tetano
Editor, Senior Moderator
J Virol. 2015 Dec 9. pii: JVI.02553-15. [Epub ahead of print]
[h=1]Changes in the length of the neuraminidase stalk region impacts H7N9 virulence in mice.[/h] Bi Y[SUP]1[/SUP], Xiao H[SUP]2[/SUP], Chen Q[SUP]3[/SUP], Wu Y[SUP]4[/SUP], Fu L[SUP]4[/SUP], Quan C[SUP]5[/SUP], Wong G[SUP]4[/SUP], Liu J[SUP]3[/SUP], Haywood J[SUP]4[/SUP], Liu Y[SUP]6[/SUP], Zhou B[SUP]6[/SUP], Yan J[SUP]4[/SUP], Liu W[SUP]7[/SUP], Gao GF[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The neuraminidase stalk of the newly-emerged H7N9 influenza virus possesses a five-amino acid deletion. This study focuses on characterizing the biological functions of H7N9 with varying neuraminidase stalk lengths. Results indicate that the five-amino acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19-20-amino acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 does.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26656694 [PubMed - as supplied by publisher]
[h=1]Changes in the length of the neuraminidase stalk region impacts H7N9 virulence in mice.[/h] Bi Y[SUP]1[/SUP], Xiao H[SUP]2[/SUP], Chen Q[SUP]3[/SUP], Wu Y[SUP]4[/SUP], Fu L[SUP]4[/SUP], Quan C[SUP]5[/SUP], Wong G[SUP]4[/SUP], Liu J[SUP]3[/SUP], Haywood J[SUP]4[/SUP], Liu Y[SUP]6[/SUP], Zhou B[SUP]6[/SUP], Yan J[SUP]4[/SUP], Liu W[SUP]7[/SUP], Gao GF[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The neuraminidase stalk of the newly-emerged H7N9 influenza virus possesses a five-amino acid deletion. This study focuses on characterizing the biological functions of H7N9 with varying neuraminidase stalk lengths. Results indicate that the five-amino acid deletion had no impact on virus infectivity or replication in vitro or in vivo compared to a full-length stalk, but enhanced virulence in mice was observed for H7N9 encoding a 19-20-amino acid deletion, suggesting that N9 stalk length impacts virulence in mammals, as N1 does.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.
PMID: 26656694 [PubMed - as supplied by publisher]