tetano
Editor, Senior Moderator
J Med Virol. 2019 Dec 30. doi: 10.1002/jmv.25660. [Epub ahead of print] [h=1]Changes in the etiology of viral lower respiratory tract infections in hospitalized children in Wenzhou, China: 2008-2017.[/h]
Wen S[SUP]1[/SUP], Yu M[SUP]1[/SUP], Zheng G[SUP]1[/SUP], Lv F[SUP]1[/SUP], Chen X[SUP]1[/SUP], Lin L[SUP]1[/SUP], Li C[SUP]1[/SUP], Zhang H[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Children's Respiratory Disease, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] This study investigated the seasonality and secular trends in the etiology of viral lower respiratory tract infections (LRTIs) among hospitalized children in Wenzhou, southeastern China.
[h=4]METHODS:[/h] A retrospective review was conducted concerning viral LRTIs in children hospitalized at a university hospital between January 1, 2008 and December 31, 2017. Direct immunofluorescence was used to detect respiratory syncytial virus (RSV), adenovirus (AdV), influenza A virus (Inf A), influenza B virus (Inf B), and human parainfluenza virus types 1-3 (hPIV1-3).
[h=4]RESULTS:[/h] Of 89,898 children tested, at least one viral respiratory pathogen was identified in 25.6% and multiple pathogens were identified in 0.4%. RSV (17.6%), hPIV3 (4.0%), and AdV (2.2%) were the most frequently detected pathogens. The proportion of positive samples varied with age and was the highest in children aged <6 months (36.2%). Seasonal differences were observed in RSV, AdV, Inf A, Inf B, hPIV1, and hPIV3 infections. There was a declining trend in the proportion of positive samples over time, primarily due to a decrease in RSV and hPIV3 infections.
[h=4]CONCLUSIONS:[/h] RSV, hPIV3, and AdV were the most common viral respiratory pathogens identified among hospitalized children with LRTIs. The distribution of viruses varied with age and season. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] adenovirus; human parainfluenza virus; influenza virus; respiratory syncytial virus
PMID: 31889316 DOI: 10.1002/jmv.25660
Wen S[SUP]1[/SUP], Yu M[SUP]1[/SUP], Zheng G[SUP]1[/SUP], Lv F[SUP]1[/SUP], Chen X[SUP]1[/SUP], Lin L[SUP]1[/SUP], Li C[SUP]1[/SUP], Zhang H[SUP]1[/SUP].
[h=3]Author information[/h] 1 Department of Children's Respiratory Disease, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, People's Republic of China.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] This study investigated the seasonality and secular trends in the etiology of viral lower respiratory tract infections (LRTIs) among hospitalized children in Wenzhou, southeastern China.
[h=4]METHODS:[/h] A retrospective review was conducted concerning viral LRTIs in children hospitalized at a university hospital between January 1, 2008 and December 31, 2017. Direct immunofluorescence was used to detect respiratory syncytial virus (RSV), adenovirus (AdV), influenza A virus (Inf A), influenza B virus (Inf B), and human parainfluenza virus types 1-3 (hPIV1-3).
[h=4]RESULTS:[/h] Of 89,898 children tested, at least one viral respiratory pathogen was identified in 25.6% and multiple pathogens were identified in 0.4%. RSV (17.6%), hPIV3 (4.0%), and AdV (2.2%) were the most frequently detected pathogens. The proportion of positive samples varied with age and was the highest in children aged <6 months (36.2%). Seasonal differences were observed in RSV, AdV, Inf A, Inf B, hPIV1, and hPIV3 infections. There was a declining trend in the proportion of positive samples over time, primarily due to a decrease in RSV and hPIV3 infections.
[h=4]CONCLUSIONS:[/h] RSV, hPIV3, and AdV were the most common viral respiratory pathogens identified among hospitalized children with LRTIs. The distribution of viruses varied with age and season. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] adenovirus; human parainfluenza virus; influenza virus; respiratory syncytial virus
PMID: 31889316 DOI: 10.1002/jmv.25660