tetano
Editor, Senior Moderator
Cells
. 2021 May 7;10(5):1130.
doi: 10.3390/cells10051130.
The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection
Antonella D'Amore[SUP] 1 [/SUP], Antonella Gradogna[SUP] 2 [/SUP], Fioretta Palombi[SUP] 1 [/SUP], Velia Minicozzi[SUP] 3 [/SUP], Matteo Ceccarelli[SUP] 4 5 [/SUP], Armando Carpaneto[SUP] 2 6 [/SUP], Antonio Filippini[SUP] 1 [/SUP]
Affiliations
Abstract
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19.
Keywords: SARS-CoV-2; TPC channels; coronavirus; flavonoids; mammalian endolysosome; plant vacuole.
. 2021 May 7;10(5):1130.
doi: 10.3390/cells10051130.
The Discovery of Naringenin as Endolysosomal Two-Pore Channel Inhibitor and Its Emerging Role in SARS-CoV-2 Infection
Antonella D'Amore[SUP] 1 [/SUP], Antonella Gradogna[SUP] 2 [/SUP], Fioretta Palombi[SUP] 1 [/SUP], Velia Minicozzi[SUP] 3 [/SUP], Matteo Ceccarelli[SUP] 4 5 [/SUP], Armando Carpaneto[SUP] 2 6 [/SUP], Antonio Filippini[SUP] 1 [/SUP]
Affiliations
- PMID: 34067054
- DOI: 10.3390/cells10051130
Abstract
The flavonoid naringenin (Nar), present in citrus fruits and tomatoes, has been identified as a blocker of an emerging class of human intracellular channels, namely the two-pore channel (TPC) family, whose role has been established in several diseases. Indeed, Nar was shown to be effective against neoangiogenesis, a process essential for solid tumor progression, by specifically impairing TPC activity. The goal of the present review is to illustrate the rationale that links TPC channels to the mechanism of coronavirus infection, and how their inhibition by Nar could be an efficient pharmacological strategy to fight the current pandemic plague COVID-19.
Keywords: SARS-CoV-2; TPC channels; coronavirus; flavonoids; mammalian endolysosome; plant vacuole.