tetano
Editor, Senior Moderator
Cell Stress Chaperones
. 2023 Oct 5.
doi: 10.1007/s12192-023-01379-0. Online ahead of print. SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway
Rabab S Hamad[SUP] #[/SUP][SUP] 1 2 [/SUP], Hayder M Al-Kuraishy[SUP] #[/SUP][SUP] 3 [/SUP], Athanasios Alexiou[SUP] 4 5 [/SUP], Marios Papadakis[SUP] 6 [/SUP], Eman A Ahmed[SUP] 7 [/SUP], Hebatallah M Saad[SUP] 8 [/SUP], Gaber El-Saber Batiha[SUP] 9 [/SUP]
Affiliations
Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and extra-pulmonary manifestations due to the development of oxidative stress (OS) and hyperinflammation. The underlying cause for OS and hyperinflammation in COVID-19 may be related to the inhibition of nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidative responses and cellular homeostasis. The Nrf2 pathway inhibits the expression of pro-inflammatory cytokines and the development of cytokine storm and OS in COVID-19. Nrf2 activators can attenuate endothelial dysfunction (ED), renin-angiotensin system (RAS) dysregulation, immune thrombosis, and coagulopathy. Hence, this review aimed to reveal the potential role of the Nrf2 pathway and its activators in the management of COVID-19. As well, we tried to revise the mechanistic role of the Nrf2 pathway in COVID-19.
Keywords: COVID-19; Nuclear factor erythroid 2-related factor 2; Oxidative stress; SARS-CoV-2.
. 2023 Oct 5.
doi: 10.1007/s12192-023-01379-0. Online ahead of print. SARS-CoV-2 infection and dysregulation of nuclear factor erythroid-2-related factor 2 (Nrf2) pathway
Rabab S Hamad[SUP] #[/SUP][SUP] 1 2 [/SUP], Hayder M Al-Kuraishy[SUP] #[/SUP][SUP] 3 [/SUP], Athanasios Alexiou[SUP] 4 5 [/SUP], Marios Papadakis[SUP] 6 [/SUP], Eman A Ahmed[SUP] 7 [/SUP], Hebatallah M Saad[SUP] 8 [/SUP], Gaber El-Saber Batiha[SUP] 9 [/SUP]
Affiliations
- PMID: 37796433
- DOI: 10.1007/s12192-023-01379-0
Coronavirus disease 2019 (COVID-19) is a recent pandemic caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) leading to pulmonary and extra-pulmonary manifestations due to the development of oxidative stress (OS) and hyperinflammation. The underlying cause for OS and hyperinflammation in COVID-19 may be related to the inhibition of nuclear factor erythroid 2-related factor 2 (Nrf2), a master regulator of antioxidative responses and cellular homeostasis. The Nrf2 pathway inhibits the expression of pro-inflammatory cytokines and the development of cytokine storm and OS in COVID-19. Nrf2 activators can attenuate endothelial dysfunction (ED), renin-angiotensin system (RAS) dysregulation, immune thrombosis, and coagulopathy. Hence, this review aimed to reveal the potential role of the Nrf2 pathway and its activators in the management of COVID-19. As well, we tried to revise the mechanistic role of the Nrf2 pathway in COVID-19.
Keywords: COVID-19; Nuclear factor erythroid 2-related factor 2; Oxidative stress; SARS-CoV-2.