tetano
Editor, Senior Moderator
Chest. 2020 Apr 23. pii: S0012-3692(20)30747-9. doi: 10.1016/j.chest.2020.04.015. [Epub ahead of print]
Unexpected Blood Pressure Sensitivity to Angiotensin II in a COVID-19 Patient with ARDS and Septic Shock.
Wang H[SUP]1[/SUP], Das S[SUP]2[/SUP], Wieruszewski PM[SUP]3[/SUP], Taji J[SUP]4[/SUP], Bartlett B[SUP]5[/SUP], Azad N[SUP]1[/SUP], Chowdhury A[SUP]1[/SUP], Kolar G[SUP]1[/SUP], Jain N[SUP]2[/SUP], Subla MR[SUP]6[/SUP], Khan SA[SUP]7[/SUP].
Author information
Abstract
We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite blood pressure sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biologic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.
Copyright ? 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
Angiotensin II; COVID-19; SARS-CoV-2; Septic shock
PMID:32335068DOI:10.1016/j.chest.2020.04.015
Unexpected Blood Pressure Sensitivity to Angiotensin II in a COVID-19 Patient with ARDS and Septic Shock.
Wang H[SUP]1[/SUP], Das S[SUP]2[/SUP], Wieruszewski PM[SUP]3[/SUP], Taji J[SUP]4[/SUP], Bartlett B[SUP]5[/SUP], Azad N[SUP]1[/SUP], Chowdhury A[SUP]1[/SUP], Kolar G[SUP]1[/SUP], Jain N[SUP]2[/SUP], Subla MR[SUP]6[/SUP], Khan SA[SUP]7[/SUP].
Author information
Abstract
We report the case of an 88-year-old man with coronavirus disease 2019 (COVID-19) who presented with ARDS and septic shock. The patient had exquisite blood pressure sensitivity to low-dose angiotensin II (Ang-2), allowing for rapid liberation from high-dose vasopressors. We hypothesize that sensitivity to Ang-2 might be related to biologic effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our case is suggestive of a potential role for synthetic Ang-2 for patients with COVID-19 and septic shock. Further studies are needed to confirm our observed clinical efficacy.
Copyright ? 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.
KEYWORDS:
Angiotensin II; COVID-19; SARS-CoV-2; Septic shock
PMID:32335068DOI:10.1016/j.chest.2020.04.015