tetano
Editor, Senior Moderator
Cells
. 2021 Jun 6;10(6):1412.
doi: 10.3390/cells10061412.
Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome
Chong-Hyun Shin[SUP] 1 [/SUP], Ki-Hye Kim[SUP] 1 [/SUP], Subbiah Jeeva[SUP] 1 [/SUP], Sang-Moo Kang[SUP] 1 [/SUP]
Affiliations
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to the coronavirus disease 2019 (COVID-19) pandemic. A strong correlation has been demonstrated between worse COVID-19 outcomes, aging, and metabolic syndrome (MetS), which is primarily derived from obesity-induced systemic chronic low-grade inflammation with numerous complications, including type 2 diabetes mellitus (T2DM). The majority of COVID-19 deaths occurs in people over the age of 65. Individuals with MetS are inclined to manifest adverse disease consequences and mortality from COVID-19. In this review, we examine the prevalence and molecular mechanisms underlying enhanced risk of COVID-19 in elderly people and individuals with MetS. Subsequently, we discuss current progresses in treating COVID-19, including the development of new COVID-19 vaccines and antivirals, towards goals to elaborate prophylactic and therapeutic treatment options in this vulnerable population.
Keywords: COVID-19; SARS-CoV-2; aging; diabetes; metabolic syndrome; obesity; therapeutic drugs; vaccines.
. 2021 Jun 6;10(6):1412.
doi: 10.3390/cells10061412.
Towards Goals to Refine Prophylactic and Therapeutic Strategies Against COVID-19 Linked to Aging and Metabolic Syndrome
Chong-Hyun Shin[SUP] 1 [/SUP], Ki-Hye Kim[SUP] 1 [/SUP], Subbiah Jeeva[SUP] 1 [/SUP], Sang-Moo Kang[SUP] 1 [/SUP]
Affiliations
- PMID: 34204163
- DOI: 10.3390/cells10061412
Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to the coronavirus disease 2019 (COVID-19) pandemic. A strong correlation has been demonstrated between worse COVID-19 outcomes, aging, and metabolic syndrome (MetS), which is primarily derived from obesity-induced systemic chronic low-grade inflammation with numerous complications, including type 2 diabetes mellitus (T2DM). The majority of COVID-19 deaths occurs in people over the age of 65. Individuals with MetS are inclined to manifest adverse disease consequences and mortality from COVID-19. In this review, we examine the prevalence and molecular mechanisms underlying enhanced risk of COVID-19 in elderly people and individuals with MetS. Subsequently, we discuss current progresses in treating COVID-19, including the development of new COVID-19 vaccines and antivirals, towards goals to elaborate prophylactic and therapeutic treatment options in this vulnerable population.
Keywords: COVID-19; SARS-CoV-2; aging; diabetes; metabolic syndrome; obesity; therapeutic drugs; vaccines.