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China: Man Dies; Infected Father "Improving"; More Suspects

Re: China: Man Dies; Infected Father "Improving"; More Suspects

Even CIDRAP is picking up the amazing circumstance of the 1 infected chicken that just happened to be undercooked and just happened to be earten only by one family.......


.
The chicken that happened to be H5N1 infected, that wasn't inactivated by cooking, but didn't cause disease in the chefs or any other employees or customers of the restaurant, or anyone eating dark meat!

Moreover the H5N1 was so virulent that it caused symptoms within 24 hours for the son, but took 11 days to producie symptoms in the father.

(H5N1 is ALL about politics - no science required).
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Human antibodies used to treat current China H5N1 patient

Takungpao - 2007-12-11

Jiangsu confirmed the second case of human bird flu patients Lu Wei currently stable condition. According to reports, Lu Wei's body temperature had been normal, lung inflammation has also begun to improve, and to normal eating, the patients also very emotional stability. Contain avian influenza antibodies in human serum, to play a key role in the treatment.
According to well-informed sources, Lu Wei on December 3 night fever symptoms, throat irritation at the same time, malaise and other symptoms, that is, "double pneumonia under" hospital treatment.
The infection was diagnosed as highly pathogenic avian influenza, the medical community for his treatment of highly valued. Chinese Health Minister Chen Zhu personally head of the expert group, and specifically for that lived in Nanjing for several days, several participants discussed cases, the illness seriously listen to expert advice and analysis, and medical experts to discuss development of treatment programs.

Minister of Health and head of the experts
According to reports, because lung inflammation, Lu Wei displayed in the large shadow of experts to him in a targeted manner to the antiretroviral treatment, nutrition support and hormone treatment, the daily infusion, and in accordance with conditions to constantly adjust medication now inflammation has been gradually improving.
According to the expert revealed in treatment, patients currently in stable condition and no complications, but will continue to observe the situation in the future. The expert easily said, "is not an issue."

Rescue volunteer blood donors vaccine
According to reports, when Lu Wei illness was diagnosed, his relatives immediately on the Internet in search avian influenza antibodies and the blood type matching with him, they first found a 44-year-old farmer, who farmers are suffering from bird flu after successful treatment of others transfusion, but, in any case do work, the farmers are reluctant to lose their serum Lu Wei.
Later, a hospital laboratory work in the volunteers, he had a bird flu vaccine injection, blood containing the body of the anti-bird flu, he happened to the blood type is B, and B-type blood Lu Wei anastomosis. Thus, in two to Lu Wei importation of all 200 ml serum, a total of 400 ml.
Allegedly, it was exactly these 400 ml containing avian influenza antibodies in serum treatment of Lu Wei's success played a key role.
Insiders disclosed that the first cases of people who died of highly pathogenic avian flu patients??, because the cause of death is not timely and correct treatment, because he incidence, all of them did not expect the bird flu is only in his when aware of the death fast, but already too late to save.

But Grandpa off at the deceased cremated
According to relatives said they join a family of four individuals is playing out in recent years in this family is very rare, because we all usually busy all the time together total less than together.
This family insider saddened by the unfortunate experience it, It is understood that ?? cremation when all relatives were not allowed to look at the (medical observation in isolation in), only that time had not been contacted and the grandson of a person wearing isolation Grandpa He was seen off at the clothing.
According to another report, Eating of chicken and the ??'s mother and girlfriend blood samples were sent to Beijing test results are negative. Medical experts have said that this is perhaps her two are not susceptible because of the crowd.

http://www.takungpao.com/news/07/12/11/ZM-835279.htm

hat-tip to christian.
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Also this thread:

dated March 2006

"Horse antibodies 'protect against bird flu'




Antibodies derived from horses could help protect against avian flu, new research has found.

Scientists in China found that by injecting horse antibodies into mice infected with the H5N1 strain, it stopped the animals dying from the virus....."


http://www.flutrackers.com/forum/showthread.php?t=3318
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

WHY a horse???? :confused:

What is different about horse anitbodies as compared to other mammalian antibodies?

.
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

WHY a horse???? :confused:

What is different about horse anitbodies as compared to other mammalian antibodies?

.

I think they used horse because of previous success:

"...In the setting of viral infection, equine antiserum has been applied as an antiviral regimen to control infection by ebola [23], rabies [24,25], hepatitis B virus [26,27] and HIV [28,29]...."
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

<TABLE class=RedTableBorder style="HEIGHT: 483px" cellSpacing=0 cellPadding=0 width="100%" border=0><TBODY><TR style="PADDING-LEFT: 10px" vAlign=top><TD class=articalTitle align=middle><TABLE cellSpacing=0 cellPadding=0 width=430 border=0><TBODY><TR><TD class=dates id=hDate height=27>
Published: Tuesday, 11 December, 2007, 08:19 AM Doha Time​
</TD></TR></TBODY></TABLE></TD></TR><TR style="PADDING-RIGHT: 12px; PADDING-LEFT: 10px"><TD class=articalBody id=artical1 vAlign=top height=345>BEIJING: The latest human cases of bird flu in China appeared to be isolated events with no other people affected and no reported outbreak of the disease among poultry, the government said yesterday.

A 24-year-old man in eastern Jiangsu province died from bird flu on December 2, and authorities announced on Friday last week that his father also had the H5N1 strain of the virus, raising fears of human-to-human transmission.

Health ministry spokesman Mao Qun'an told reporters yesterday the father, surnamed Lu, 52, was recovering from the virus and that there was no evidence the man had contracted the disease from his son. "There is no biological basis for (the theory of) human-to-human transmission," Mao said.

The H5N1 strain has passed from human to human only in very rare cases and scientists fear that such a transmission could become more efficient and widespread through mutation, causing a global pandemic.

Mao said the strain that killed the son had not mutated from H5N1.

He said 34 people who had close contact with the father and the son were being kept under observation but none of them had shown symptoms of the disease.

There is no report of bird flu outbreaks among poultry in Jiangsu province either, he added.

This followed a familiar pattern in China where humans have contracted the disease in an area where there have been no reported outbreaks among poultry.

The father-son case has brought reports of human cases of bird flu in China to 27 since 2003. Seventeen of those people have died.

.
</TD></TR></TBODY></TABLE>
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

【大公network in Jiangsu - In view of the past week have confirmed that a father and son infected with the H5N1 avian influenza, the Hong Kong Hospital Authority today launched a three-week enhanced surveillance plan, pay attention to the pneumonia patients in public hospitals.

The government held the avian flu inter-departmental meeting to assess Jiangsu has one pair of the latest bird flu situation in the meeting, including the Food and Health Bureau, Hospital Authority, Agriculture, Fisheries and Conservation Department and Food and Environmental Hygiene Department.

Center for Health Protection Consultant张竹君said, is to keep in touch with the Chinese Ministry of Health, understanding Jiangsu two bird flu cases.

张竹君noted that the Department of Health has asked the airlines, distributed leaflets to the health of passengers between Jiangsu and consultations with the public hospitals, to strengthen the monitoring pneumonia cases, special attention from Jiangsu Province to Hong Kong with pneumonia symptoms and the passenger, if the patient before the onset 7 days went to Jiangsu, and pneumonia of unknown source of the disease, public hospitals must be reported to the HA's online reporting system and monitoring of communicable diseases.

Reportedly, the Chinese Ministry of Health of Jiangsu Province man died of bird flu cases that the virus is a bird-derived and found no mutation of the virus, the father of the deceased are investigating the source of infection.

"Central News Agency" Hong Kong 11 Apr

Note: [大公network - the New York Stock Exchange - Mexico, non-primer, "Ta Kung Pao," he said.

http://www.takungpao.com/news/07/12/11/ZM-835603.htm
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

No human-to-human transmission confirmed in new China bird flu cases

China's health authorities say no human-to-human transmission has been confirmed in two human cases of bird flu.

Officials say the means of transmission in the cases involving two family members remain unknown. The epidemiological investigation shows the father could have become infected through close contact with his son.

But it is also possible both men were either infected by the same virus source or separately from different sources. An investigation is underway.

The 24 year old man died December 2nd. His father is in stable condition and showing signs of improvement.

The latest cases have brought the number of confirmed human infections of bird flu in China to 27 since 2003, with 17 deaths

.
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Only for a note: the Jiangsu province and Nanjing are both areas with very high population density. This scenario is ideal for a widespread epidemic of a respiratory pathogen. If the cluster initiated by father and son derives from a virus with enhanced h2h transmission capability, same cluster will grow in next few days or weeks, without any press release or commentary can stop it.
Converserly, if a poultry source is the culprit, more sporadic cases are anticipated.
Recently, chinese researchers published an article with mentions to a novel A/H9N2 virus strain with enhanced affinity with upper respiratory tract cells of humans and internal avian-like gene sequences.
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Only for a note: the Jiangsu province and Nanjing are both areas with very high population density. This scenario is ideal for a widespread epidemic of a respiratory pathogen. If the cluster initiated by father and son derives from a virus with enhanced h2h transmission capability, same cluster will grow in next few days or weeks, without any press release or commentary can stop it.
Converserly, if a poultry source is the culprit, more sporadic cases are anticipated.
Recently, chinese researchers published an article with mentions to a novel A/H9N2 virus strain with enhanced affinity with upper respiratory tract cells of humans and internal avian-like gene sequences.

(1.1): Arch Virol. 2007 Nov 15; [Epub ahead of print]
Genetic analysis of four porcine avian influenza viruses isolated from Shandong, China.

Shi WF, Gibbs MJ, Zhang YZ, Zhang Z, Zhao XM, Jin X, Zhu CD, Yang MF, Yang NN, Cui YJ, Ji L.
Institute of Life Sciences, Taishan Medical College, Shandong Tai?an, China.

A Bayesian phylogenetic analysis of eight separate gene segments indicated A/Swine/Shandong/2/2003 (H5N1), A/Swine/Shandong/na/2003 (H9N2), A/Swine/Shandong/nb/2003 (H9N2) and A/Swine/Shandong/nc/2005 (H9N2) probably represent two multiple reassortant lineages, that had not been described before, with genes coming from H5N1, H9N2 and other lineages from poultry in Asia.

Amino acid motifs within the haemagglutinin sequence of A/Swine/Shandong/nb/2003 suggested it may be able to infect people, whereas the sequences of the other three isolates suggested they would not have had that capability.

Our analysis emphasizes the need for a comprehensive study of the interactions between H5N1 and H9N2 viruses in Asia that includes sequencing and phylogenetic investigation.

PMID: 18000640 [PubMed - as supplied by publisher]

(from DAYS OF THE COMET - RESEARCH ARTICLES ABSTRACT (1859), 1.1, http://hygimia69.blogspot.com/2007/11/days-of-comet-research-articles_19.html
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Only for a note: the Jiangsu province and Nanjing are both areas with very high population density. This scenario is ideal for a widespread epidemic of a respiratory pathogen. If the cluster initiated by father and son derives from a virus with enhanced h2h transmission capability, same cluster will grow in next few days or weeks, without any press release or commentary can stop it.
Converserly, if a poultry source is the culprit, more sporadic cases are anticipated.
Recently, chinese researchers published an article with mentions to a novel A/H9N2 virus strain with enhanced affinity with upper respiratory tract cells of humans and internal avian-like gene sequences.

(1-4): J Virol. 2007 Jul 25; [Epub ahead of print]
The genesis and evolution of H9N2 influenza viruses in poultry from southern China, 2000 to 2005.

Xu KM, Smith GJ, Bahl J, Duan L, Tai H, Vijaykrishna D, Wang J, Zhang JX, Li KS, Fan XH, Webster RG, Chen H, Peiris JS, Guan Y.
International Institute of Infection and Immunity, Shantou University, Shantou, Guangdong 515031, China; State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, Li Ka Sing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pokfulam, Hong Kong SAR, China; and Virology Division, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee 38105.

-

H9N2 influenza viruses have become established in terrestrial poultry in recent two decades in different Asian countries.

Our previous study demonstrated that quail harbor increasing diversity of novel H9N2 reassortants, including both Chicken/Beijing/1/94 (Ck/Bei-like) and Quail/Hong Kong/G1/97 (G1-like) viruses.

However, since 1999 the genesis and evolution of H9N2 viruses in different types of poultry have not been systematically investigated.

In the present study, H9N2 viruses isolated from chicken, duck and other minor poultry were genetically and antigenically characterized.

Our findings demonstrate that Ck/Bei-like H9N2 viruses have been introduced into many different types of poultry including quail, partridge, chukkar, pheasant, Guinea fowl and domestic duck in southern China, while the G1-like viruses were commonly detected from quail, less frequently detected in other minor poultry and not detected in chicken and duck.

Genetic analysis revealed 35 genotypes of H9N2 viruses, including 14 novel genotypes that have not been recognized before.

Our results also suggested that two-way interspecies transmission exist between different types of poultry.

Our study demonstrated that the long-term co-circulation of multiple virus lineages (e.g. H5N1 and H9N2 viruses) in different types of poultry have facilitated these frequent reassortment events that were mostly responsible for current great genetic diversity of H9N2 and H5N1 influenza viruses in this region.

This situation favors the emergence of influenza viruses with pandemic potential.

-

PMID: 17652402 [PubMed - as supplied by publisher]

(from http://hygimia69.blogspot.com/2007/07/in-this-post-1-research-articles_31.html )
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Google-translated from Chinese:

Nanjing bird "suspect" Jiaohua chicken
Dec 10, 2007

On 7 Jiangsu was the second confirmed case of human bird flu patients had to verify the identity, the name of Lu Wei [the father]. It is understood that Lu Wei due to a celebration of his son 陆侃 obtain college, especially their love Eating of chicken to the Confucius Temple in Nanjing Food stores, eating one of Jiaohua not fully cooked chicken. The following day, 陆侃 began fever and was sent to the Jiangsu Provincial People's Hospital, the results died. An Min Chen Nanjing 9 Sep

Lu Wei [the father], served as the Nanjing Military Region, director of communications repair job, intermediate grade last year to retirement age. He is currently Nanjing infectious disease hospital for treatment, according to sources, Lu Wei was reported in critical condition, but after Jiangsu Province and the Nanjing Military Region with the full medical experts rescue, now out of danger, his condition has stabilized, and getting better.

Rescue experts full mobilization authority

The Mainland's Lu Wei treatment is clearly a high degree of attention, Jiangsu set up a special rescue team, the mobilization of the Jiangsu Provincial People's Hospital, Nanjing Gulou Hospital in Nanjing and the Nanjing Military Region General Hospital and a number of hospital respiratory and other related specialties is the clinical experience rich authoritative experts have repeatedly collective consultation, careful development of treatment programs. Medical experts have devoted every night meetings, analysis, discussion Lu Wei's condition, and the timely adjustment of treatment programs.

It has been revealed that the Ministry of Health in Beijing also sent medical experts made a special trip to consultation. According to sources, at present Lu Wei's condition has stabilized, but medical experts are not taken lightly, they are still waiting 24 hours a day in the rotation Lu Wei bed, and closely observe the condition, and take immediate measures to prevent there repeated illness.

According to their relatives disclosure, Lu Wei's son, named 陆侃, this year 24-year-old. Academic performance has not been good, but through the efforts, this year just to acquire the Nanjing University Adult Education College, a people that end very excited. To celebrate 陆侃 in the Billboard parents specifically with him and his girlfriend to join the downtown Nanjing Confucius Temple play, the four individuals in the catering shop Confucius Temple eating wrapped with a thick layer of mud outside the Jiaohua chicken.

Eating of chicken to celebrate his son was admitted to University

According to analysis, this may be precisely because of the parcel outside the chicken and thick mud caused not fully cooked chicken. Eating of chicken and the next day, 陆侃 began fever, body temperature rapidly increased. People in Jiangsu Province were sent to hospital for emergency treatment, the results died.

As for why the incidence is 陆侃 First, his relatives said 陆侃 girlfriend custody of the two pet dogs, because she is foreigners, Nanjing relevant provisions restricting the number of dogs. In order to avoid detection, she "evacuation" of a foster 陆侃 home. To Eating of chicken in the 20 days before 陆侃 was that the one small dogs, for the prevention of rabies, he was injecting rabies vaccine, in accordance with the regulations must play five needles at a time when he had four consecutive injection of rabies vaccine, body the immunity is at the lowest point.

Be sent to the hospital for emergency treatment, and not be treated as avian flu treatment, doctors had suspected he is suffering from the plague [or rabies?].

His son suddenly died, my parents were very sad. Eating of chicken after the sixth day, when the father of Lu Wei fever, there is no cure heart. The urged acquaintances or in the next, he was to go to the hospital treatment.

Their relatives said Lu Wei a special love Eating of chicken, refrigerator equipment are scrapping good chicken. Precisely for this reason, not acquaintances of suspected bird flu, the results Lu Wei went to the Infectious Diseases Hospital in Nanjing, the diagnosis of avian flu.

Eating of chicken and the incidence of four men and women were found to be well

Curiously, with the Eating of chicken to the four individuals, two men have incidence, and the two women have the slightest okay. It has been revealed that 陆侃 girlfriend eat particular, but something has not.

It is learned that Lu Wei Lee, and his wife is also not related symptoms, but she has been isolated observation. Her cell phone has been closed, and she could not contact the outside world.

Wife [mother] of hospital physicians for the brain

Lu Wei after admission, as a clear diagnosis, the doctor immediately gave him lose the avian influenza antibodies and B-type blood albumin, and other symptomatic, due to drugs, because of medical treatment and proper measures, so stable condition.

Lu Wei sudden disaster to a blow is obviously heavy. Originally This is a very happy family, Lu Wei Lee, the wife [mother of 1st victim] of Canada, was born in September 1955, Shanxi Yicheng, is the Nanjing Brain Hospital Physical Diagnosis by the Deputy Director, the Deputy Director of physicians.

http://www.takungpao.com/news/07/12/10/MW-834827.htm
Here's a translation/interpretation of the story by SusanC -- a (native?) Chinese speaker:
here's the story...

and it seems pretty coherent to me.

To celebrate the son's acceptance to university, the family went to pay tribute at the Confucius temple (a tradition because Confucius was a most revered scholar). They went to a restaurant and ordered a local traditional dish called "Beggar's chicken". The chicken is covered with layers of clay/earth and cooked slowly in an earthen oven. This makes the meat very tender, and is particularly favored by those who like the meat to be JUST cooked, not over-cooked.

The problem is, since it is all covered up, you can't really test if the meat is fully cooked. Hence it IS very likely that they did have undercooked chicken.

The son developed fever the next day. The father developed fever the 6th day (which is contrary to official reports, I think), but since the son was quite ill by then, the father couldn't be bothered to seek treatment for himself.

The reference to the dog: the son had been bitten by his girlfriend's dog 20 days before that meal. He had been receiving rabies vaccine for this reason, and the newspaper is speculating that this might have reduced his immune response, as an explanation for why he was the only one (at least initially) to come down with fever.

Also, according to other relatives, this family enjoy eating chicken. Because of this, when the son's fever did not improve, someone asked them whether it might be bird flu. That was the reason why he eventually went to seek treatment at an infectious disease hospital.

Which IMO tells us how hard it is to get a case properly diagnosed, and how many others we might be missing.

The father was once said to be in serious condition, but now stabilized. He is under the care of a large team of physicians from the military (military doctors and hospitals frequently have the highest standards), who are maintaining round the clock close observation.
Also...
something interesting...

the mother who is also under quarantine and observation, is apparently a neurologist.

Sounds like a solid professional middle class family living in an urban setting. Not like the backyard chicken farmer situation at all.
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Thanks to (in no particular order): Theresa42, Dutchy, Ironorehopper, AnneZ, Treyfish, AlaskaDenise, Niko, Hawkeye, Niman, John W, Laidback Al, and SusanC for contributing to this effort to ascertain the truth.
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Ditto the thanks from P4P. :tiphat:
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

... MANY H5N1 cluster members who are not blood relatives, the cases are confirmed, public, and well known to those knowledgeable about this subject.

Which clusters exhibited H2H among people who were not blood relatives?

Which clusters exhibited H2H among people not living in the same household?

J.
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Which clusters exhibited H2H among people who were not blood relatives?

Which clusters exhibited H2H among people not living in the same household?

J.
Off the top of my head

Family of five in Haiphong in 2005 (mother, father, and three children - all H5N1 confirmed and all recovered)

Azerbaijan cluster in 2006 included a friend - infections over an extended period - most died.

Cluster in Vietnam in 2005 involving two siblings and nurse. All were positive and all recovered, although one additional nurse with symptoms tested negative.
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

Off the top of my head

Family of five in Haiphong in 2005 (mother, father, and three children - all H5N1 confirmed and all recovered)

Azerbaijan cluster in 2006 included a friend - infections over an extended period - most died.

Cluster in Vietnam in 2005 involving two siblings and nurse. All were positive and all recovered, although one additional nurse with symptoms tested negative.


Link to H5N1 family clustering article:
http://www.cdc.gov/ncidod/EID/vol11no11/05-0646.htm
 
Re: China: Man Dies; Infected Father "Improving"; More Suspects

The dog bite / rabies shots / short incubation - 1 day / long incubation - 11 days / white meat / dark meat proof on common source will give the duck blood pudding yarns a run for their money.

I'll help them cover more bases: one glop of pond mud used on chicken may have been contaminated with the waste of the H5N1 infected wild fowl
 
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