tetano
Editor, Senior Moderator
Cell Rep Med
. 2022 Jun 20;100679.
doi: 10.1016/j.xcrm.2022.100679. Online ahead of print.
Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant
Kirsten E Lyke[SUP] 1 [/SUP], Robert L Atmar[SUP] 2 [/SUP], Clara Dominguez Islas[SUP] 3 [/SUP], Christine M Posavad[SUP] 4 [/SUP], Daniel Szydlo[SUP] 5 [/SUP], Rahul Paul Chourdhury[SUP] 5 [/SUP], Meagan E Deming[SUP] 6 [/SUP], Amanda Eaton[SUP] 7 [/SUP], Lisa A Jackson[SUP] 8 [/SUP], Angela R Branche[SUP] 9 [/SUP], Hana M El Sahly[SUP] 10 [/SUP], Christina A Rostad[SUP] 11 [/SUP], Judith M Martin[SUP] 12 [/SUP], Christine Johnston[SUP] 13 [/SUP], Richard E Rupp[SUP] 14 [/SUP], Mark J Mulligan[SUP] 15 [/SUP], Rebecca C Brady[SUP] 16 [/SUP], Robert W Frenck Jr[SUP] 16 [/SUP], Martín Bäcker[SUP] 17 [/SUP], Angelica C Kottkamp[SUP] 15 [/SUP], Tara M Babu[SUP] 18 [/SUP], Kumaravel Rajakumar[SUP] 12 [/SUP], Srilatha Edupuganti[SUP] 19 [/SUP], David Dobrzynski[SUP] 9 [/SUP], Rhea N Coler[SUP] 20 [/SUP], Janet I Archer[SUP] 21 [/SUP], Sonja Crandon[SUP] 22 [/SUP], Jillian A Zemanek[SUP] 5 [/SUP], Elizabeth R Brown[SUP] 3 [/SUP], Kathleen M Neuzil[SUP] 6 [/SUP], David S Stephens[SUP] 23 [/SUP], Diane J Post[SUP] 22 [/SUP], Seema U Nayak[SUP] 22 [/SUP], Mehul S Suthar[SUP] 24 [/SUP], Paul C Roberts[SUP] 22 [/SUP], John H Beigel[SUP] 22 [/SUP], David C Montefiori[SUP] 25 [/SUP], DMID 21-0012 Study Group
Collaborators, Affiliations
Abstract
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost to generate protective immunity. We assess the magnitude and short-term durability of neutralizing antibodies after homologous and heterologous boosting with mRNA and Ad26.COV2.S vaccines. All prime-boost combinations substantially increase the neutralization titers to Omicron, although the boosted titers decline rapidly within 2 months from the peak response compared with boosted titers against the prototypic D614G variant. Boosted Omicron neutralization titers are substantially higher for homologous mRNA vaccine boosting, and for heterologous mRNA and Ad26.COV2.S vaccine boosting, compared with homologous Ad26.COV2.S boosting. Homologous mRNA vaccine boosting generates nearly equivalent neutralizing activity against Omicron sublineages BA.1, BA.2, and BA.3 but modestly reduced neutralizing activity against BA.2.12.1 and BA.4/BA.5 compared with BA.1. These results have implications for boosting requirements to protect against Omicron and future variants of SARS-CoV-2. This trial was conducted under ClincalTrials.gov: NCT04889209.
Keywords: BA.2.12.1; BA.4/BA.5; COVID-19; Omicron variant; SARS-CoV-2; booster; mRNA vaccine; neutralizing antibody; recombinant adenovirus vaccine; sublineage.
. 2022 Jun 20;100679.
doi: 10.1016/j.xcrm.2022.100679. Online ahead of print.
Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant
Kirsten E Lyke[SUP] 1 [/SUP], Robert L Atmar[SUP] 2 [/SUP], Clara Dominguez Islas[SUP] 3 [/SUP], Christine M Posavad[SUP] 4 [/SUP], Daniel Szydlo[SUP] 5 [/SUP], Rahul Paul Chourdhury[SUP] 5 [/SUP], Meagan E Deming[SUP] 6 [/SUP], Amanda Eaton[SUP] 7 [/SUP], Lisa A Jackson[SUP] 8 [/SUP], Angela R Branche[SUP] 9 [/SUP], Hana M El Sahly[SUP] 10 [/SUP], Christina A Rostad[SUP] 11 [/SUP], Judith M Martin[SUP] 12 [/SUP], Christine Johnston[SUP] 13 [/SUP], Richard E Rupp[SUP] 14 [/SUP], Mark J Mulligan[SUP] 15 [/SUP], Rebecca C Brady[SUP] 16 [/SUP], Robert W Frenck Jr[SUP] 16 [/SUP], Martín Bäcker[SUP] 17 [/SUP], Angelica C Kottkamp[SUP] 15 [/SUP], Tara M Babu[SUP] 18 [/SUP], Kumaravel Rajakumar[SUP] 12 [/SUP], Srilatha Edupuganti[SUP] 19 [/SUP], David Dobrzynski[SUP] 9 [/SUP], Rhea N Coler[SUP] 20 [/SUP], Janet I Archer[SUP] 21 [/SUP], Sonja Crandon[SUP] 22 [/SUP], Jillian A Zemanek[SUP] 5 [/SUP], Elizabeth R Brown[SUP] 3 [/SUP], Kathleen M Neuzil[SUP] 6 [/SUP], David S Stephens[SUP] 23 [/SUP], Diane J Post[SUP] 22 [/SUP], Seema U Nayak[SUP] 22 [/SUP], Mehul S Suthar[SUP] 24 [/SUP], Paul C Roberts[SUP] 22 [/SUP], John H Beigel[SUP] 22 [/SUP], David C Montefiori[SUP] 25 [/SUP], DMID 21-0012 Study Group
Collaborators, Affiliations
- PMID: 35798000
- DOI: 10.1016/j.xcrm.2022.100679
Abstract
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost to generate protective immunity. We assess the magnitude and short-term durability of neutralizing antibodies after homologous and heterologous boosting with mRNA and Ad26.COV2.S vaccines. All prime-boost combinations substantially increase the neutralization titers to Omicron, although the boosted titers decline rapidly within 2 months from the peak response compared with boosted titers against the prototypic D614G variant. Boosted Omicron neutralization titers are substantially higher for homologous mRNA vaccine boosting, and for heterologous mRNA and Ad26.COV2.S vaccine boosting, compared with homologous Ad26.COV2.S boosting. Homologous mRNA vaccine boosting generates nearly equivalent neutralizing activity against Omicron sublineages BA.1, BA.2, and BA.3 but modestly reduced neutralizing activity against BA.2.12.1 and BA.4/BA.5 compared with BA.1. These results have implications for boosting requirements to protect against Omicron and future variants of SARS-CoV-2. This trial was conducted under ClincalTrials.gov: NCT04889209.
Keywords: BA.2.12.1; BA.4/BA.5; COVID-19; Omicron variant; SARS-CoV-2; booster; mRNA vaccine; neutralizing antibody; recombinant adenovirus vaccine; sublineage.