tetano
Editor, Senior Moderator
Clin Microbiol Infect. 2011 Dec 8. doi: 10.1111/j.1469-0691.2011.03753.x. [Epub ahead of print]
Changes in epidemiology, clinical features and severity of influenza A (H1N1) 2009 pneumonia in the first post-pandemic influenza season.
Viasus D, Cordero E, Rodr?guez-Ba?o J, Oteo JA, Fern?ndez-Navarro A, Ortega L, Gracia-Ahufinger I, Fari?as MC, Garc?a-Almodovar E, Payeras A, Pa?o-Pardo JR, Mu?ez-Rubio E, Carratal? J; the Novel Influenza A (H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI).
Source
Hospital Universitari de Bellvitge - IDIBELL, University of Barcelona, Barcelona Hospital Universitario Virgen del Roc?o, Sevilla Hospital Universitario Virgen Macarena, Sevilla Hospital San Pedro - CIBIR, Logro?o SCIAS - Hospital de Barcelona, Barcelona Hospital Universitario Reina Sof?a - IMIBIC, University of C?rdoba, C?rdoba Hospital Universitario Marqu?s de Valdecilla, Santander Hospital Universitario Son Dureta - Son Espases, Palma de Mallorca Hospital Son Ll?tzer, Palma de Mallorca Hospital Universitario La Paz - IDIPAZ, Madrid Hospital Universitario Puerta de Hierro, Madrid, Spain.
Abstract
Clin Microbiol Infect ABSTRACT: Although the influenza A (H1N1) 2009 virus is expected to circulate as a seasonal virus for some years after the pandemic period, its behaviour cannot be predicted. We analysed a prospective cohort study of hospitalized adults with influenza A (H1N1) 2009 pneumonia at 14 teaching hospitals in Spain to compare the epidemiology, clinical features and outcomes of influenza A (H1N1) 2009 pneumonia between the pandemic period and the first post-pandemic influenza season. A total of 348 patients were included: 234 during the pandemic period and 114 during the first post-pandemic influenza season. Patients during the post-pandemic period were older and more likely to have chronic obstructive pulmonary disease, chronic kidney disease and cancer than the others. Septic shock, altered mental status and respiratory failure on arrival at hospital were significantly more common during the post-pandemic period. Time from illness onset to receipt of antiviral therapy was also longer during this period. Early antiviral therapy was less frequently administered to patients during the post-pandemic period (22.9% versus 10.9%; p 0.009). In addition, length of stay was longer, and need for mechanical ventilation and intensive-care unit admission were significantly higher during the post-pandemic period. In-hospital mortality (5.1% versus 21.2%; p <0.001) was also greater during this period. In conclusion, significant epidemiological changes and an increased severity of influenza A (H1N1) 2009 pneumonia were found in the first post-pandemic influenza season. Physicians should consider influenza A (H1N1) 2009 when selecting microbiological testing and treatment in patients with pneumonia in the upcoming influenza season.
? 2011 The Authors. Clinical Microbiology and Infection ? 2011 European Society of Clinical Microbiology and Infectious Diseases.
PMID:
22264321
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22264321
Changes in epidemiology, clinical features and severity of influenza A (H1N1) 2009 pneumonia in the first post-pandemic influenza season.
Viasus D, Cordero E, Rodr?guez-Ba?o J, Oteo JA, Fern?ndez-Navarro A, Ortega L, Gracia-Ahufinger I, Fari?as MC, Garc?a-Almodovar E, Payeras A, Pa?o-Pardo JR, Mu?ez-Rubio E, Carratal? J; the Novel Influenza A (H1N1) Study Group of the Spanish Network for Research in Infectious Diseases (REIPI).
Source
Hospital Universitari de Bellvitge - IDIBELL, University of Barcelona, Barcelona Hospital Universitario Virgen del Roc?o, Sevilla Hospital Universitario Virgen Macarena, Sevilla Hospital San Pedro - CIBIR, Logro?o SCIAS - Hospital de Barcelona, Barcelona Hospital Universitario Reina Sof?a - IMIBIC, University of C?rdoba, C?rdoba Hospital Universitario Marqu?s de Valdecilla, Santander Hospital Universitario Son Dureta - Son Espases, Palma de Mallorca Hospital Son Ll?tzer, Palma de Mallorca Hospital Universitario La Paz - IDIPAZ, Madrid Hospital Universitario Puerta de Hierro, Madrid, Spain.
Abstract
Clin Microbiol Infect ABSTRACT: Although the influenza A (H1N1) 2009 virus is expected to circulate as a seasonal virus for some years after the pandemic period, its behaviour cannot be predicted. We analysed a prospective cohort study of hospitalized adults with influenza A (H1N1) 2009 pneumonia at 14 teaching hospitals in Spain to compare the epidemiology, clinical features and outcomes of influenza A (H1N1) 2009 pneumonia between the pandemic period and the first post-pandemic influenza season. A total of 348 patients were included: 234 during the pandemic period and 114 during the first post-pandemic influenza season. Patients during the post-pandemic period were older and more likely to have chronic obstructive pulmonary disease, chronic kidney disease and cancer than the others. Septic shock, altered mental status and respiratory failure on arrival at hospital were significantly more common during the post-pandemic period. Time from illness onset to receipt of antiviral therapy was also longer during this period. Early antiviral therapy was less frequently administered to patients during the post-pandemic period (22.9% versus 10.9%; p 0.009). In addition, length of stay was longer, and need for mechanical ventilation and intensive-care unit admission were significantly higher during the post-pandemic period. In-hospital mortality (5.1% versus 21.2%; p <0.001) was also greater during this period. In conclusion, significant epidemiological changes and an increased severity of influenza A (H1N1) 2009 pneumonia were found in the first post-pandemic influenza season. Physicians should consider influenza A (H1N1) 2009 when selecting microbiological testing and treatment in patients with pneumonia in the upcoming influenza season.
? 2011 The Authors. Clinical Microbiology and Infection ? 2011 European Society of Clinical Microbiology and Infectious Diseases.
PMID:
22264321
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22264321