tetano
Editor, Senior Moderator
Cell
. 2022 Feb 16;S0092-8674(22)00194-5.
doi: 10.1016/j.cell.2022.02.014. Online ahead of print.
Virome characterization of game animals in China reveals a spectrum of emerging pathogens
Wan-Ting He[SUP] 1 [/SUP], Xin Hou[SUP] 2 [/SUP], Jin Zhao[SUP] 1 [/SUP], Jiumeng Sun[SUP] 1 [/SUP], Haijian He[SUP] 3 [/SUP], Wei Si[SUP] 4 [/SUP], Jing Wang[SUP] 2 [/SUP], Zhiwen Jiang[SUP] 1 [/SUP], Ziqing Yan[SUP] 1 [/SUP], Gang Xing[SUP] 4 [/SUP], Meng Lu[SUP] 1 [/SUP], Marc A Suchard[SUP] 5 [/SUP], Xiang Ji[SUP] 6 [/SUP], Wenjie Gong[SUP] 7 [/SUP], Biao He[SUP] 7 [/SUP], Jun Li[SUP] 8 [/SUP], Philippe Lemey[SUP] 9 [/SUP], Deyin Guo[SUP] 2 [/SUP], Changchun Tu[SUP] 7 [/SUP], Edward C Holmes[SUP] 10 [/SUP], Mang Shi[SUP] 11 [/SUP], Shuo Su[SUP] 12 [/SUP]
Affiliations
Abstract
Game animals are wildlife species traded and consumed as food and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1,941 game animals, representing 18 species and five mammalian orders, sampled across China. From this, we identified 102 mammalian-infecting viruses, with 65 described for the first time. Twenty-one viruses were considered as potentially high risk to humans and domestic animals. Civets (Paguma larvata) carried the highest number of potentially high-risk viruses. We inferred the transmission of Bat coronavirus from bats to civets, as well as cross-species jumps of coronaviruses from bats to hedgehogs, from birds to porcupines, and from dogs to raccoon dogs. Of note, we identified avian Influenza A virus H9N2 in civets and Asian badgers, with the latter displaying respiratory symptoms, as well as cases of likely human-to-wildlife virus transmission. These data highlight the importance of game animals as potential drivers of disease emergence.
Keywords: coronavirus; disease emergence; emerging pathogens; evolution; game animals; host switch; virome.
. 2022 Feb 16;S0092-8674(22)00194-5.
doi: 10.1016/j.cell.2022.02.014. Online ahead of print.
Virome characterization of game animals in China reveals a spectrum of emerging pathogens
Wan-Ting He[SUP] 1 [/SUP], Xin Hou[SUP] 2 [/SUP], Jin Zhao[SUP] 1 [/SUP], Jiumeng Sun[SUP] 1 [/SUP], Haijian He[SUP] 3 [/SUP], Wei Si[SUP] 4 [/SUP], Jing Wang[SUP] 2 [/SUP], Zhiwen Jiang[SUP] 1 [/SUP], Ziqing Yan[SUP] 1 [/SUP], Gang Xing[SUP] 4 [/SUP], Meng Lu[SUP] 1 [/SUP], Marc A Suchard[SUP] 5 [/SUP], Xiang Ji[SUP] 6 [/SUP], Wenjie Gong[SUP] 7 [/SUP], Biao He[SUP] 7 [/SUP], Jun Li[SUP] 8 [/SUP], Philippe Lemey[SUP] 9 [/SUP], Deyin Guo[SUP] 2 [/SUP], Changchun Tu[SUP] 7 [/SUP], Edward C Holmes[SUP] 10 [/SUP], Mang Shi[SUP] 11 [/SUP], Shuo Su[SUP] 12 [/SUP]
Affiliations
- PMID: 35298912
- DOI: 10.1016/j.cell.2022.02.014
Abstract
Game animals are wildlife species traded and consumed as food and are potential reservoirs for SARS-CoV and SARS-CoV-2. We performed a meta-transcriptomic analysis of 1,941 game animals, representing 18 species and five mammalian orders, sampled across China. From this, we identified 102 mammalian-infecting viruses, with 65 described for the first time. Twenty-one viruses were considered as potentially high risk to humans and domestic animals. Civets (Paguma larvata) carried the highest number of potentially high-risk viruses. We inferred the transmission of Bat coronavirus from bats to civets, as well as cross-species jumps of coronaviruses from bats to hedgehogs, from birds to porcupines, and from dogs to raccoon dogs. Of note, we identified avian Influenza A virus H9N2 in civets and Asian badgers, with the latter displaying respiratory symptoms, as well as cases of likely human-to-wildlife virus transmission. These data highlight the importance of game animals as potential drivers of disease emergence.
Keywords: coronavirus; disease emergence; emerging pathogens; evolution; game animals; host switch; virome.