China - 1st H7N4 case confirmed by Hong Kong CHP, Jiangsu province - February 14, 2018

[sharon sanders]

• A 68-year-old woman infected with the new H7N4 strain of bird flu in Jiangsu Province is the world's first case
• 2018/2/14 22:03:53 source: Zhangjiakou fresh things browse: 863
• (Original title: 68-year-old woman infected with new bird flu H7N4 in Jiangsu Province, the world's first case)
  The Center for Health Protection (CHP) of the Department of Health received a notification today (February 14) from the National Health and Family Planning Commission (SPS) of the National Health and Well-being Commission (CFS) for the confirmation of a human case of Influenza A (H7N4) infection from February 10 to 14 And strongly urge members of the public to keep their personal, food and environmental hygiene at all times and to prevent bird flu, whether on local or overseas trips.
  According to the information from the National Health and Family Planning Commission, this is the first case of human being bird flu (H7N4) in the world. The case involved a 68-year-old woman living in Liyang City, Changzhou City, Jiangsu Province. She was hospitalized on December 25 last year and was admitted to hospital on January 1 this year. She was discharged on January 22 after treatment. Before the onset of the patient had contact with live poultry. All her close contacts did not show symptoms during medical observation.
  According to the Chinese Center for Disease Control and Prevention report, genetic analysis shows that the patient's viral genes are avian origin.
  A spokesman for the CHP said: "All new influenza A viruses, including H7N4, are legally required to be reported as infectious diseases in Hong Kong."
  "In the winter, it is expected that the level of activity of the bird flu virus will be high, based on seasonal epidemics, and citizens are advised not to visit wet markets, live poultry markets or farms if they come to the Mainland or other affected areas. Pay attention to whether there are free-range poultry, do not buy live poultry or slaughter fresh poultry, avoid contact with birds or their droppings, and keep personal and hand hygiene whenever possible.
  After returning to Hong Kong from the affected areas, seek medical advice promptly if symptoms appear and tell them where they have been recently to diagnose and treat the underlying disease as soon as possible. If you have ever seen any live poultry during your trip, you may have to contact your doctor for possible contact with the contaminated environment to help diagnose a possible case of bird flu and to arrange the necessary investigation and appropriate treatment in a timely manner.
  At the local level, the CHP has put in place a series of monitoring and control measures. It will remain vigilant and work closely with the World Health Organization and the relevant health authorities to monitor the latest developments.
  The CHP Harbor Health Service has been implementing health surveillance measures at all control points and has an infrared camera to monitor the temperature of persons entering the country. If any suspected cases are found, patients will be referred immediately to a public hospital for follow-up.
  The Department will continue to post posters and broadcast health information in the immigration lounge, carry out health education on travelers and regularly update the information to the travel trade and other stakeholders.
  Members of the public should keep their personal, hand, food and environmental hygiene at all times and pay attention to the following suggestions when handling poultry:
  Avoid contact with poultry, birds, animals or their droppings;
  
  When buying live chickens, do not touch live chickens and chicken manures, do not blow their tails. Wash stained eggs, wash with detergent, and cook and eat immediately. After touching chicken and egg, wash hands thoroughly with soap and water;
  Egg should be thoroughly cooked until the yolk and protein coagulation, do not eat raw eggs or raw sauces. Cook poultry thoroughly. If there is still pink gravy outflow, or the bone marrow is still bright red, should be re-cooked to fully cooked;
  Wash your hands frequently, especially when touching the mouth, nose or eyes, before handling food or eating, after going to the toilet, after touching public objects such as elevator handrails, lift buttons or door handles, or when hands are contaminated with respiratory secretions, such as coughing or After sneezing;
  If you have symptoms of fever or respiratory tract infection, head to a hospital or clinic and wear a mask to take care of patients with fever or respiratory symptoms.

zhttp://www.zjkonline.com/News/201802/New1558470.html

 

[sharon sanders]

CHP notified of human case of avian influenza A (H7N4) in Mainland
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The Centre for Health Protection (CHP) of the Department of Health (DH) today (February 14) received notification from the National Health and Family Planning Commission (NHFPC) that a human case of avian influenza A (H7N4) was confirmed from February 10 to 14, and reminded the public to maintain strict personal, food and environmental hygiene both locally and during travel.

According to the NHFPC, this is the first case of human infection with avian influenza A (H7N4) in the world. The case involved a 68-year-old female patient living in Liyang in Changzhou of Jiangsu Province who developed symptoms on December 25, 2017. She was admitted to hospital for medical treatment on January 1 and was discharged on January 22. She had contact with live poultry before the onset of symptoms. All her close contacts did not have any symptoms during the medical surveillance period.

According to a report from the Chinese Center for Disease Control and Prevention, upon analysis, the genes of the virus were determined to be of avian origin.

"All novel influenza A infections, including H7N4, are notifiable infectious diseases in Hong Kong," the spokesman for the CHP said.

"Based on the seasonal pattern, the activity of avian influenza viruses is expected to be higher in winter. Travellers to the Mainland or other affected areas must avoid visiting wet markets, live poultry markets or farms. They should be alert to the presence of backyard poultry when visiting relatives and friends. They should also avoid purchasing live or freshly slaughtered poultry, and avoid touching poultry/birds or their droppings. They should strictly observe personal and hand hygiene when visiting any place with live poultry," the spokesman reminded.

Travellers returning from affected areas should consult a doctor promptly if symptoms develop, and inform the doctor of their travel history for prompt diagnosis and treatment of potential diseases. It is essential to tell the doctor if they have seen any live poultry during travel, which may imply possible exposure to contaminated environments. This will enable the doctor to assess the possibility of avian influenza and arrange necessary investigations and appropriate treatment in a timely manner.

While local surveillance, prevention and control measures are in place, the CHP will remain vigilant and work closely with the World Health Organization and relevant health authorities to monitor the latest developments.

The CHP's Port Health Office conducts health surveillance measures at all boundary control points. Thermal imaging systems are in place for body temperature checks on inbound travellers. Suspected cases will be immediately referred to public hospitals for follow-up.

The display of posters and broadcasting of health messages in departure and arrival halls as health education for travellers is under way. The travel industry and other stakeholders are regularly updated on the latest information.

The public should maintain strict personal, hand, food and environmental hygiene and take heed of the advice below if handling poultry:

• Avoid touching poultry, birds, animals or their droppings;
• When buying live chickens, do not touch them and their droppings. Do not blow at their bottoms. Wash eggs with detergent if soiled with faecal matter and cook and consume the eggs immediately. Always wash hands thoroughly with soap and water after handling chickens and eggs;
• Eggs should be cooked well until the white and yolk become firm. Do not eat raw eggs or dip cooked food into any sauce with raw eggs. Poultry should be cooked thoroughly. If there is pinkish juice running from the cooked poultry or the middle part of its bone is still red, the poultry should be cooked again until fully done;
• Wash hands frequently, especially before touching the mouth, nose or eyes, before handling food or eating, and after going to the toilet, touching public installations or equipment such as escalator handrails, elevator control panels or door knobs, or when hands are dirtied by respiratory secretions after coughing or sneezing; and
• Wear a mask if fever or respiratory symptoms develop, when going to a hospital or clinic, or while taking care of patients with fever or respiratory symptoms.

The public may visit the CHP's pages for more information: the avian influenza page, the weekly Avian Influenza Report, global statistics and affected areas of avian influenza, the Facebook Page and the YouTube Channel.
Ends/Wednesday, February 14, 2018
Issued at HKT 18:43

http://www.info.gov.hk/gia/general/201802/14/P2018021400759.htm

 

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Translation Google

Today 09:05 current pulse

Yuan Guoyong: not clear H7N4 virus transmission

In the Mainland, the world's first human case of avian influenza A (H7N4) bird flu was reported. Yuan Guoyong, professor of lectures at the Department of Microbiology of the University of Hong Kong, said on a radio program that the current clinical data on H7N4 are relatively scarce and the route of virus transmission is unclear. The easiest way to eliminate this is No live chicken market supply.

Yuan Guoyong also pointed out that the H7N4 virus, which is only temporarily known to be poultry, will also appear in humans. As the influenza virus will change its genome to adapt to survive, other types of influenza viruses may be found in humans in the future.

http://www2.hkej.com/instantnews/cur...80%94%E5%BE%91

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Wednesday, February 14, 2018
Next article

Human first infected H7N4 Yuan Guoyong refers to the highly pathogenic bird flu worries into endemic (19:00)

A 68-year-old woman from Jiangsu province is diagnosed with H7N4 and is the world's first human case of human infection. Professor Yuan Guoyong, a lecture professor in the Department of Microbiology at the University of Hong Kong, said that H7N4 is a highly pathogenic avian influenza in animals.

Yuan Guoyong said on the commercial program that H7N4 first appeared on Australian animals in 1997 as "HPAI." However, no human infection was reported at the time. However, human beings have been confirmed to have H7N4 infection this time. He said that the temporary H7N4 clinical data is very small, the route of transmission is not clear, but still closely monitor the fever back from the Mainland and so on.

Concerned about the "endemic diseases", Yuan Guoyong pointed out that the mainland has been using the H5N1 bird flu vaccine for the subsequent emergence of the H7N9 bird flu. "When you have more poultry vaccines, there are more antibodies in the bloodstream and the virus will follow With stress changing, because the canal (virus) wants to survive, there are different combinations. "

He described the flu virus as "easy (gene) shuffle", "no matter how clever human beings are and (the vaccine) chase extremely hard to catch up". The simplest solution to this problem is "no live chickens in the market."

https://news.mingpao.com/ins/instantnews/web_tc/article/20180215/s00001/1518656220960

 

[Shiloh]

Source: http://www.who.int/csr/don/22-february-2018-ah7n4-china/en/
[h=1]Human infection with avian influenza A(H7N4) virus ? China[/h] Disease outbreak news
22 February 2018

On 14 February 2018, the National Health and Family Planning Commission (NHFPC) of China notified the World Health Organization (WHO) of one case of human infection with avian influenza A(H7N4) virus. This is the first human case of avian influenza A(H7N4) infection to be reported worldwide.
The case-patient was a 68-year-old woman from Jiangsu Province with pre-existing coronary heart disease and hypertension and she developed symptoms on 25 December 2017. Seven days later, she was admitted to a local hospital for treatment of severe pneumonia and was discharged after 21 days. On 12 February, the Chinese Center for Disease Control and Prevention (China CDC) confirmed that the case-patient?s samples were positive for avian influenza A(H7N4). The NHFPC confirmed the diagnosis on 13 February 2018. The case-patient had reported a history of exposure to live poultry before onset of symptoms.
Genetic sequencing of this A(H7N4) virus shows that all the virus segments originated from avian influenza viruses. This virus is sensitive to adamantanes and neuraminidase inhibitors based on genetic sequencing.
Twenty-eight close contacts of the case-patient have been under medical observation. Among close contacts, no abnormal findings have been found and all throat swabs from her contacts have tested negative.
[h=3]Public health response[/h] The Chinese government conducted a risk assessment, and has enhanced prevention and control measures, surveillance and epidemiological investigations including contact tracing and laboratory testing. Public risk communication and information sharing is ongoing.
WHO is in contact with national authorities and is following the event closely. WHO is facilitating information-sharing with Member States and is closely monitoring the situation, in line with the International Health Regulations (2005).
[h=3]WHO risk assessment[/h] This is the first report of a human case of avian influenza A(H7N4) infection globally and the case reported exposure to live backyard poultry before illness onset. Genetic analysis of this influenza A(H7N4) virus indicates that it is of avian origin.
Close contacts of the case-patient tested negative for avian influenza A(H7N4) and remained asymptomatic. Current evidence suggests that this virus does not have the ability of sustained transmission to humans, thus the likelihood of sustained human to human transmission is low. Any animal influenza virus that develops the ability of human to human transmission can theoretically cause a pandemic.
It is possible that additional human cases of avian influenza A(H7N4) will be detected, however only one human case has been detected so far, and information on the circulation of avian influenza A(H7N4) in birds is not currently available. Further information needs to be gathered to increase the confidence in this assessment.
[h=3]WHO advice[/h] The public should avoid contact with high-risk environments such as live animal markets/farms and live poultry, or surfaces that might be contaminated by poultry feces. Hand hygiene with frequent washing or use of alcohol hand sanitizer is recommended. WHO does not recommend any specific different measures for travellers.
WHO does not advise special screening at points of entry with regard to this event, nor does it recommend that any travel or trade restrictions be applied.

 

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Translation Google

The first human case of H7N4 infection was cured and discharged from close contacts without infection

2018-02-23 15:52:14 Source: Xinhua

Xinhua News Agency, Nanjing, February 23 (Reporter Zhu Xudong) This reporter learned from the CDC of Jiangsu Province on the 23rd that the first case of H7N4 infection in Jiangsu Province was cured and discharged a month ago. Of the 28 people in close contact with him One person infected. Bao Zijun, head of the CDC in Jiangsu Province, said that the current case of human H7N4 infection is a case of the virus can be cured and limited ability to spread.

Patients Tangmou, female, 68 years old, living in Liyang City, Changzhou, Jiangsu Province, before the onset of live contact history. Patients on December 25, 2017 onset, after "severe pneumonia" hospitalization, and the use of Tamiflu for treatment, in January 22, 2018 cured and discharged.

January 3, Changzhou Hospital found an unknown cause of pneumonia patients, a serious condition, history of exposure to poultry, suspected H7N9. However, Changzhou CDC preliminary testing, measured positive for H7, while N9 was negative.

"There are many subtypes of bird flu, of which H has 1-16, N 1-9, different permutations and combinations, there will be more than 100 subtypes." Baozhan Jun said that on January 5, Jiangsu Province CDC review, the results H7 positive, N4 positive, suggesting that H7N4 virus may be.

Bao advocate Jun said that before, there is no domestic or human infection of such viruses reported birds, the international community only sporadic H7N4 virus detected in the specimens. They passed the second generation of the original specimen sequencing, the results also showed that H7N4 virus. January 10, the National Center for Disease Control by fluorescence quantitative PCR and deep sequencing, the final confirmation of the patient's original specimen contains H7N4 virus.

http://www.xinhuanet.com/local/2018-02/23/c_1122442896.htm

 

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H7N4 cases of the world's first human infection has not yet found a case of human transmission

At 19:42 on February 24, 2018 Source: News surging participate in interactive

The world's first human case of H7N4 infection was cured in Changzhou and no human-transmitted cases were found

Yesterday, the reporter learned from Changzhou Third People's Hospital (hereinafter referred to as "Changzhou Hospitals") that the State Health Planning Commission confirmed that one case of human infection with H7N4 bird flu was cured on January 22 in Changzhou!

It is understood that this year, 68-year-old patient Ms. Tang, living in Liyang, Changzhou, Jiangsu, December 25, 2017 onset, fever, chills (cold), fatigue, malaise, cough and other symptoms; , Incontinence, at a local hospital for treatment, after two days of treatment further aggravating the situation, go to Changzhou Hospitals.

Changzhou Hospitals combined with the characteristics of the patient's history, and farming, slaughtering live poultry history, consider the "bird flu" may be immediately admitted to isolation wards, the hospital quickly start public health emergency treatment plan. Disinfection and isolation group strictly in accordance with the requirements of prevention and control of infectious diseases, strengthen disinfection and isolation measures to prevent the spread of the virus; Epidemiological investigation team immediately reported to the higher health administrative departments, collected specimens sent to Changzhou CDC test pathogen; medical treatment expert group is fully responsible for the treatment of patients jobs. The patient's virus samples by the city, provincial and national CDC test, eventually identified as H7N4 virus.

The virus was first detected at a chicken farm in Australia in 1997. The first human case of human H7N4 infection in this case was found to be a case and so far no case of human transmission has been found.

Changzhou Hospital director of infectious diseases, medical experts Xu Tianmin introduction, "the patient admitted to the lung lesions are very extensive, the course of hypoxemia, the condition of life-threatening, admission to intensive care immediately after taking anti-virus, oxygen Treatment, organ function protection and symptomatic support and other treatment. " After full treatment, a week later, the patient's condition was effectively controlled in a timely manner.

For this rescue, the expert group leader Xu Tianmin said: "We refer to H7N9 bird flu and Influenza A H1N1 flu diagnosis and treatment guidelines, but also combined with the hospital treatment experience of such diseases, formed a complete set of emergency treatment measures to deal with More calm and calm. "In recent years, in the face of flu pandemic, director Xu Tianmin and his team face the challenge and actively respond to the successful rescue rate of severe pneumonia 95%, has accumulated rich experience in clinical treatment.

The successful rescue of this case is of great significance to medical professionals in fully grasping the status of such bird flu and formulating prevention and control measures.

It is reported that winter and spring are the high season of influenza. Director Xu Tianmin reminded once again that influenza is a common respiratory disease characterized by short incubation period, strong contagiousness and fast transmission. Almost all people have had flu and most have a good prognosis. However, A small part of the underlying diseases, immune dysfunction and elderly patients will be pneumonia, severe organ damage or even life-threatening, so when the flu fever, cough, chest tightness, or other aggravating symptoms to the hospital in time. The bird flu is a kind of flu, which usually spreads in the birds and does not cause disease to humans. However, the influenza virus will continue to mutate, reorganize and may infect human beings. We pay close attention to such diseases, find out in time, diagnose them early and take corresponding measures, or we can prevent and control them.

【Edit: Wei Wei】

http://www.chinanews.com/jk/2018/02-24/8453822.shtml

 

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[FONT=&#24494]Translation Google[/FONT]
[FONT=&#24494]Jiangsu Province discovers the world's first human case of H7N4 avian influenza virus[/FONT]​

[FONT=&#24494]Author: Science Bulletin Source: micro-channel public number Science Bulletin Date: 2018-08-21 0[/FONT]​

[FONT=&#24494]　　The team of Professor Zhu Fengcai from the Jiangsu Provincial Center for Disease Control and Prevention, the team of the National Center for Disease Control and Prevention, Gao Fu, and the National Influenza Center, Wang Dayan and Liu Jun, teamed up to discover and confirm a gene for wild birds from a respiratory specimen of a severe pneumonia case. The source of the novel recombinant H7N4 influenza virus, which is the first in the world to confirm that the H7N4 avian influenza virus can cause serious human infections.
　　In recent years, incidents of avian influenza infection have continued to occur, and new avian influenza has emerged, seriously threatening public health security.
　　The earliest evidence of avian influenza virus infection can be traced back to 1959. However, it was not until 1997 that the H5N1 virus caused 18 cases in Hong Kong, and 6 of them died, which really sounded the alarm. Since then, more and more avian influenza virus subtypes have been found to infect humans, including H5N6, H6N1, H7N2, H7N3, H7N7, H9N2, H10N8 and so on. Among them, H7 subtype avian influenza is particularly concerned.
　　In 2013, a new type of H7N9 avian influenza virus that infects humans has emerged, resulting in more than 1,500 cases in just a few years, with a mortality rate of more than 30%. At present, with the joint efforts of many ministries, the H7N9 epidemic is basically controlled, but whether there will be a new bird flu virus replacement and popularization has become a new concern.
　　In response to the threat of new infectious diseases including avian influenza, China has established an unexplained pneumonia surveillance system, and Jiangsu Province has further expanded its scope to hospitalized pneumonia surveillance to detect and identify abnormal infections with public health significance at an early stage.
　　Recently, the team of Professor Zhu Fengcai of Jiangsu Provincial Center for Disease Control and Prevention, the team of Academician Gao Fu of the National Center for Disease Control and Prevention, and the team of researchers of National Influenza Center Wang Dayan and Liu Jun discovered and confirmed a base from a respiratory specimen of a severe pneumonia case. Because of the new recombinant H7N4 influenza virus from wild poultry, this is the first time in the world that the H7N4 avian influenza virus can cause serious human infections. Epidemiological investigations and molecular traceability analysis suggest that the virus is likely to be derived from wild birds and transmitted to humans by infecting poultry that are free-range in the wild. Sequence analysis revealed that the virus tends to bind to the alpha-2,3 receptor, is less pathogenic to avian, and sensitive to neuraminidase inhibitors. Further viral gene evolution analysis suggested that the H7 gene of the virus was derived from the Eurasian wild bird, not from the H7N9 virus.[/FONT]

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[FONT=&#24494]Figure: Timeline of the clinical course and key indicators of the H7N4 patient. [/FONT]​

[FONT=&#24494]　　Due to the timely detection and rapid disposal of the case, the patient has recovered and discharged, and the H7N4 virus has not spread further among local birds, nor has it caused more human infections. However, the incident reminds us once again that the evolution of the flu virus has never stopped, the threat of a pandemic has always existed, and we must always be vigilant. The use of clinically unexplained pneumonia surveillance and multi-pathogenic rapid detection platforms and next-generation sequencing technologies can help early identification and rapid response to new influenza viruses with the potential for influenza pandemic.　　
　　The study was published as a cover article in the 16th issue of Science Bulletin 2018. In the same period, I was appraised by the Academician Yuan Guoyong of the University of Hong Kong, saying that “the public health significance of this incident deserves further study. Closer monitoring of wild birds, poultry and human cases should be conducted to judge whether this new recombinant H7N4 avian influenza virus will be Replacing the H7N9 virus has caused new epidemics."[/FONT]




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