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China's vaccination not to blame for bird flu virus mutation

AlaskaDenise

In Memoriam
http://english.people.com.cn/200612/10/eng20061210_330812.html

An international panel of experts has rejected the notion that China's vaccination program has caused the bird flu virus to mutate.

The experts from the World Health Organization, the UN's Food and Agriculture Organization and the World Organization for Animal Health, told Xinhua the "Fujian-like virus" is actually not a new strain and was identified in 2005.

It relates to the bird flu virus extracted from poultry samples in 2004, according to the panel.

The mutation of influenza virus is a natural process. There is no scientific evidence backing the theory that H5N1 bird flu virus has evolved as a result of China's vaccination program, it said.

A scientific paper released by the U.S. Proceedings of the National Academy of Sciences identified a strain of bird flu virus found in southern China, Malaysia and Laos, calling it a "Fujian-like virus", adding that it was vaccine resistant.

WHO officials have previously criticized the naming process of different strains saying it stigmatized particular countries and regions.

David Heymann, interim WHO director who participated in the panel which held discussions from Dec. 4 to 8, expressed appreciation of China's cooperative efforts in fighting the disease.

"A Chinese virus has been used in this network (the WHO collaborating network) to develop what is called the prototype vaccine for pandemic influenza," he said. "So China has contributed significantly and internationally."

The panel suggested China and other countries further monitor the virus mutation and vaccination on small-scale farms.
Source: Xinhua


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Re: China's vaccination not to blame for bird flu virus mutation

I smell politics.

China was not happy at what it saw as blame for the creation/spread of what the PNAS paper called 'Fujian' H5N1 and this seems like an attempt to spread oil on troubled waters. While there may not be any 'scientific evidence' that the vaccination program 'created' this strain and its ancestory clearly predates the vax program basic Darwian natural selection would dictate that the viral landscape would be effected by mass vaccination.
Consider the text book case of moths in England, (for those of you that did not have to learn about these in school see below). Here we have a range of H5N1 strains and the vaccination of one of their main host species (domestic poultry) against one of the most common strains. The inevitable consequence of this is the inability of this strain to reproduce in this host and in the event of infection by a resistant - or partially resistant - strain the flock may then spread the infection. Over time this will shift the relative density of the two strains towards resistant forms. Ergo the distributions of strains today will not be the same as it would have been had there been no vaccination program, any attempt to argue the contary would require a significant rewriting of most evolutionary theory.

If you disagree please post your counter arguments.

The moths had a natural variation in thier colouring and were predated by birds, in industrial areas the slightly darker ones were better camafaged against grimy tree trunks and the lighter ones faired better in pristine areas, over time this lead to genetically distinct popultations.
 
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Re: China's vaccination not to blame for bird flu virus mutation

Right on JJ. You nailed the situation and the result on the head.
 
Re: China's vaccination not to blame for bird flu virus mutation

H5N1 evolution is a very political issue and related comments are frequently.

A little pressure (like widespread vaccinations) allows H5N1 to show off what it does best, which is evolve.
 
Re: China's vaccination not to blame for bird flu virus mutation

but does H5N1 go back from vaccinated birds back to wild birds ?
Has this been examined ?
We know about the evolution in wild birds but chickens had
usually been a dead end AFAIK.
 
Re: China's vaccination not to blame for bird flu virus mutation

gsgs said:
but does H5N1 go back from vaccinated birds back to wild birds ?
Has this been examined ?
We know about the evolution in wild birds but chickens had
usually been a dead end AFAIK.
Wild birds are the key and have been moving sequences around forever. That is how H5N1 evolves.
 
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