tetano
Editor, Senior Moderator
Vaccine. 2016 Apr 4. pii: S0264-410X(16)30088-3. doi: 10.1016/j.vaccine.2016.03.091. [Epub ahead of print]
[h=1]Cellular and humoral influenza-specific immune response upon vaccination in patients with common variable immunodeficiency and unclassified antibody deficiency.[/h] Hanitsch LG[SUP]1[/SUP], L?bel M[SUP]2[/SUP], Mieves JF[SUP]2[/SUP], Bauer S[SUP]2[/SUP], Babel N[SUP]3[/SUP], Schweiger B[SUP]4[/SUP], Wittke K[SUP]2[/SUP], Grabowski P[SUP]2[/SUP], Volk HD[SUP]5[/SUP], Scheibenbogen C[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immunization against seasonal influenza with inactivated vaccine is recommended for patients with common variable immunodeficiency (CVID). However, humoral vaccine response in CVID patients is frequently impaired and current knowledge on T cell vaccine response in CVID and other patients with antibody deficiency is poor.
[h=4]OBJECTIVE:[/h] In the present study, we comparatively analyzed the antibody and T cellular immune response of patients with CVID and unclassified antibody deficiency to influenza vaccination in the season 2013/2014.
[h=4]METHODS:[/h] Eight patients with CVID, 8 patients with unclassified antibody deficiency and 9 healthy controls were vaccinated with a single dose of non-adjuvanted seasonal influenza vaccine. Before and 3 weeks after the vaccination antibody titers against the strains A/California/7/2009, A/Texas/50/2012, and B/Massachusetts/02/2012 included in the vaccine were measured by hemagglutination inhibition testing. Additionally, vaccine-specific T cell cytokine response was determined by stimulation with the complete vaccine in vitro.
[h=4]RESULTS:[/h] Whereas all healthy controls responded to vaccination with serum antibody titers, only 1/8 CVID patients and 4/8 patients with unclassified antibody deficiency showed a response against at least 1 of the 3 vaccine strains. However, 7/8 of the CVID and 6/8 of the patients with unclassified antibody deficiency had similar frequencies of vaccine-induced IFN-γ, TNF-α and IL-2 producing CD40L[SUP]+[/SUP] T cells as the control group.
[h=4]CONCLUSION:[/h] Our data suggest that most CVID and unclassified antibody deficiency patients benefit from seasonal influenza vaccination by mounting a cellular response.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] CVID; Cytokines; Influenza vaccination; T cell response; Unclassified antibody deficiency
PMID: 27055021 [PubMed - as supplied by publisher]
[h=1]Cellular and humoral influenza-specific immune response upon vaccination in patients with common variable immunodeficiency and unclassified antibody deficiency.[/h] Hanitsch LG[SUP]1[/SUP], L?bel M[SUP]2[/SUP], Mieves JF[SUP]2[/SUP], Bauer S[SUP]2[/SUP], Babel N[SUP]3[/SUP], Schweiger B[SUP]4[/SUP], Wittke K[SUP]2[/SUP], Grabowski P[SUP]2[/SUP], Volk HD[SUP]5[/SUP], Scheibenbogen C[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immunization against seasonal influenza with inactivated vaccine is recommended for patients with common variable immunodeficiency (CVID). However, humoral vaccine response in CVID patients is frequently impaired and current knowledge on T cell vaccine response in CVID and other patients with antibody deficiency is poor.
[h=4]OBJECTIVE:[/h] In the present study, we comparatively analyzed the antibody and T cellular immune response of patients with CVID and unclassified antibody deficiency to influenza vaccination in the season 2013/2014.
[h=4]METHODS:[/h] Eight patients with CVID, 8 patients with unclassified antibody deficiency and 9 healthy controls were vaccinated with a single dose of non-adjuvanted seasonal influenza vaccine. Before and 3 weeks after the vaccination antibody titers against the strains A/California/7/2009, A/Texas/50/2012, and B/Massachusetts/02/2012 included in the vaccine were measured by hemagglutination inhibition testing. Additionally, vaccine-specific T cell cytokine response was determined by stimulation with the complete vaccine in vitro.
[h=4]RESULTS:[/h] Whereas all healthy controls responded to vaccination with serum antibody titers, only 1/8 CVID patients and 4/8 patients with unclassified antibody deficiency showed a response against at least 1 of the 3 vaccine strains. However, 7/8 of the CVID and 6/8 of the patients with unclassified antibody deficiency had similar frequencies of vaccine-induced IFN-γ, TNF-α and IL-2 producing CD40L[SUP]+[/SUP] T cells as the control group.
[h=4]CONCLUSION:[/h] Our data suggest that most CVID and unclassified antibody deficiency patients benefit from seasonal influenza vaccination by mounting a cellular response.
Copyright ? 2016. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] CVID; Cytokines; Influenza vaccination; T cell response; Unclassified antibody deficiency
PMID: 27055021 [PubMed - as supplied by publisher]