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Editor, Senior Moderator
[h=1]The IFITMs Inhibit Zika Virus Replication[/h] George Savidis
, Jill M. Perreira
, Jocelyn M. Portmann
, Paul Meraner
, Zhiru Guo
, Sharone Green
, Abraham L. Brass
Publication stage: In Press Corrected Proof
Open Access
DOI: http://dx.doi.org/10.1016/j.celrep.2016.05.074
Zika virus has emerged as a severe health threat by virtue of its fast paced global spread and its associated morbidities, including microcephaly and Guillain-Barre syndrome (D?Ortenzio et al., 2016, Driggers et al., 2016, Haug et al., 2016, Lazear and Diamond, 2016, Musso and Gubler, 2016, Rasmussen et al., 2016). Zika virus was initially isolated from an infected macaque in Uganda in 1947, and the first human cases were reported in 1952. Similar to the closely related dengue virus, Zika virus is primarily spread via the bite of an infected Aedes mosquito. In 2007, Zika virus emerged in Micronesia and expanded its range to Southeast Asia. Zika virus was identified in Brazil in May 2015 and has since led to widespread infection in Central and South America.
Zika virus illness has been described as self-limited and moderate in severity with the common findings of malaise, headache, fever, joint aches, a maculopapular rash, and inflammation of the conjunctiva (Haug et al., 2016, Lazear and Diamond, 2016). However, an alarming number of birth defects, including microcephaly, have been attributed to Zika virus infection occurring in the first two trimesters of pregnancy (Driggers et al., 2016, Haug et al., 2016, Rasmussen et al., 2016). In addition, an upsurge in reported cases of Guillain-Barre syndrome, which manifests as a symmetric ascending flaccid paralysis, have recently been associated with Zika virus infection. Multiple reports have demonstrated that Zika virus can be sexually transmitted via infected seminal fluid, with resultant infection of pregnant mothers; the risk of sexual transmission may persist for months after remission of clinical illness (D?Ortenzio et al., 2016). These events have led to Zika virus being declared a public health emergency by the World Health Organization.
full article
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30687-8
, Jill M. Perreira
, Jocelyn M. Portmann
, Paul Meraner
, Zhiru Guo
, Sharone Green
, Abraham L. Brass
Publication stage: In Press Corrected Proof
Open Access
DOI: http://dx.doi.org/10.1016/j.celrep.2016.05.074
Zika virus has emerged as a severe health threat by virtue of its fast paced global spread and its associated morbidities, including microcephaly and Guillain-Barre syndrome (D?Ortenzio et al., 2016, Driggers et al., 2016, Haug et al., 2016, Lazear and Diamond, 2016, Musso and Gubler, 2016, Rasmussen et al., 2016). Zika virus was initially isolated from an infected macaque in Uganda in 1947, and the first human cases were reported in 1952. Similar to the closely related dengue virus, Zika virus is primarily spread via the bite of an infected Aedes mosquito. In 2007, Zika virus emerged in Micronesia and expanded its range to Southeast Asia. Zika virus was identified in Brazil in May 2015 and has since led to widespread infection in Central and South America.
Zika virus illness has been described as self-limited and moderate in severity with the common findings of malaise, headache, fever, joint aches, a maculopapular rash, and inflammation of the conjunctiva (Haug et al., 2016, Lazear and Diamond, 2016). However, an alarming number of birth defects, including microcephaly, have been attributed to Zika virus infection occurring in the first two trimesters of pregnancy (Driggers et al., 2016, Haug et al., 2016, Rasmussen et al., 2016). In addition, an upsurge in reported cases of Guillain-Barre syndrome, which manifests as a symmetric ascending flaccid paralysis, have recently been associated with Zika virus infection. Multiple reports have demonstrated that Zika virus can be sexually transmitted via infected seminal fluid, with resultant infection of pregnant mothers; the risk of sexual transmission may persist for months after remission of clinical illness (D?Ortenzio et al., 2016). These events have led to Zika virus being declared a public health emergency by the World Health Organization.
full article
http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30687-8