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China: New form of blue-ear virus causing pig deaths

Gert van der Hoek

In Memoriam - Editor, Senior Moderator
China: New form of blue-ear virus causing pig deaths - Summary


Beijing - A deadly disease spreading among pigs in China is caused by a new variant of the blue-ear virus, China's top veterinary official said Monday. Jia Youling, director of the veterinary office in China's Agriculture Ministry, said the current form of the virus is more deadly and contagious than the blue-ear virus initially discovered in China in the 1990s.

That original virus had affected only sows and piglets, but the virus is now striking boars, he said.

The blue-ear virus has swept through 26 of China's 33 provinces and regions, but veterinary officials and farmers are fighting back with immunizations and culls, Jia said in Beijing.

The disease has caused numerous pig deaths and has driven up pork prices in the world's largest pork producer, but Jia said a test for the virus and a vaccine had already been developed and production was being conducted at 12 factories.

More than 100 million of China's 500 million pigs - half the world's population - have been immunized so far, Jia said, adding that the central and local governments were bearing the cost of the vaccinations.

Those governments have reported 257,000 cases of blue-ear disease this year, of which 68,000 pigs have died. Another 175,000 have been culled. But unconfirmed reports said millions of pigs have died.

Blue-ear disease, also known as porcine reproductive and respiratory syndrome, usually produces elevated temperatures, lethargy and reduced appetite in breeding sows. Bruising may also occur, sometimes giving their ears a blue appearance. The disease is also often deadly in piglets and raises the incidence of premature births, stillbirths and weak piglets.

The new variant of the virus also attacks the immune system, Jia said, making infected animals susceptible to secondary infections.

Jia insisted that China has brought the virus under control and rejected concerns that the government is not divulging the full extent of the outbreak, given its belated disclosures of the outbreak of SARS, or severe acute respiratory syndrome, in 2002.

He said his ministry is keeping the UN's Food and Agriculture Organization and the World Organization for Animal Health informed of the latest developments and, while China has not called for an investigation into the virus by international bodies, it was prepared to cooperate with such agencies and hold talks on the disease.

Jia insisted, however, that China was capable of handling the disease outbreak on its own.

China's top veterinarian said samples of the blue-ear vaccine have been sent to Vietnam, seven of whose 64 provinces have also been hit by the disease.

Although the disease is not transmissible to humans, according to Jia and the UN's Food and Agriculture Organization, the people of China have been affected by skyrocketing prices for a staple of the Chinese diet.

The cost of pork has risen 75 per cent in June from the same month a year earlier, thanks in part to blue-ear disease, but also because many farmers have stopped raising pigs because of rising feed prices.

http://www.earthtimes.org/articles/show/95691.html
 
Re: China: New form of blue-ear virus causing pig deaths

> More than 100 million of China's 500 million pigs - half the
> world's population - have been immunized so far, Jia said

let me assume a pig costs $100 and vaccinating a pig costs $5
(is it realistic?) , so you would reasonably vaccinate when you
expect a 5% probability that the pig gets lost by disease.

Vaccinating 100M pigs costs $500M , the same as 5 million pigs.
So I estimate that an 5million pigs are lost due to blue ear disease
during one vaccination season.
 
Re: China: New form of blue-ear virus causing pig deaths

<TABLE cellSpacing=0 cellPadding=0 width="100%"><TBODY><TR><TD class=content01>Blue-ear Pig Disease under "Preliminary Control"</TD></TR><TR><TD height=45><TABLE cellSpacing=1 cellPadding=5 width="100%" bgColor=#cccccc><TBODY><TR><TD class=content02 bgColor=#e8e8e8> 2007-08-20 20:35:23 Xinhua</TD></TR></TBODY></TABLE></TD></TR><TR><TD><TABLE class=content03 id=dstTable cellSpacing=0 cellPadding=0 width="100%"><TBODY><TR><TD>Blue-ear pig disease has been brought under "preliminary control" through vaccinations and mass culls of infected pigs, <?xml:namespace prefix = st1 ns = "urn:schemas-microsoft-com:office:smarttags" /><st1:place w:st="on"><st1:City w:st="on">Jia Youling</st1:City>, <st1:country-region w:st="on">China</st1:country-region></st1:place>'s chief veterinary officer, said on Monday. :rolleyes: <?xml:namespace prefix = o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p>
<o:p></o:p>
According to the Ministry of Agriculture (MOA), as of August 19, the disease had infected 257,000 pigs in 26 Chinese provinces, of which 68,000 died and 175,000 were destroyed. <o:p></o:p>
<o:p></o:p>
The highly pathogenic disease, also known as Porcine Reproductive and Respiratory Syndrome, can be fatal for pigs, but the vaccinated pigs will no longer be infected by the disease, according to Jia. <o:p></o:p>
<o:p></o:p>
He said 12 enterprises had been assigned to produce an effective vaccine against the disease with a daily production capacity of seven to ten million milliliters. <o:p></o:p>
<o:p></o:p>
"<st1:country-region w:st="on"><st1:place w:st="on">China</st1:place></st1:country-region> has so far administered 2.96 million milliliters of vaccines to protect more than 100 million pigs from the disease and no blue-ear diseases have been found in places that have completed the vaccination process," said Jia. <o:p></o:p>
<o:p></o:p>
"People are no longer scared of the disease because they know what the disease is and how to deal with it," Jia claimed. <o:p></o:p>
<o:p></o:p>
In response to criticisms that China had downplayed the outbreak of the disease, Jia said the Chinese government had been "open and transparent" about the disease and has provided regular updates to the United Nations Food and Agriculture Organization (FAO) and the World Organization for Animal Health (OIE). <o:p></o:p>
<o:p></o:p>
"This has prevented unnecessary suspicion and misunderstandings and helped the international community understand the situation," said Jia. <o:p></o:p>
<o:p></o:p>
Jia did admit that local authorities might have covered up the number of infected pigs. However, the number of diseased pigs was nowhere near as big as reported in some foreign media, he stressed. <o:p></o:p>
<o:p></o:p>
The New York Times reported last week that China failed to send tissue samples of affected pigs to labs outside the country and the lack of transparency about the disease was creating fears of a global pandemic. <o:p></o:p>
<o:p></o:p>
Jia said the ministry had provided vaccine samples to <st1:country-region w:st="on">Vietnam</st1:country-region> as requested but no international organization had asked <st1:country-region w:st="on"><st1:place w:st="on">China</st1:place></st1:country-region> to provide tissue samples. :confused: <o:p></o:p>
<o:p></o:p>
He said his ministry would be happy to cooperate with other countries to fight the disease. <o:p></o:p>
<o:p></o:p>
Guo Fusheng, a technical advisor with the FAO, confirmed that the organization had not yet asked <st1:country-region w:st="on"><st1:place w:st="on">China</st1:place></st1:country-region> for tissue samples.:tiphat: http://english.cri.cn/2946/2007/08/20/168@263910.htm
</TD></TR></TBODY></TABLE></TD></TR></TBODY></TABLE>
 
Re: China: New form of blue-ear virus causing pig deaths

> but no international organization had asked China to provide tissue samples

they should establish some automatical asking process.
Can't be so difficult. The spammers could tell them how to do it...
 
China Says Pig Virus Outbreak Under Control, But Questions Remain

China Says Pig Virus Outbreak Under Control, But Questions Remain

<table style="direction: ltr;" border="0" width="100%"><tbody><tr><td>China Says Pig Virus Outbreak Under Control, But Questions Remain</td></tr> <tr> <td valign="top"> By Heda Bayron
Hong Kong
21 August 2007
</td> <td align="left" valign="top">
</td> </tr> </tbody></table>
China's chief veterinarian says a pig virus outbreak that has killed tens of thousands of pigs is under control. But as VOA's Heda Bayron reports from Hong Kong, doubts remain over the extent and nature of the outbreak as China has yet to share samples with international laboratories.

China has been criticized for not sharing samples of a virus that it says infected 175,000 pigs and killed tens of thousands of those, across most of the country.

<table class="APIMAGE" style="direction: ltr;" align="left" width="210"> <tbody> <tr> <td>
AP_China_pig_21aug07_210.jpg
</td></tr> <tr> <td class="imagecaption">Worker prepares vaccine to inject into pigs in village located in Shandong province, 07 Aug 2007</td></tr></tbody></table>China says the disease is now under control after pigs were vaccinated. But without samples, international experts wonder whether the virus is really what China says it is. China identifies it as blue ear disease or porcine reproductive and respiratory syndrome or PRRS, which is read by scientists as "Pers".

Some experts are alarmed at the large number of pig deaths in China, saying it is unusually high.

Juan Lubroth, senior officer of infectious diseases at the Food and Agriculture Organization says Chinese scientists told the U.N. agency the virus has changed.

"What they have alerted us to is that this particular virus seems to be hotter or more virulent than what was previously described in North America, Europe or elsewhere," he said. "So there has been some changes in the virus that perhaps make it a bit more lethal. This needs to be studied further and we have to see whether it's acting alone or acting in synergy with some other pathogens."

This is why, Lubroth says, an independent confirmation from a laboratory specializing on the PRRS virus is needed.

Jia Youling, China's chief vet, said Monday no such request has been made.
Jia says he does not know where to send the samples because he does not know who needs them.

He added that China does not need international help in detection because Chinese experts fully understand the structure of the virus.

PRRS causes high fever, diarrhea and rashes in pigs, turning their ears blue, but is not infectious to humans.

Chinese scientists say that in the past, fatal cases from PRRS mostly involved young pigs. But now it is infecting many adult pigs, the disease duration is shorter and it is more contagious. They conclude that environmental factors such as temperature and high humidity, and secondary bacterial infections, may be sparking mutation.

The Chinese government has been sharply criticized in the past for not promptly sharing information about infectious disease outbreaks.

When the highly infectious Severe Acute Respiratory Syndrome or SARS appeared in 2003, it jumped from animals to humans. It spread quickly and killed many people all over the world before China admitted being the source of the outbreak.

The PRRS outbreak this year has caused economic losses to China's pig farmers and the pig deaths are believed to be helping drive pork prices up.

Veterinary experts are also investigating a blue ear outbreak in Vietnam, raising concerns that the virus may have spread beyond China's borders.

Neighboring Cambodia has banned imports of live pigs because of the outbreaks.



http://www.voanews.com/english/2007-08-21-voa7.cfm?rss=health
 
Pigs in China

Pigs in China

[FONT=verdana, geneva, arial, sans serif][SIZE=-1] Pigs in China[/SIZE][/FONT]

[FONT=verdana, geneva, arial, sans serif][SIZE=+1]Death on the farm
[/SIZE][/FONT] [FONT=verdana,geneva,arial,sans serif][SIZE=-2]Aug 23rd 2007 | BEIJING
From The Economist print edition
[/SIZE][/FONT]

[FONT=verdana,geneva,arial,sans serif][SIZE=-1]Making a pig's ear of disease control

[/SIZE][/FONT] <!--back-->[FONT=verdana,geneva,arial,sans serif][SIZE=-1] WITH pigs dying all over the country and the price of pork soaring, China has come under suspicion of attempting to cover up a dangerous outbreak of an infectious disease. It is not the first time such suspicions have fallen upon China, and though the government's performance in this case has shown some modest improvement, it is not likely to be the last.[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1]
[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1] As a health threat, the current outbreak of Porcine Reproductive and Respiratory Syndrome ([SIZE=-1]PRRS[/SIZE]), also known as ?blue-ear pig disease?, is nothing like the earlier cases, where human lives were at risk. Avian influenza has appeared in pockets in China in recent years and has occasionally spread to?and even killed?humans, but [SIZE=-1]PRRS[/SIZE] can affect only pigs. It is even less like Severe Acute Respiratory Syndrome ([SIZE=-1]SARS[/SIZE]), a highly contagious human disease, which in 2003 killed hundreds worldwide as panic and quarantine measures brought China close to a standstill.[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1]
[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1] But in its handling of the[SIZE=-1] PRRS [/SIZE]outbreak, China has inspired some unfortunate comparisons with those earlier cases, when it was caught wrongly denying there was any problem, and then stonewalling requests for information from abroad. This time, international health officials have for months been wondering what to make of anecdotal reports of massive numbers of infected pigs. The price of live pigs has rocketed, up by 85% in July on the same month in 2006. Foreign agricultural officials based in Beijing accuse the government of a lack of transparency. ?Information about this,? grumbles one, ?has been flowing like cold molasses on a winter's day.?[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1]
[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1] Even so, China has been much prompter this time in seeking to allay concerns caused by the disease. Its chief veterinary officer, Jia Youling, called a press conference on August 20th to report that [SIZE=-1]PRRS[/SIZE] had been brought under ?preliminary control?. The disease had infected 257,000 pigs in 26 provinces, of which 68,000 died and 175,000 were destroyed. But through a massive vaccination programme 100m pigs were already protected. ?People are no longer scared of the disease because they know what the disease is and how to deal with it,? he said. This glides rather airily over the government's previous failure to acknowledge that people had ever been scared. He also admitted that some local officials had indeed covered up the disease in their jurisdictions.[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1]
[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1] According to Guo Fusheng, a technical adviser to the United Nations Food and Agriculture Organisation ([SIZE=-1]FAO[/SIZE]), China's response has been somewhat better than during the 2003 [SIZE=-1]SARS[/SIZE] outbreak. But it would be helpful, he said, if China shared tissue samples with international organisations. He felt optimistic that its officials soon would. Infected pigs have also been found in one other country, China's neighbour, Vietnam. The [SIZE=-1]FAO[/SIZE] and other foreign authorities also want more information about this vaccine that China claims to be using so successfully. Vaccines have hitherto not been known to be effective against the disease, which tends to mutate quickly. ?It would be something of a breakthrough,? says Dr Guo, ?so of course we would like to know more about it.?[/SIZE][/FONT]


[FONT=verdana,geneva,arial,sans serif][SIZE=-1]http://www.economist.com/world/asia/displaystory.cfm?story_id=9687970[/SIZE][/FONT]
[FONT=verdana,geneva,arial,sans serif][SIZE=-1]
[/SIZE][/FONT]
 
Re: China: New form of blue-ear virus causing pig deaths

<TABLE class=lan18 cellSpacing=0 cellPadding=0 width="97%" align=center border=0><TBODY><TR><TD class=hei22 vAlign=bottom height=25>China reports drastic decline in blue-ear pig disease
typk.jpg
:magnify:
</TD></TR><TR><TD bgColor=#ffffff height=4></TD></TR></TBODY></TABLE><TABLE cellSpacing=0 cellPadding=0 width="50%" align=center border=0><TBODY><TR><TD height=8></TD></TR></TBODY></TABLE><TABLE cellSpacing=0 cellPadding=0 width="97%" align=center border=0><TBODY><TR><TD width="48%">www.chinaview.cn
space.gif
2007-08-23 15:55:38
</TD><TD class=hui12 align=middle width="26%"> </TD><TD class=hui12 align=middle width="12%">
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</TD></TR></TBODY></TABLE><TABLE cellSpacing=0 cellPadding=0 width="80%" border=0><TBODY><TR><TD height=20></TD></TR></TBODY></TABLE><TABLE class=lt14 cellSpacing=0 cellPadding=0 width="97%" align=center border=0><TBODY><TR><TD class=lt14>


BEIJING, Aug. 23 (Xinhua) -- China's Ministry of Agriculture (MOA) said on Thursday 47,000 pigs were infected by blue-ear pig disease in July, down 51.5 percent from the previous month.

Of the infected pigs, 13,000 died, down 35.9 percent, said spokesman for the ministry Xue Liang.
"The epidemic across the country has been under much control,":rolleyes: Xue said at a press conference. <TABLE style="WIDTH: 176px; HEIGHT: 11px" height=11 cellSpacing=0 cellPadding=0 width=176 align=center border=0><TBODY><TR><TD style="FONT-SIZE: 12px">
xin_4420804232105093268367.jpg
</TD></TR><TR><TD style="FONT-SIZE: 12px">
Xue Liang (L), spokesman for China's Ministry of Agriculture, gestures during a news conference in Beijing Aug. 23, 2007. China's Ministry of Agriculture said on Thursday 47,000 pigs were infected with blue-ear pig disease in July, down 51.5 percent from the previous month. The epidemic across the country has been under much control. (Xinhua/Yuan Man)
Photo Gallery>>>
</TD></TR></TBODY></TABLE>

Xue said by Aug. 22, China had administered 314 million milliliters of vaccine to immunize more than 100 million pigs. By then, the disease had infected 257,000 pigs in 26 Chinese provinces, of which 68,000 died and 175,000 were destroyed.
The epidemic situation in regions along the Yangtze River is relatively more serious because the disease is inducible under wet and warm conditions, said the spokesman.
The ministry had sent 251 experts to the disease-stricken areas and printed more than 600,000 handbooks to publicize knowledge on the prevention and control of the disease, he said.
The highly pathogenic disease, also known as Porcine Reproductive and Respiratory Syndrome, can be fatal for pigs, but the vaccinated pigs will no longer be infected by the disease, according to the ministry.
Twelve enterprises had been assigned to produce an effective vaccine against the disease with a daily production capacity of seven to ten million milliliters, said the spokesman.
The average wholesale price of pork from Aug. 13 to 19 saw a week-on-week drop of 1.4 percent, according to the Ministry of Commerce.
It was the second consecutive weekly drop in pork prices, which have almost doubled in the last seven months due to short supply and mounting production costs.
Li Jinxiang, a veterinarian with the ministry, said China had timely reported the epidemic situation to the international community in line with regulations of the world organization for animal health (OIE).
The MOA had organized regular joint meetings with the Ministry of Health, the UN Food and Agriculture Organization (FAO) and the World Health Organization (WHO) to discuss relevant policies and exchange disease-control technologies, according to Li. Jia Youling, China's chief veterinary officer, said on Monday that the ministry had provided vaccine samples to Vietnam as requested but no international organization had asked China to provide tissue samples. Guo Fusheng, a technical advisor with the FAO, has confirmed that the organization had not yet asked China for tissue samples. <TABLE style="WIDTH: 176px; HEIGHT: 11px" height=11 cellSpacing=0 cellPadding=0 width=176 align=center border=0><TBODY><TR><TD style="FONT-SIZE: 12px">
xin_4420804232105375234608.jpg
</TD></TR><TR><TD style="FONT-SIZE: 12px">
Li Jinxiang (R), an inspector with the Veterinary Bureau under China's Ministry of Agriculture, speaks during a news conference in Beijing Aug. 23, 2007. (Xinhua/Yuan Man)
Photo Gallery>>>
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http://news.xinhuanet.com/english/2007-08/23/content_6590868.htm
 
Re: China: New form of blue-ear virus causing pig deaths

PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME - CHINA, VIET NAM

[1] China, Viet Nam
[2] Viet Nam

******
[1] China, Viet Nam
Date: Fri, 24 Aug 2007
Source: Science, News of the Week, Vol. 317, no. 5841, p. 1017 [edited]
<http://www.sciencemag.org/cgi/content/full/317/5841/1017>


China, Viet Nam grapple with 'rapidly evolving' pig virus

A pig disease ravaging China now appears to have spilled into Viet
Nam. Scientists fear that a deadlier strain of a longtime foe,
porcine reproductive and respiratory syndrome (PRRS), or blue ear
disease, may be on the loose.

"We're fairly confident that there has been an outbreak of PRRS
here," says Andrew Speedy, who represents the UN Food and Agriculture
Organization (FAO) in Viet Nam. An FAO mission that completed a
weeklong visit to Viet Nam on 20 Aug 2007 also uncovered many
secondary infections that increase the disease's death toll, Speedy
says. The team concluded that PRRS can likely be controlled through
vaccination and antibiotic treatment of secondary infections.

PRRS was 1st identified in the United States in the mid-1980s; the
causative arterivirus was isolated in 1991. The virus does not infect
humans. In pigs, it attacks macrophages, which ingest and remove
invading bacteria. With a crippled immune response, pigs are
susceptible to secondary infections. Adults usually recover and
develop immunity, but the virus and secondary infections can kill
piglets, whose ears often turn blue from the secondary infections.

"The evolution of the virus is really quite startling. It is probably
one of the most rapidly evolving viruses that I know of," says Trevor
Drew, head of virology at the Veterinary Laboratories Agency in
Weybridge, UK. He explains that, typically, a virus circulating in a
new host initially causes severe disease and becomes less pathogenic
over time. With PRRS there is evidence that the opposite has
occurred: a nonpathogenic strain was circulating among pigs in North
America before it evolved and started causing disease.


An even nastier strain seems to be on the rampage in China, killing
sows as well as piglets. This strain 1st appeared in the summer of
2006. China has reported losing 400 000 pigs to the disease through
death or culling in 2006 and another 243 000 this year [2007],
although some contend that official numbers vastly understate the losses.

In an analysis of viral samples from pigs in China published online
in PLoS ONE [Public Library of Science] on 13 Jun 2007, a group led
by George Gao, a microbiologist who heads the Institute of
Microbiology in Beijing, described a genetic variation that may be
responsible for the virus's increased deadliness. Drew, who finds
that claim plausible, says that the possibility of a new and deadlier
strain "is very worrisome."

Media outlets, including an article last week in The New York Times
[16 Aug 2007], reported allegations that China has refused to share
virus samples and cooperate with international organizations. Drew
says that's not so, pointing to Gao's paper and to China's reporting
on the outbreak to the Paris-based World Organization for Animal
Health [OIE]. Guo Fusheng of FAO's Beijing office says that the
organization has not yet asked China's Ministry of Agriculture for
samples or to allow an outside team to investigate, although it
expects to make a formal request shortly.


Viet Nam didn't wait to be asked. The disease was 1st reported there
in March [2007]. Last month [July 2007], the government asked FAO for
assistance after the outbreaks increased in June and July [2007].
Samples have been sent to US labs for analysis
[see commentary].

[Byline: Dennis Normile]

--
Communicated by:
Doug Powell
International Food Safety Network - AnimalNet
Kansas State University
USA
<dpowell@KSU.EDU>

******
[2] Viet Nam
Date: Wed 22 Aug 2007
Source: ChinaView, Xinhua News Agency report [edited]
<http://news.xinhuanet.com/english/2007-08/22/content_6581730.htm>


Porcine Reproductive and Respiratory Syndrome (PRRS), commonly known
as blue ear disease, has recently stricken a number of pigs in Viet
Nam's southern Ba Ria Vung Tau province and central Binh Dinh
province, according to local newspaper People's Army report Wednesday
[22 Aug 2007].

Specimens from 40 pigs in Dat Do district in Ba Ria Vung Tau and some
of the animals in the 2 districts of Phu Cat and Tuy Phuoc in Binh
Dinh have tested positive to PRRS, the paper quoted Bui Quang Anh,
head of the Department of Animal Health under the Vietnamese Ministry
of Agriculture and Rural Development.

Local veterinary agencies are intensifying the culling of infected
pigs to prevent the disease from spreading.

Now, the disease is hitting 4 Vietnamese provinces, namely Quang Nam,
Quang Ngai, and Binh Dinh in the central area, and Ba Ria Vung Tau
[in the southern area; see map of areas and provinces at
<http://www.angelfire.com/co/hongnam/vnmap.html>. - Mod.AS]

PRRS is characterized by reproductive failure of sows and respiratory
problems of piglets and growing pigs. It occurs in most major
pig-producing areas throughout the world.

According to the World Organization for Animal Health, the
reproductive failure is characterized by infertility, late fetal
mummification, abortions, stillbirths, and the birth of weak piglets
that often die soon after birth from respiratory disease and
secondary infections.

--
Communicated by:
ProMED-mail Rapporteur Dan Silver

[The support of FAO and the involvement of US laboratories in the
investigations regarding the Vietnamese pathogens are encouraging
news. Results are anticipated with interest, and expected to include
comparative studies with PRRS virus strains from other sources,
particularly China. To this end, provision of samples from China and
the cooperation of the Chinese scientists are essential.
- Mod.AS]:tiphat:

http://tinyurl.com/yqfsuz
 
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