tetano
Editor, Senior Moderator
Epidemiol Infect. 2019 Sep 25;147:e278. doi: 10.1017/S0950268819001407.
[h=1]Characteristics of hospitalised patients with influenza in 2015-2016 in northern Israel: three circulating strains and continued fear of 2009 A/H1N1.[/h] Kalish T[SUP]1[/SUP], Miron D[SUP]2,[/SUP][SUP]3[/SUP], Azrad M[SUP]4[/SUP], Rechnitzer H[SUP]5[/SUP], Ben-Amram H[SUP]6[/SUP], Glikman D[SUP]1,[/SUP][SUP]7[/SUP], Peretz A[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 The Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel. 2 Infectious Diseases Unit, Ziv Medical Center, Safed, Israel. 3 Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. 4 Clinical Microbiology Laboratory, Baruch Padeh Medical Center, Poriya, Israel. 5 Clinical Microbiology Laboratory, Galilee Medical Center, Nahariya, Israel. 6 Clinical Microbiology Laboratory, Ziv Medical Center, Safed, Israel. 7 Infectious Diseases Unit, Baruch Padeh Medical Center, Poriya, Israel.
[h=3]Abstract[/h] This study aimed to characterise children and adults diagnosed with influenza who were admitted to three medical centres in northern Israel in the winter of 2015-2016, a unique season due to infection with three types of influenza strains: A/H1N1, A/non-H1N1 and B. Data were collected retrospectively from medical records. Influenza A/H1N1 infected mainly adults (61% vs. 16% in children, P < 0.001) while influenza B was the common type in children (54% vs. 28% in adults, P < 0.001). Adults (36% vs. 5% in children, P < 0.001) and patients infected with A/H1N1 had higher rates of pneumonia (34% vs. 16% and 14% in influenza B and A/non-H1N1, respectively, P = 0.002). Treatment with oseltamivir was prescribed to 90% of patients; adults had higher rates of treatment (96% vs. 84% in children, P = 0.002) as well as patients infected with A/H1N1 (96% vs. 86% in influenza B and A/non-H1N1, respectively, P = 0.04). Oseltamivir was given after a mean of 3.6 days of symptoms. Preferential infection of adults by A/H1N1 was evident in Israel in 2015-2016; pneumonia rates were higher in adults and in A/H1N1-infected patients. Oseltamivir was prescribed to most patients but especially to those infected with A/H1N1, and was given relatively late in the course of the disease.
[h=4]KEYWORDS:[/h] Antiviral treatment; disease complications; influenza H1N1; influenza manifestations
PMID: 31551107 DOI: 10.1017/S0950268819001407
[h=1]Characteristics of hospitalised patients with influenza in 2015-2016 in northern Israel: three circulating strains and continued fear of 2009 A/H1N1.[/h] Kalish T[SUP]1[/SUP], Miron D[SUP]2,[/SUP][SUP]3[/SUP], Azrad M[SUP]4[/SUP], Rechnitzer H[SUP]5[/SUP], Ben-Amram H[SUP]6[/SUP], Glikman D[SUP]1,[/SUP][SUP]7[/SUP], Peretz A[SUP]1,[/SUP][SUP]4[/SUP].
[h=3]Author information[/h] 1 The Azrieli Faculty of Medicine, Bar Ilan University, Safed, Israel. 2 Infectious Diseases Unit, Ziv Medical Center, Safed, Israel. 3 Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. 4 Clinical Microbiology Laboratory, Baruch Padeh Medical Center, Poriya, Israel. 5 Clinical Microbiology Laboratory, Galilee Medical Center, Nahariya, Israel. 6 Clinical Microbiology Laboratory, Ziv Medical Center, Safed, Israel. 7 Infectious Diseases Unit, Baruch Padeh Medical Center, Poriya, Israel.
[h=3]Abstract[/h] This study aimed to characterise children and adults diagnosed with influenza who were admitted to three medical centres in northern Israel in the winter of 2015-2016, a unique season due to infection with three types of influenza strains: A/H1N1, A/non-H1N1 and B. Data were collected retrospectively from medical records. Influenza A/H1N1 infected mainly adults (61% vs. 16% in children, P < 0.001) while influenza B was the common type in children (54% vs. 28% in adults, P < 0.001). Adults (36% vs. 5% in children, P < 0.001) and patients infected with A/H1N1 had higher rates of pneumonia (34% vs. 16% and 14% in influenza B and A/non-H1N1, respectively, P = 0.002). Treatment with oseltamivir was prescribed to 90% of patients; adults had higher rates of treatment (96% vs. 84% in children, P = 0.002) as well as patients infected with A/H1N1 (96% vs. 86% in influenza B and A/non-H1N1, respectively, P = 0.04). Oseltamivir was given after a mean of 3.6 days of symptoms. Preferential infection of adults by A/H1N1 was evident in Israel in 2015-2016; pneumonia rates were higher in adults and in A/H1N1-infected patients. Oseltamivir was prescribed to most patients but especially to those infected with A/H1N1, and was given relatively late in the course of the disease.
[h=4]KEYWORDS:[/h] Antiviral treatment; disease complications; influenza H1N1; influenza manifestations
PMID: 31551107 DOI: 10.1017/S0950268819001407