CID: Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus

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[h=1]Evidence for Human Adaptation and Foodborne Transmission of Livestock-Associated Methicillin-Resistant Staphylococcus aureus[/h]

• Jesper Larsen1,
• Marc Stegger1,5,
• Paal S. Andersen1,2,
• Andreas Petersen1,
• Anders R. Larsen1,
• Henrik Westh2,3,
• Yvonne Agers?4,
• Alexandra Fetsch7,
• Britta Kraushaar7,
• Annemarie K?sbohrer7,
• Andrea T. Feβler8,
• Stefan Schwarz8,
• Christiane Cuny9,
• Wolfgang Witte9,
• Patrick Butaye10,12,
• Olivier Denis11,
• Marisa Haenni13,
• Jean-Yves Madec13,
• Eric Jouy16,
• Frederic Laurent14,15,
• Antonio Battisti17,
• Alessia Franco17,
• Patricia Alba17,
• Caterina Mammina19,
• Annalisa Pantosti18,
• Monica Monaco18,
• Jaap A. Wagenaar20,22,
• Enne de Boer21,
• Engeline van Duijkeren23,
• Max Heck23,
• Lucas Dom?nguez24,
• Carmen Torres25,
• Myriam Zarazaga25,
• Lance B. Price5,6,a, and
• Robert L. Skov1,a

+ Author Affiliations

• [SUP]1[/SUP]Statens Serum Institut, Copenhagen
• [SUP]2[/SUP]University of Copenhagen, Frederiksberg
• [SUP]3[/SUP]Hvidovre Hospital
• [SUP]4[/SUP]Technical University of Denmark, Lyngby
• [SUP]5[/SUP]Translational Genomics Research Institute, Flagstaff, Arizona
• [SUP]6[/SUP]George Washington University, Washington D.C.
• [SUP]7[/SUP]Federal Institute for Risk Assessment, Berlin
• [SUP]8[/SUP]Friedrich-Loeffler-Institut, Neustadt-Mariensee
• [SUP]9[/SUP]Robert Koch Institut, Wernigerode, Germany
• [SUP]10[/SUP]Ghent University
• [SUP]11[/SUP]Universit? Libre de Bruxelles, Brussels, Belgium
• [SUP]12[/SUP]Ross University School of Veterinary Medicine, Basseterre, Saint Kitts and Nevis
• [SUP]13[/SUP]French Agency for Food, Environmental and Occupational Health and Safety, Lyon
• [SUP]14[/SUP]Universit? Claude Bernard Lyon 1
• [SUP]15[/SUP]Hospices Civils de Lyon
• [SUP]16[/SUP]French Agency for Food, Environmental and Occupational Health and Safety, Ploufragan, France
• [SUP]17[/SUP]Istituto Zooprofilattico Sperimentale delle Regioni Lazio e Toscana
• [SUP]18[/SUP]Istituto Superiore di Sanit?, Rome
• [SUP]19[/SUP]University of Palermo, Italy
• [SUP]20[/SUP]Utrecht University
• [SUP]21[/SUP]Netherlands Food and Consumer Product Safety Authority, Utrecht
• [SUP]22[/SUP]Central Veterinary Institute, Lelystad
• [SUP]23[/SUP]National Institute for Public Health and the Environment, Bilthoven, The Netherlands
• [SUP]24[/SUP]Complutense University of Madrid
• [SUP]25[/SUP]University of La Rioja, Logro?o, Spain

• Correspondence: J. Larsen, Microbiology and Infection Control, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark (jrl@ssi.dk).

• ↵a L. B. P. and R. L. S. are joint senior authors.

[h=2]Abstract[/h] We investigated the evolution and epidemiology of a novel livestock-associated methicillin-resistant Staphylococcus aureus strain, which colonizes and infects urban-dwelling Danes even without a Danish animal reservoir. Genetic evidence suggests both poultry and human adaptation, with poultry meat implicated as a probable source.

http://cid.oxfordjournals.org/content/early/2016/09/01/cid.ciw532.abstract