tetano
Editor, Senior Moderator
J Org Chem. 2013 Oct 21. [Epub ahead of print]
Chiral Iminoesters Derived from D-Glyceraldehyde in [3+2] Cycloaddition Reactions. Asymmetric Synthesis of a Key Intermediate in the Synthesis of Neuramidinase Inhibitors.
Galvez JA, Diaz-De-Villegas MD, Al?as M, Badorrey R.
Abstract
Silver-catalyzed endo-selective and copper-catalyzed exo-selective asymmetric [3+2] cycloadditions of acrylates to chiral iminoesters derived from D-glyceraldehyde have been investigated. The reaction diastereoselectively provides highly functionalized pyrrolidines. This approach was used to develop the first asymmetric synthesis of a key intermediate in the synthesis of pyrrolidine influenza neuramidinase inhibitors.
PMID:
24143968
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24143968
Chiral Iminoesters Derived from D-Glyceraldehyde in [3+2] Cycloaddition Reactions. Asymmetric Synthesis of a Key Intermediate in the Synthesis of Neuramidinase Inhibitors.
Galvez JA, Diaz-De-Villegas MD, Al?as M, Badorrey R.
Abstract
Silver-catalyzed endo-selective and copper-catalyzed exo-selective asymmetric [3+2] cycloadditions of acrylates to chiral iminoesters derived from D-glyceraldehyde have been investigated. The reaction diastereoselectively provides highly functionalized pyrrolidines. This approach was used to develop the first asymmetric synthesis of a key intermediate in the synthesis of pyrrolidine influenza neuramidinase inhibitors.
PMID:
24143968
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24143968