tetano
Editor, Senior Moderator
[h=1]Western Zika Virus in Human Fetal Neural Progenitors Persists Long Term with Partial Cytopathic and Limited Immunogenic Effects[/h] Natasha W. Hanners
, Jennifer L. Eitson
, Noriyoshi Usui
, R. Blake Richardson
, Eric M. Wexler
, Genevieve Konopka
, John W. Schoggins
Publication stage: In Press Corrected Proof
Open Access
DOI: http://dx.doi.org/10.1016/j.celrep.2016.05.075
[h=2]Introduction[/h] Zika virus (ZIKV) is a positive-sense, single-stranded RNA virus in the Flaviviridae family. In 2015, the detection of circulating ZIKV in Brazil later coincided with an alarming increase in the number of babies born with microcephaly (Kindhauser et al., 2016, Schuler-Faccini et al., 2016). Accumulating evidence has now been deemed sufficiently strong to establish a causal relationship between maternal ZIKV infection and microcephaly and other fetal brain anomalies (Rasmussen et al., 2016). In adults, 93% of patients diagnosed with Guillain-Barr? syndrome during the French Polynesia outbreak of 2013 were positive for ZIKV IgM (Cao-Lormeau et al., 2016). These findings indicate that contemporary ZIKV is highly neurovirulent, with particularly devastating consequences in fetuses.
full article
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30688-X
, Jennifer L. Eitson
, Noriyoshi Usui
, R. Blake Richardson
, Eric M. Wexler
, Genevieve Konopka
, John W. Schoggins
Publication stage: In Press Corrected Proof
Open Access
DOI: http://dx.doi.org/10.1016/j.celrep.2016.05.075
[h=2]Introduction[/h] Zika virus (ZIKV) is a positive-sense, single-stranded RNA virus in the Flaviviridae family. In 2015, the detection of circulating ZIKV in Brazil later coincided with an alarming increase in the number of babies born with microcephaly (Kindhauser et al., 2016, Schuler-Faccini et al., 2016). Accumulating evidence has now been deemed sufficiently strong to establish a causal relationship between maternal ZIKV infection and microcephaly and other fetal brain anomalies (Rasmussen et al., 2016). In adults, 93% of patients diagnosed with Guillain-Barr? syndrome during the French Polynesia outbreak of 2013 were positive for ZIKV IgM (Cao-Lormeau et al., 2016). These findings indicate that contemporary ZIKV is highly neurovirulent, with particularly devastating consequences in fetuses.
full article
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30688-X