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China - Hongzhou Lu recommendations for peak of flu season: timely antiviral treatment of patients

Pathfinder

Editor, Senior Moderator
Translation Google

National influenza peak season Lu Hongzhou recommendations: timely anti-viral treatment of patients


January 22, 2018 Source: People's Network - Shanghai Channel

People's Network Shanghai January 22 (Ge Junjun) into the winter, many people have been hit by the flu, leading to cough, high fever. Some people have a fever, the family fell ill; more than many kindergartens, a class half of the children at home to rest treatment. The results of the domestic influenza surveillance showed that the recent influenza epidemic peaked in both northern and southern China. The proportion of outpatient and emergency flu-like cases reported by sentinel hospitals was higher than that of the same period in the past three years. The positive rate of influenza virus detection reached the peak level in previous years, Upward trend.

Early medication to prevent flu

"At present, 40% -50% are influenza, and others are basically common cold, which is generally not contagious." Lu Hongzhou, party secretary of Shanghai Public Health Clinical Center, is also the winner of the 2017 National Science and Technology Progress Award Grand Prize. He said that through the pharynx Pain, cough, fever and other symptoms, people are hard to identify the flu or the common cold.

High season of flu, children get together a cold, anxious young parents waiting in line in the emergency room. As long as one child in the waiting crowd suffers from the flu, other children are highly likely to be infected.

"One sneeze of a child sends out hundreds of millions of viruses, and within a distance of 1.8 meters, as many as 1,000 viruses are sucked in, other children become infected, especially when grandparents, mom and dad are accompanied at the same time and are particularly vulnerable to widespread virus Popular. "Lu Hongzhou pointed out that, whether it is a flu, after a cold must be wearing masks in public places. In case of cough, pay attention to cough etiquette, do not cough to the flu virus to others.

Oseltamivir (Tamiflu) is a cure for the virus and is generally effective against influenza A and B viruses and oseltamivir. Lu Hongzhou actively advocated the promotion of the use of oseltamivir, influenza early treatment and post-exposure prophylaxis. His medication is based on: "early use, as early as early good. In addition, the drug has no obvious side effects, the elderly pregnant women generally apply."

It is reported that neuraminidase inhibitors such as oseltamivir, zanamivir, and peramivir are effective therapies for influenza. In the early stage, the use of anti-influenza virus drugs within 48 hours of onset can significantly reduce the severity of influenza and The incidence of death.

However, it is sometimes difficult to buy anti-influenza drugs such as oseltamivir in hospitals because of tight supply. In response to this situation, Lu Hongzhou recommended several early available cold medicine can be used, such as Shufeng detoxification capsules, and even Huaqingwen capsule can also play a role in relieving symptoms.

This winter, the flu virus is changing

At the time of the SARS epidemic in 2003, from the onset of human history and the stepping down of Lu Hong Chau's mission, he was accompanied by a World Health Organization (WHO) expert. It is precisely because of its rich clinical experience and the awareness of spotting the outbreak of the epidemic. The virus samples collected were identified as the new H7N9 bird flu virus and the first case of human H7N9 bird flu in the world.

A large number of deaths caused by the case of influenza A "guilt" is even more serious, because the type of influenza virus mutation frequency is particularly high, the gene encoding HA or NA protein mutation occurs rapidly. When a host cell is infected with two different influenza viruses, the genomes of the two viruses are prone to recombine. Influenza viruses from different hosts, such as birds, pigs and humans, are prone to genetic mixing and recombination.

As for influenza B, it was thought that it would only infect people in the past. However, some studies have shown that influenza B virus can also cause the seal flu. Influenza B virus is not as diverse as the influenza A virus, mysterious and "wind trouble", its host specificity is strong, that only infected people or seals.

National Health Planning Commission announced the new diagnosis and treatment of influenza program

According to a recent warning issued by the Shanghai Municipal Center for Disease Control and Prevention, Shanghai has now entered the peak season of influenza with the "three-way merging" of Influenza A, Influenza A (H3N2) and Influenza A (H1N1) viruses. However, recent Influenza B virus-based disease.

Lu Hongzhou said influenza B is characterized by acute onset, patients with chills, fever, body temperature rose in the hours to 24 hours, reaching 39 ℃ ~ 40 ℃ or even higher. Patients may be accompanied by headache, body aches, fatigue and loss of appetite, etc., but mild respiratory symptoms, usually only throat, sore throat, dry cough, may have diarrhea. Even if the flu in this winter looks "massive", for the moment, it does not mean that the current flu will be hard to cure or cause a big outbreak.

Recently, the National Health and Family Planning Commission formulated and published the "Influenza Treatment and Treatment Plan (2018 Edition)" on the basis of previous guidelines on influenza treatment. It is understood that the new program in addition to further define the definition of flu, symptoms, latency, but also added some new content. Patients who require antiviral therapy in a timely manner: within 48 hours of onset of antiviral therapy can reduce influenza complications, more than 48 hours of severe patients can still benefit from antiviral therapy. Patients without high-risk factors for severe influenza, the onset time of less than 48 hours, to shorten the course of the disease, reduce complications can also be antiviral therapy.

Secondly, only the neuraminidase inhibitor (NAI) is recommended for the anti-influenza virus drugs in the new treatment plan because these drugs are effective against influenza A and B viruses, including oseltamivir (Tamiflu) Namivir, peramivir and others. One of the top ranked is oseltamivir (Tamiflu), and even star antiviral drugs such as Qinghua Capsules have also been included. It is noteworthy that the so-called "panacea" Radix, this time has not been recommended by the new program.

Due to the high prevalence of influenza in children this winter, general hospital pediatrics and various children's hospitals are overcrowded. The new program released for the first time this year recommended the children's anti-flu proprietary Chinese medicines and reminded children not having any indications Drugs should not be used for children. Among them, children's optional medicine for children Hyperactivity Kechuan oral liquid, children anti-sense particles, children Qiao Qiao Qingre particles.

Lu Hong-zhou suggested that because of the self-healing nature of the flu, it is not necessary for everyone to eat anti-influenza drugs. It is only recommended for people at high risk, such as the elderly, children or people with low immunity, but the dose and course of treatment need to be under the guidance of a doctor Take.

http://sh.people.com.cn/n2/2018/0122/c134768-31168901.html
 
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