Shiloh
Editor, Senior Moderator
Source: http://www.cidrap.umn.edu/cidrap/content/influenza/general/news/feb0813fluscan.html
FLU NEWS SCAN: Novel flu C virus in pig, flu vaccine effects in elderly, H1N1 adjuvant scrutiny
Feb 8, 2013
Study: Oklahoma pig virus represents new influenza C subtype
An influenza virus that was recently identified in a sick pig in Oklahoma represents a new subtype of influenza C and suggests the possibility that type C viruses can evolve more rapidly than previously supposed, potentially posing an increased threat to humans, according to a report published yesterday in PLoS Pathogens. Flu C viruses, previously known to exist in only one subtype, occasionally cause illness in children, but cases are much less common than with A and B viruses. The researchers, from Minnesota, South Dakota, and Tennessee, isolated an orthomyxovirus from a sick pig and determined that it had seven RNA segments with about 50% overall identity to human flu C viruses. A phylogenetic analysis revealed that the degree of difference between this virus, dubbed C/OK, and human flu C viruses was similar to that between human flu A and B viruses. Antibody testing showed little cross-reactivity between C/OK and human flu C viruses. The new virus was able to infect both pigs and ferrets and spread to other animals by direct contact. The authors say their findings suggest that C/OK heralds a new flu C subtype. "This is significant, as co-circulation of multiple subtypes of influenza allows for rapid viral evolution through antigenic shift, a property previously only shown for influenza A viruses," they write. "The ability of C/OK to infect ferrets along with the absence of antibodies to C/OK in humans, suggests that such viruses may become a potential threat to human health."
Feb 7 PLoS Pathog report
Dec 7, 2012, report
Researchers suspect role of Pandemrix adjuvant in narcolepsy cases
The adjuvant in Pandemrix, GlaxoSmithKline's (GSK's) 2009 H1N1 vaccine, is among the ingredients under close scrutiny by researchers around the world for a possible role in the vaccine's link to cases of narcolepsy in kids in Finland, Sweden, and Ireland, Reuters reported today. The immune-boosting adjuvant, AS03, is also in a GSK H5N1 pandemic flu vaccine that a US Food and Drug Administration panel recommended in November for approval as a stockpiled vaccine, possibly paving the way for the first US approval of an adjuvanted flu vaccine. "The adjuvant in the Pandemrix vaccine is very potent and we think it may have played a role," said Markku Partinen, MD, PhD, a neurologist at the Helsinki Sleep Clinic who is investigating the vaccine-narcolepsy link. Outi Vaarala, MD, PhD, of the Immune Response Unit at Finland's National Institute for Health and Welfare says her group has found that the way antibodies from Pandemrix-vaccinated children bind to the virus antigen differs from what happens with a Canadian-made version. Others take a more cautious approach. Tomas Salmonson, MD, an official with the European Medicines Agency, which licenses Pandemrix, said, "We may speculate that this specific antigen together with a very potent adjuvant could be the cause for all this. But that's only one of several possible explanations."
Feb 8 Reuters story
Nov 15, 2012, CIDRAP News story on H5N1 vaccine
FLU NEWS SCAN: Novel flu C virus in pig, flu vaccine effects in elderly, H1N1 adjuvant scrutiny
Feb 8, 2013
Study: Oklahoma pig virus represents new influenza C subtype
An influenza virus that was recently identified in a sick pig in Oklahoma represents a new subtype of influenza C and suggests the possibility that type C viruses can evolve more rapidly than previously supposed, potentially posing an increased threat to humans, according to a report published yesterday in PLoS Pathogens. Flu C viruses, previously known to exist in only one subtype, occasionally cause illness in children, but cases are much less common than with A and B viruses. The researchers, from Minnesota, South Dakota, and Tennessee, isolated an orthomyxovirus from a sick pig and determined that it had seven RNA segments with about 50% overall identity to human flu C viruses. A phylogenetic analysis revealed that the degree of difference between this virus, dubbed C/OK, and human flu C viruses was similar to that between human flu A and B viruses. Antibody testing showed little cross-reactivity between C/OK and human flu C viruses. The new virus was able to infect both pigs and ferrets and spread to other animals by direct contact. The authors say their findings suggest that C/OK heralds a new flu C subtype. "This is significant, as co-circulation of multiple subtypes of influenza allows for rapid viral evolution through antigenic shift, a property previously only shown for influenza A viruses," they write. "The ability of C/OK to infect ferrets along with the absence of antibodies to C/OK in humans, suggests that such viruses may become a potential threat to human health."
Feb 7 PLoS Pathog report
Dec 7, 2012, report
Researchers suspect role of Pandemrix adjuvant in narcolepsy cases
The adjuvant in Pandemrix, GlaxoSmithKline's (GSK's) 2009 H1N1 vaccine, is among the ingredients under close scrutiny by researchers around the world for a possible role in the vaccine's link to cases of narcolepsy in kids in Finland, Sweden, and Ireland, Reuters reported today. The immune-boosting adjuvant, AS03, is also in a GSK H5N1 pandemic flu vaccine that a US Food and Drug Administration panel recommended in November for approval as a stockpiled vaccine, possibly paving the way for the first US approval of an adjuvanted flu vaccine. "The adjuvant in the Pandemrix vaccine is very potent and we think it may have played a role," said Markku Partinen, MD, PhD, a neurologist at the Helsinki Sleep Clinic who is investigating the vaccine-narcolepsy link. Outi Vaarala, MD, PhD, of the Immune Response Unit at Finland's National Institute for Health and Welfare says her group has found that the way antibodies from Pandemrix-vaccinated children bind to the virus antigen differs from what happens with a Canadian-made version. Others take a more cautious approach. Tomas Salmonson, MD, an official with the European Medicines Agency, which licenses Pandemrix, said, "We may speculate that this specific antigen together with a very potent adjuvant could be the cause for all this. But that's only one of several possible explanations."
Feb 8 Reuters story
Nov 15, 2012, CIDRAP News story on H5N1 vaccine