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ChemXriv: Homology Models of Wuhan Coronavirus 3CLpro Protease

tetano

Editor, Senior Moderator
preprint submitted on 19.01.2020, 17:20 and posted on 24.01.2020, 21:25 by Martin Stoermer

A regional outbreak of pneumonia in Wuhan, Hubei Province of China in late 2019 was associated with a novel coronavirus. Rapid release of genomic data for the isolated virus enabled the construction of first-generation homology models of the new CoV 3CL[SUP]pro[/SUP] cysteine protease. Whilst the overall viral genome was most closely associated with bat coronaviruses, the main protease is most closely related (96% identity) to SARS CoV protease.


https://chemrxiv.org/articles/Homolo...ooe-U-i1HuCWns
 
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