use of a third measles-mumps-rubella (MMR) vaccine dose during an acute outbreak of mumps at the University of Illinois Urbana-Champagne in their Morbidity and Mortality Weekly Report (MMWR). Though further tests for effectiveness need to be conducted, the CDC said the third booster dose may be a useful control measure during outbreaks.
On May 1, 2015, the Illinois Department of Public Health (IDPH) confirmed a mumps outbreak on the University of Illinois Urbana-Champaign?s campus, with a total of 317 cases reported over the course of 1 year. The vast majority of mumps cases were in students who had gotten the standard 2-dose vaccine (89%). The IDPH recommended a third dose of the MMR vaccine be distributed at campus health centers. A total of 11,500 doses of the MMR vaccine were administered beginning in August of 2015.
Of the 317 mumps cases, 50 patients (16%) had gotten 3 doses of MMR vaccine, 232 (73%) had received 2 doses, 12 (4%) received 1 dose, and 7 (2%) were unvaccinated. Sixteen people (5%) had unknown vaccination status. The CDC said though more studies are needed, using a third dose on college campuses, or anywhere people live in close quarters, during an outbreak could slow transmission.
Jul 29 MMWR report
News Scan for Jul 28, 2016
MCR-1 in Hong Kong; College mumps response
Filed Under:
Antimicrobial Stewardship; Mumps
[h=3]Hong Kong hospital screening finds MCR-1 in patient samples[/h] Screening of 1,427 bacterial isolates collected from patients in a large Hong Kong hospital during roughly 1-month period in December 2015 yielded 5 that were positive for MCR-1, a gene linked to resistance to colistin, a last-line antibiotic. A team from Hong Kong reported their findings yesterday in a letter yesterday to Emerging Infectious Diseases.
They focused their screening on Enterobacteriaceae and Acinetobacter species, with samples coming from blood, urine, stool, the respiratory system, wounds, and other sterile and nonsterile body fluids, tissues, or swabs.
Of the five that were positive for MCR-1, one was in Enterobacter cloacae and four were in Escherichia coli. Two were from blood cultures of patients with biliary tract infections, one was from a mid-stream sample from a patient with symptoms of a urinary tract infection, and two were from stool samples collected from asymptomatic patients.
Genetic testing showed a 100% match to MCR-1 previously identified in an E coli sample from a Chinese pig farm. One of the patients had lived in China before hospital admission, and one had undergone liver transplant in China. None had a history of colistin treatment.
All five samples with the MCR-1 gene were susceptible to carbapenem, but one of the E coli isolates from one of the patients showed extended-spectrum beta-lactamase (EBSL) activity.
The team noted that MCR-1 detection in the Enterobacteriaceae samples wasn't surprising because of previous findings in Chinese farm animals and retail meat. They noted, however, that finding the gene in E cloacae expands the species known to carry MCR-1.
Jul 27 Emerg Infect Dis report
[h=3]Study: Third dose of MMR vaccine may help in acute outbreaks[/h] Today the US Centers for Disease Control and Prevention (CDC) detailed the use of a third measles-mumps-rubella (MMR) vaccine dose during an acute outbreak of mumps at the University of Illinois Urbana-Champagne in their Morbidity and Mortality Weekly Report (MMWR). Though further tests for effectiveness need to be conducted, the CDC said the third booster dose may be a useful control measure during outbreaks.
On May 1, 2015, the Illinois Department of Public Health (IDPH) confirmed a mumps outbreak on the University of Illinois Urbana-Champaign?s campus, with a total of 317 cases reported over the course of 1 year. The vast majority of mumps cases were in students who had gotten the standard 2-dose vaccine (89%). The IDPH recommended a third dose of the MMR vaccine be distributed at campus health centers. A total of 11,500 doses of the MMR vaccine were administered beginning in August of 2015.
Of the 317 mumps cases, 50 patients (16%) had gotten 3 doses of MMR vaccine, 232 (73%) had received 2 doses, 12 (4%) received 1 dose, and 7 (2%) were unvaccinated. Sixteen people (5%) had unknown vaccination status. The CDC said though more studies are needed, using a third dose on college campuses, or anywhere people live in close quarters, during an outbreak could slow transmission.
Jul 29 MMWR report