tetano
Editor, Senior Moderator
Chembiochem
. 2020 Oct 29.
doi: 10.1002/cbic.202000744. Online ahead of print.
Optical Biosensors for Virus Detection: Prospects for COVID-19
Hemanth Maddali[SUP] 1 [/SUP], Catherine E Miles[SUP] 2 [/SUP], Joachim Kohn[SUP] 3 [/SUP], Deirdre Marie O'Carroll[SUP] 4 [/SUP]
Affiliations
Abstract
The recent pandemic of the novel coronavirus disease 2019 (COVID-19) caused massive worldwide disruptions due to the lack of available testing locations and equipment. The use of optical techniques for viral detection has flourished in the past 15 years, providing more reliable, inexpensive, and accurate detection methods. In the current minireview, optical phenomena including fluorescence, surface plasmons, surface-enhanced Raman scattering (SERS), and colorimetry are discussed in the context of detecting virus pathogens. The sensitivity of a viral detection method can be dramatically improved by utilizing materials that exhibit surface plasmons or SERS, but often it requires advanced instrumentation for detection. Although fluorescence and colorimetry lack high sensitivities, they show promise as point-of-care diagnostics because of their relatively less complicated instrumentation, ease of use, lower costs, and they do not require nucleic acid amplification. Advantages and disadvantages of each optical detection method are presented, and prospects for applying optical biosensors in COVID-19 detection are discussed.
Keywords: COVID-19; Fluorescence; Plasmonics; Virus Detection; optical biosensors.
. 2020 Oct 29.
doi: 10.1002/cbic.202000744. Online ahead of print.
Optical Biosensors for Virus Detection: Prospects for COVID-19
Hemanth Maddali[SUP] 1 [/SUP], Catherine E Miles[SUP] 2 [/SUP], Joachim Kohn[SUP] 3 [/SUP], Deirdre Marie O'Carroll[SUP] 4 [/SUP]
Affiliations
- PMID: 33119960
- DOI: 10.1002/cbic.202000744
Abstract
The recent pandemic of the novel coronavirus disease 2019 (COVID-19) caused massive worldwide disruptions due to the lack of available testing locations and equipment. The use of optical techniques for viral detection has flourished in the past 15 years, providing more reliable, inexpensive, and accurate detection methods. In the current minireview, optical phenomena including fluorescence, surface plasmons, surface-enhanced Raman scattering (SERS), and colorimetry are discussed in the context of detecting virus pathogens. The sensitivity of a viral detection method can be dramatically improved by utilizing materials that exhibit surface plasmons or SERS, but often it requires advanced instrumentation for detection. Although fluorescence and colorimetry lack high sensitivities, they show promise as point-of-care diagnostics because of their relatively less complicated instrumentation, ease of use, lower costs, and they do not require nucleic acid amplification. Advantages and disadvantages of each optical detection method are presented, and prospects for applying optical biosensors in COVID-19 detection are discussed.
Keywords: COVID-19; Fluorescence; Plasmonics; Virus Detection; optical biosensors.