tetano
Editor, Senior Moderator
Res Vet Sci. 2013 Jul 12. pii: S0034-5288(13)00212-9. doi: 10.1016/j.rvsc.2013.06.013. [Epub ahead of print]
Characterisation of one H6N6 influenza virus isolated from swine in China.
Zhao G, Chen C, Huang J, Wang Y, Peng D, Liu X.
Source
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China; Ministry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Abstract
There is multiple evidence that swine may act as a vessel for the generation of novel influenza A viruses. In this study, we have analyzed the evolution and pathogenicity of one strain of H6N6 influenza virus isolated from swine with clinical signs of infection in China. Although phylogenetic analysis revealed that this virus might originate from domestic ducks, pathogenicity experiments indicated that the virus replicated in mice without prior adaptation. These findings suggest that the virus has transmitted from ducks to swine in China, and replicated in mammalian hosts without prior adaptation, which may pose a threat to both veterinary and public health.
Copyright ? 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:
Evolution, H6N6, Influenza viruses, Phylogenetic analysis, Swine
PMID:
23856405
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23856405
Characterisation of one H6N6 influenza virus isolated from swine in China.
Zhao G, Chen C, Huang J, Wang Y, Peng D, Liu X.
Source
College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China; Ministry of Education Key Lab for Avian Preventive Medicine, Yangzhou University, Yangzhou, Jiangsu 225009, China.
Abstract
There is multiple evidence that swine may act as a vessel for the generation of novel influenza A viruses. In this study, we have analyzed the evolution and pathogenicity of one strain of H6N6 influenza virus isolated from swine with clinical signs of infection in China. Although phylogenetic analysis revealed that this virus might originate from domestic ducks, pathogenicity experiments indicated that the virus replicated in mice without prior adaptation. These findings suggest that the virus has transmitted from ducks to swine in China, and replicated in mammalian hosts without prior adaptation, which may pose a threat to both veterinary and public health.
Copyright ? 2013 Elsevier Ltd. All rights reserved.
KEYWORDS:
Evolution, H6N6, Influenza viruses, Phylogenetic analysis, Swine
PMID:
23856405
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23856405