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GARDP, Bugworks to collaborate on broad-spectrum antibiotic
News brief
13 minutes ago.
Chris Dall, MA
Topics
Antimicrobial Stewardship
The Global Antibiotic Research & Development Partnership (GARDP) today announced an agreement with Indian pharmaceutical company Bugworks Research Inc. to co-develop a new broad-spectrum antibiotic that targets some of the most difficult-to-treat bacterial pathogens
Under the agreement, GARDP will provide Bugworks up to $20 million in financial and technical support to develop BWC0977, a compound that has demonstrated in vitro activity against World Health Organization critical priority pathogens, including carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae. In return, GARDP will acquire the manufacturing and commercialization rights for BWC0977 in 146 primarily low- and middle-income countries (LMICs).
Addressing unmet public health needs
"We are excited to work with Bugworks to make key investments at this critical stage in the development of compound BWC0977," GARDP Executive Director Manica Balasegaram, MRCP, MSc, said in a press release. "Many compounds in the antibiotic pipeline lack innovative characteristics and fail to target priority pathogens. In contrast, BWC0977 stands out for its novelty and potential to address unmet public health needs."
The agreement makes official an alliance that was first announced in July 2023, when GARDP and Bugworks signed a non-binding term sheet to define the framework of a potential collaboration. GARDP says its support of BWC0977 depends on successful completion of key research and development milestones that align with its public health objectives.
Many compounds in the antibiotic pipeline lack innovative characteristics and fail to target priority pathogens. In contrast, BWC0977 stands out for its novelty and potential to address unmet public health needs.
Bugworks has received more than $12 million from CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) for pre-clinical development and a phase 1 study of BWC0977. The collaboration with GARDP aims to take the compound through approval and commercialization.
"An overarching goal of this partnership is to enable access to this compound simultaneously in Western countries and in LMICs with high AMR [antimicrobial resistance] burden," said Bugworks co-founder and CEO Anand Anandkumar, PhD. "We are grateful to CARB-X for their continued support for BWC0977 from lead optimization to human clinical trials, thus enabling the asset to enter the GARDP collaborative orbit."
Emergency department data show shift in antibiotics used for pediatric UTIs
News brief
19 minutes ago.
Chris Dall, MA
Topics
Antimicrobial Stewardship
An analysis of US emergency department (ED) visits for pediatric urinary tract infections (UTIs) provides some new insight into antibiotic prescribing practices, researchers reported today in Pediatrics.
Led by researchers from Boston Children's Hospital, the analysis aimed to evaluate changes in antibiotic prescribing at US ED visits for pediatric UTIs from 2011 to 2020 using nationally representative data from the National Hospital Ambulatory Medical Care Survey (NHAMCS). A previous analysis of NHAMCS data found that, from 1998 to 2007, there was a decline in use of trimethoprim-sulfamethoxazole (TMP-SMX) for pediatric UTIs amid rising resistance rates and a significant increase in the use of enteral third-generation cephalosporins (e3GC).
That finding raised concerns because e3GC are broad-spectrum antibiotics that can select for antibiotic resistance. In 2014, updated cephalosporin susceptibility criteria for Enterobacterales species made enteral first-generation cephalosporins (e1GC), which target fewer bacterial species, a potential empiric option for uncomplicated UTIs.
Increased use of first-generation cephaloporins
A total of 1,083 UTI visits by non-pregnant patients ages 18 and younger were included in the analysis. Over the study period, TMP-SMX prescriptions declined from 20.6% to 9.9% of visits, while use of e1GC increased from 15.2% to 32.6% of visits and use of e3CG remained unchanged. The findings persisted despite adjustments for age, sex, region, fever on presentation, payment type, and hospitalization.
"Although e3GC use had increased previously, their prescription rate did not significantly change, perhaps reflecting appropriate use in areas with higher resistance," the study authors wrote. "Given their association with development of resistance, ongoing monitoring and quality improvement will be important."
The authors add that the increased use of e1CG for pediatric UTIs is encouraging, because they're appropriate for empiric treatment but less likely to drive antibiotic resistance than other agents.
Having symptoms after getting a COVID vaccine may indicate robust immune response
News brief
Today at 11:50 a.m.
Mary Van Beusekom, MS
Topics
COVID-19
Headache, fatigue, malaise, and chills after COVID-19 vaccination are signs the immune system is marshalling a strong response against future infection, suggests a study posted today in the Annals of Internal Medicine.
University of California at San Francisco (UCSF) investigators analyzed serum neutralizing antibody (nAB) levels against the wild-type SARS-CoV-2 strain and daily symptom surveys in 363 unvaccinated, never-infected adults given two doses of an mRNA COVID-19 vaccine in 2021.
About 40% of the participants also wore a biometric device to measure their skin temperature and heart and breathing rate. Most participants were in their 40s to 60s.
Higher antibody levels after second dose
One and 6 months after receipt of the second vaccine dose, fatigue, malaise, chills, and headache were each tied to 1.4- to 1.6-fold higher nAB concentrations. nAB levels in participants who experienced at least seven symptoms were nearly double the levels of those who reported no symptoms.
In participants who wore a biometric device, each 1°C (1.8°F) increase in skin temperature after the second dose was associated with 1.8-fold and 3.1-fold higher nAB levels 1 and 6 months later.
"Generally, we found that the higher the number of side effects, the higher the level of antibodies," first author Ethan Dutcher, MD, PhD, said in a UCSF news release. "But this wasn't a hard rule: some people without side effects had better antibodies than some people with side effects."
The team noted that concerns about vaccine side effects often contribute to vaccine hesitancy. "The toll of COVID is still high for some—sickness, lost work, lasting fatigue and the dreaded long COVID," co–senior author Elissa Epel, PhD, said in the release. "While the symptoms from vaccination can be very unpleasant, it's important to remember that they don't come close to the disease's potential complications," she said.
While the symptoms from vaccination can be very unpleasant, it's important to remember that they don't come close to the disease's potential complications.
Elissa Epel, PhD
The Centers for Disease Control and Prevention recommends that everyone 6 months and older receive the updated COVID-19 vaccine and those 65 years and older receive an additional dose.
ALL BRIEFS
GARDP, Bugworks to collaborate on broad-spectrum antibiotic
News brief
13 minutes ago.
Chris Dall, MA
Topics
Antimicrobial Stewardship
The Global Antibiotic Research & Development Partnership (GARDP) today announced an agreement with Indian pharmaceutical company Bugworks Research Inc. to co-develop a new broad-spectrum antibiotic that targets some of the most difficult-to-treat bacterial pathogens
Under the agreement, GARDP will provide Bugworks up to $20 million in financial and technical support to develop BWC0977, a compound that has demonstrated in vitro activity against World Health Organization critical priority pathogens, including carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae. In return, GARDP will acquire the manufacturing and commercialization rights for BWC0977 in 146 primarily low- and middle-income countries (LMICs).
Addressing unmet public health needs
"We are excited to work with Bugworks to make key investments at this critical stage in the development of compound BWC0977," GARDP Executive Director Manica Balasegaram, MRCP, MSc, said in a press release. "Many compounds in the antibiotic pipeline lack innovative characteristics and fail to target priority pathogens. In contrast, BWC0977 stands out for its novelty and potential to address unmet public health needs."
The agreement makes official an alliance that was first announced in July 2023, when GARDP and Bugworks signed a non-binding term sheet to define the framework of a potential collaboration. GARDP says its support of BWC0977 depends on successful completion of key research and development milestones that align with its public health objectives.
Many compounds in the antibiotic pipeline lack innovative characteristics and fail to target priority pathogens. In contrast, BWC0977 stands out for its novelty and potential to address unmet public health needs.
Bugworks has received more than $12 million from CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) for pre-clinical development and a phase 1 study of BWC0977. The collaboration with GARDP aims to take the compound through approval and commercialization.
"An overarching goal of this partnership is to enable access to this compound simultaneously in Western countries and in LMICs with high AMR [antimicrobial resistance] burden," said Bugworks co-founder and CEO Anand Anandkumar, PhD. "We are grateful to CARB-X for their continued support for BWC0977 from lead optimization to human clinical trials, thus enabling the asset to enter the GARDP collaborative orbit."
Emergency department data show shift in antibiotics used for pediatric UTIs
News brief
19 minutes ago.
Chris Dall, MA
Topics
Antimicrobial Stewardship
An analysis of US emergency department (ED) visits for pediatric urinary tract infections (UTIs) provides some new insight into antibiotic prescribing practices, researchers reported today in Pediatrics.
Led by researchers from Boston Children's Hospital, the analysis aimed to evaluate changes in antibiotic prescribing at US ED visits for pediatric UTIs from 2011 to 2020 using nationally representative data from the National Hospital Ambulatory Medical Care Survey (NHAMCS). A previous analysis of NHAMCS data found that, from 1998 to 2007, there was a decline in use of trimethoprim-sulfamethoxazole (TMP-SMX) for pediatric UTIs amid rising resistance rates and a significant increase in the use of enteral third-generation cephalosporins (e3GC).
That finding raised concerns because e3GC are broad-spectrum antibiotics that can select for antibiotic resistance. In 2014, updated cephalosporin susceptibility criteria for Enterobacterales species made enteral first-generation cephalosporins (e1GC), which target fewer bacterial species, a potential empiric option for uncomplicated UTIs.
Increased use of first-generation cephaloporins
A total of 1,083 UTI visits by non-pregnant patients ages 18 and younger were included in the analysis. Over the study period, TMP-SMX prescriptions declined from 20.6% to 9.9% of visits, while use of e1GC increased from 15.2% to 32.6% of visits and use of e3CG remained unchanged. The findings persisted despite adjustments for age, sex, region, fever on presentation, payment type, and hospitalization.
"Although e3GC use had increased previously, their prescription rate did not significantly change, perhaps reflecting appropriate use in areas with higher resistance," the study authors wrote. "Given their association with development of resistance, ongoing monitoring and quality improvement will be important."
The authors add that the increased use of e1CG for pediatric UTIs is encouraging, because they're appropriate for empiric treatment but less likely to drive antibiotic resistance than other agents.
Having symptoms after getting a COVID vaccine may indicate robust immune response
News brief
Today at 11:50 a.m.
Mary Van Beusekom, MS
Topics
COVID-19
Headache, fatigue, malaise, and chills after COVID-19 vaccination are signs the immune system is marshalling a strong response against future infection, suggests a study posted today in the Annals of Internal Medicine.
University of California at San Francisco (UCSF) investigators analyzed serum neutralizing antibody (nAB) levels against the wild-type SARS-CoV-2 strain and daily symptom surveys in 363 unvaccinated, never-infected adults given two doses of an mRNA COVID-19 vaccine in 2021.
About 40% of the participants also wore a biometric device to measure their skin temperature and heart and breathing rate. Most participants were in their 40s to 60s.
Higher antibody levels after second dose
One and 6 months after receipt of the second vaccine dose, fatigue, malaise, chills, and headache were each tied to 1.4- to 1.6-fold higher nAB concentrations. nAB levels in participants who experienced at least seven symptoms were nearly double the levels of those who reported no symptoms.
In participants who wore a biometric device, each 1°C (1.8°F) increase in skin temperature after the second dose was associated with 1.8-fold and 3.1-fold higher nAB levels 1 and 6 months later.
"Generally, we found that the higher the number of side effects, the higher the level of antibodies," first author Ethan Dutcher, MD, PhD, said in a UCSF news release. "But this wasn't a hard rule: some people without side effects had better antibodies than some people with side effects."
The team noted that concerns about vaccine side effects often contribute to vaccine hesitancy. "The toll of COVID is still high for some—sickness, lost work, lasting fatigue and the dreaded long COVID," co–senior author Elissa Epel, PhD, said in the release. "While the symptoms from vaccination can be very unpleasant, it's important to remember that they don't come close to the disease's potential complications," she said.
While the symptoms from vaccination can be very unpleasant, it's important to remember that they don't come close to the disease's potential complications.
Elissa Epel, PhD
The Centers for Disease Control and Prevention recommends that everyone 6 months and older receive the updated COVID-19 vaccine and those 65 years and older receive an additional dose.
ALL BRIEFS