tetano
Editor, Senior Moderator
Biomed Environ Sci. 2017 Jan;30(1):68-74. doi: 10.3967/bes2017.009.
[h=1]Characterization of Highly Pathogenic Avian Influenza H5N1 Viruses Isolated from Domestic Poultry in China.[/h] Lai CC[SUP]1[/SUP], Wang KY[SUP]1[/SUP], Chen R[SUP]2[/SUP], Zhang AJ[SUP]3[/SUP], Gu HJ[SUP]1[/SUP], Yin YB[SUP]4[/SUP], Wang DD[SUP]4[/SUP], Liu LL[SUP]4[/SUP], Xing L[SUP]1[/SUP], Tong YG[SUP]1[/SUP], Ma ZJ[SUP]3[/SUP], Yang PH[SUP]5[/SUP], Wang XL[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The highly pathogenic avian influenza (HPAI) H5N1 virus has caused several outbreaks in domestic poultry. Despite great efforts to control the spread of this virus, it continues to evolve and poses a substantial threat to public health because of a high mortality rate. In this study, we sequenced whole genomes of eight H5N1 avian influenza viruses isolated from domestic poultry in eastern China and compared them with those of typical influenza virus strains. Phylogenetic analyses showed that all eight genomes belonged to clade 2.3.2.1 and clade 7.2, the two main circulating clades in China. Viruses that clustered in clade 2.3.2.1 shared a high degree of homology with H5N1 isolates located in eastern Asian. Isolates that clustered in clade 7.2 were found to circulate throughout China, with an east-to-west density gradient. Pathogenicity studies in mice showed that these isolates replicate in the lungs, and clade 2.3.2.1 viruses exhibit a notably higher degree of virulence compared to clade 7.2 viruses. Our results contribute to the elucidation of the biological characterization and pathogenicity of HPAI H5N1 viruses.
Copyright ? 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.
PMID: 28245902 DOI: 10.3967/bes2017.009
[PubMed - in process] Free full text
[h=1]Characterization of Highly Pathogenic Avian Influenza H5N1 Viruses Isolated from Domestic Poultry in China.[/h] Lai CC[SUP]1[/SUP], Wang KY[SUP]1[/SUP], Chen R[SUP]2[/SUP], Zhang AJ[SUP]3[/SUP], Gu HJ[SUP]1[/SUP], Yin YB[SUP]4[/SUP], Wang DD[SUP]4[/SUP], Liu LL[SUP]4[/SUP], Xing L[SUP]1[/SUP], Tong YG[SUP]1[/SUP], Ma ZJ[SUP]3[/SUP], Yang PH[SUP]5[/SUP], Wang XL[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The highly pathogenic avian influenza (HPAI) H5N1 virus has caused several outbreaks in domestic poultry. Despite great efforts to control the spread of this virus, it continues to evolve and poses a substantial threat to public health because of a high mortality rate. In this study, we sequenced whole genomes of eight H5N1 avian influenza viruses isolated from domestic poultry in eastern China and compared them with those of typical influenza virus strains. Phylogenetic analyses showed that all eight genomes belonged to clade 2.3.2.1 and clade 7.2, the two main circulating clades in China. Viruses that clustered in clade 2.3.2.1 shared a high degree of homology with H5N1 isolates located in eastern Asian. Isolates that clustered in clade 7.2 were found to circulate throughout China, with an east-to-west density gradient. Pathogenicity studies in mice showed that these isolates replicate in the lungs, and clade 2.3.2.1 viruses exhibit a notably higher degree of virulence compared to clade 7.2 viruses. Our results contribute to the elucidation of the biological characterization and pathogenicity of HPAI H5N1 viruses.
Copyright ? 2017 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved.
PMID: 28245902 DOI: 10.3967/bes2017.009
[PubMed - in process] Free full text