Commonground
Senior Moderator
21 Jun, 2020
Excerpts:
Since the latest coronavirus outbreak was reported at the Xinfadi wholesale food market in Beijing, 227 new infections have been confirmed and more than 2.3 million residents have been tested for Covid-19 in a bid to contain the spread.
Health authorities identified the infection in a number of locations at the market, including inside the mouths of imported salmon. The whole genome sequencing data of samples from the first three patients have been released and they all contained the D614G mutation.
-snip-
In the Chongqing study, the antibodies generated by three patients failed to suppress the mutated strain, with one sample showing almost zero effect.
The researchers then tried to infect host cells with the mutant and normal strains. The mutant’s entry efficiency was 2.4 times higher.
-snip-
“Given the evolving nature of the SARS-CoV-2 RNA genome, antibody treatment and vaccine design might require further consideration to accommodate the D614G and other mutations that may affect the immunogenicity of the virus,” Huang said.
About 10 per cent of the people infected by the new outbreak in Beijing are in a critical condition, according to the city’s health authorities, and medical teams from across the country have been flown into to help with the aid effort.
https://www.scmp.com/coronavirus/gre...be-defenceless
Excerpts:
- Antibodies found in blood of people who have fought disease failed to stop D614G, Chinese scientists say
- Mutant form identified in genetic data of samples collected at Xinfadi food market in Beijing where latest outbreak began
Since the latest coronavirus outbreak was reported at the Xinfadi wholesale food market in Beijing, 227 new infections have been confirmed and more than 2.3 million residents have been tested for Covid-19 in a bid to contain the spread.
Health authorities identified the infection in a number of locations at the market, including inside the mouths of imported salmon. The whole genome sequencing data of samples from the first three patients have been released and they all contained the D614G mutation.
-snip-
In the Chongqing study, the antibodies generated by three patients failed to suppress the mutated strain, with one sample showing almost zero effect.
The researchers then tried to infect host cells with the mutant and normal strains. The mutant’s entry efficiency was 2.4 times higher.
-snip-
“Given the evolving nature of the SARS-CoV-2 RNA genome, antibody treatment and vaccine design might require further consideration to accommodate the D614G and other mutations that may affect the immunogenicity of the virus,” Huang said.
About 10 per cent of the people infected by the new outbreak in Beijing are in a critical condition, according to the city’s health authorities, and medical teams from across the country have been flown into to help with the aid effort.
https://www.scmp.com/coronavirus/gre...be-defenceless