tetano
Editor, Senior Moderator
Cell Rep Med
. 2022 Oct 6;100793.
doi: 10.1016/j.xcrm.2022.100793. Online ahead of print.
A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines
Joey Ming Er Lim[SUP] 1 [/SUP], Shou Kit Hang[SUP] 1 [/SUP], Smrithi Hariharaputran[SUP] 1 [/SUP], Adeline Chia[SUP] 1 [/SUP], Nicole Tan[SUP] 1 [/SUP], Eng Sing Lee[SUP] 2 [/SUP], Edwin Chng[SUP] 3 [/SUP], Poh Lian Lim[SUP] 4 [/SUP], Barnaby E Young[SUP] 4 [/SUP], David Chien Lye[SUP] 5 [/SUP], Nina Le Bert[SUP] 1 [/SUP], Antonio Bertoletti[SUP] 6 [/SUP], Anthony T Tan[SUP] 7 [/SUP]
Affiliations
Abstract
Unlike mRNA vaccines based only on the spike protein, inactivated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines should induce a diversified T cell response recognizing distinct structural proteins. Here, we perform a comparative analysis of SARS-CoV-2-specific T cells in healthy individuals following vaccination with inactivated SARS-CoV-2 or mRNA vaccines. Relative to spike mRNA vaccination, inactivated vaccines elicit a lower magnitude of spike-specific T cells, but the combination of membrane, nucleoprotein, and spike-specific T cell response is quantitatively comparable with the sole spike T cell response induced by mRNA vaccine, and they efficiently tolerate the mutations characterizing the Omicron lineage. However, this multi-protein-specific T cell response is not mediated by a coordinated CD4 and CD8 T cell expansion but by selective priming of CD4 T cells. These findings can help in understanding the role of CD4 and CD8 T cells in the efficacy of the different vaccines to control severe COVID-19 after Omicron infection.
Keywords: COVID-19; T cell response; adaptive immune response; inactivated vaccine.
. 2022 Oct 6;100793.
doi: 10.1016/j.xcrm.2022.100793. Online ahead of print.
A comparative characterization of SARS-CoV-2-specific T cells induced by mRNA or inactive virus COVID-19 vaccines
Joey Ming Er Lim[SUP] 1 [/SUP], Shou Kit Hang[SUP] 1 [/SUP], Smrithi Hariharaputran[SUP] 1 [/SUP], Adeline Chia[SUP] 1 [/SUP], Nicole Tan[SUP] 1 [/SUP], Eng Sing Lee[SUP] 2 [/SUP], Edwin Chng[SUP] 3 [/SUP], Poh Lian Lim[SUP] 4 [/SUP], Barnaby E Young[SUP] 4 [/SUP], David Chien Lye[SUP] 5 [/SUP], Nina Le Bert[SUP] 1 [/SUP], Antonio Bertoletti[SUP] 6 [/SUP], Anthony T Tan[SUP] 7 [/SUP]
Affiliations
- PMID: 36257326
- DOI: 10.1016/j.xcrm.2022.100793
Abstract
Unlike mRNA vaccines based only on the spike protein, inactivated severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines should induce a diversified T cell response recognizing distinct structural proteins. Here, we perform a comparative analysis of SARS-CoV-2-specific T cells in healthy individuals following vaccination with inactivated SARS-CoV-2 or mRNA vaccines. Relative to spike mRNA vaccination, inactivated vaccines elicit a lower magnitude of spike-specific T cells, but the combination of membrane, nucleoprotein, and spike-specific T cell response is quantitatively comparable with the sole spike T cell response induced by mRNA vaccine, and they efficiently tolerate the mutations characterizing the Omicron lineage. However, this multi-protein-specific T cell response is not mediated by a coordinated CD4 and CD8 T cell expansion but by selective priming of CD4 T cells. These findings can help in understanding the role of CD4 and CD8 T cells in the efficacy of the different vaccines to control severe COVID-19 after Omicron infection.
Keywords: COVID-19; T cell response; adaptive immune response; inactivated vaccine.