tetano
Editor, Senior Moderator
China CDC Wkly
. 2021 Dec 3;3(50):1071-1074.
doi: 10.46234/ccdcw2021.259.
Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants - China, 2021
Kangguo Li[SUP] 1 [/SUP], Zeyu Zhao[SUP] 1 2 [/SUP], Hongjie Wei[SUP] 1 [/SUP], Jia Rui[SUP] 1 [/SUP], Jiefeng Huang[SUP] 1 [/SUP], Xiaohao Guo[SUP] 1 [/SUP], Yichao Guo[SUP] 1 [/SUP], Shiting Yang[SUP] 1 [/SUP], Guzainuer Abudurusuli[SUP] 1 [/SUP], Li Luo[SUP] 1 [/SUP], Xingchun Liu[SUP] 1 [/SUP], Yao Wang[SUP] 1 [/SUP], Jingwen Xu[SUP] 1 [/SUP], Yuanzhao Zhu[SUP] 1 [/SUP], Meng Yang[SUP] 1 [/SUP], Tianlong Yang[SUP] 1 [/SUP], Weikang Liu[SUP] 1 [/SUP], Bin Deng[SUP] 1 [/SUP], Chan Liu[SUP] 1 [/SUP], Zhuoyang Li[SUP] 1 [/SUP], Peihua Li[SUP] 1 [/SUP], Shanshan Yu[SUP] 1 [/SUP], Zimei Yang[SUP] 1 [/SUP], Yanhua Su[SUP] 1 [/SUP], Benhua Zhao[SUP] 1 [/SUP], Yan Niu[SUP] 3 [/SUP], Tianmu Chen[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China. The study aims to estimate effectiveness of booster vaccines for high-risk populations (HRPs).
Methods: A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed (SEIAR) model was developed to simulate scenarios of effective reproduction number (R [SUB]eff[/SUB] ) from 4 to 6. Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.
Results: Our model showed that we could not prevent outbreaks when covering 80% of HRPs with booster unless R [SUB]eff[/SUB] =4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%. The results were consistent when the outcome index was confirmed cases or asymptomatic cases.
Conclusions: An ideal coronavirus disease 2019 (COVID-19) booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China. Accordingly, the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups.
Keywords: China; booster; high-risk population; vaccinations.
. 2021 Dec 3;3(50):1071-1074.
doi: 10.46234/ccdcw2021.259.
Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants - China, 2021
Kangguo Li[SUP] 1 [/SUP], Zeyu Zhao[SUP] 1 2 [/SUP], Hongjie Wei[SUP] 1 [/SUP], Jia Rui[SUP] 1 [/SUP], Jiefeng Huang[SUP] 1 [/SUP], Xiaohao Guo[SUP] 1 [/SUP], Yichao Guo[SUP] 1 [/SUP], Shiting Yang[SUP] 1 [/SUP], Guzainuer Abudurusuli[SUP] 1 [/SUP], Li Luo[SUP] 1 [/SUP], Xingchun Liu[SUP] 1 [/SUP], Yao Wang[SUP] 1 [/SUP], Jingwen Xu[SUP] 1 [/SUP], Yuanzhao Zhu[SUP] 1 [/SUP], Meng Yang[SUP] 1 [/SUP], Tianlong Yang[SUP] 1 [/SUP], Weikang Liu[SUP] 1 [/SUP], Bin Deng[SUP] 1 [/SUP], Chan Liu[SUP] 1 [/SUP], Zhuoyang Li[SUP] 1 [/SUP], Peihua Li[SUP] 1 [/SUP], Shanshan Yu[SUP] 1 [/SUP], Zimei Yang[SUP] 1 [/SUP], Yanhua Su[SUP] 1 [/SUP], Benhua Zhao[SUP] 1 [/SUP], Yan Niu[SUP] 3 [/SUP], Tianmu Chen[SUP] 1 [/SUP]
Affiliations
- PMID: 34934519
- PMCID: PMC8671839
- DOI: 10.46234/ccdcw2021.259
Abstract
Introduction: Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in China. The study aims to estimate effectiveness of booster vaccines for high-risk populations (HRPs).
Methods: A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed (SEIAR) model was developed to simulate scenarios of effective reproduction number (R [SUB]eff[/SUB] ) from 4 to 6. Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.
Results: Our model showed that we could not prevent outbreaks when covering 80% of HRPs with booster unless R [SUB]eff[/SUB] =4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%. The results were consistent when the outcome index was confirmed cases or asymptomatic cases.
Conclusions: An ideal coronavirus disease 2019 (COVID-19) booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China. Accordingly, the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups.
Keywords: China; booster; high-risk population; vaccinations.