tetano
Editor, Senior Moderator
Cell Rep
. 2022 Jan 19;110345.
doi: 10.1016/j.celrep.2022.110345. Online ahead of print.
Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses
Harikrishnan Balachandran[SUP] 1 [/SUP], Chansavath Phetsouphanh[SUP] 2 [/SUP], David Agapiou[SUP] 2 [/SUP], Anurag Adhikari[SUP] 3 [/SUP], Chaturaka Rodrigo[SUP] 1 [/SUP], Mohamed Hammoud[SUP] 2 [/SUP], Lok Bahadur Shrestha[SUP] 1 [/SUP], Elizabeth Keoshkerian[SUP] 2 [/SUP], Money Gupta[SUP] 1 [/SUP], Stuart Turville[SUP] 2 [/SUP], Daniel Christ[SUP] 4 [/SUP], Cecile King[SUP] 4 [/SUP], Sarah C Sasson[SUP] 2 [/SUP], Adam Bartlett[SUP] 5 [/SUP], Branka Grubor-Bauk[SUP] 6 [/SUP], William Rawlinson[SUP] 7 [/SUP], Anupriya Aggarwal[SUP] 2 [/SUP], Alberto Ospina Stella[SUP] 2 [/SUP], Vera Klemm[SUP] 2 [/SUP], Michael M Mina[SUP] 8 [/SUP], Jeffrey J Post[SUP] 9 [/SUP], Bernard Hudson[SUP] 10 [/SUP], Nicky Gilroy[SUP] 11 [/SUP], Pam Konecny[SUP] 12 [/SUP], Golo Ahlenstiel[SUP] 13 [/SUP], Dominic E Dwyer[SUP] 14 [/SUP], Tania C Sorrell[SUP] 15 [/SUP], Anthony Kelleher[SUP] 2 [/SUP], Nicodemus Tedla[SUP] 16 [/SUP], Andrew R Lloyd[SUP] 2 [/SUP], Marianne Martinello[SUP] 17 [/SUP], Rowena A Bull[SUP] 18 [/SUP], COSIN Study Group
Affiliations
Abstract
Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%-76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection.
Keywords: 12 months after SARS-CoV-2 infection; Delta variant; RBD-specific memory B cells longevity; SARS-CoV-2; SARS-CoV-2 OX40 CD4 T cell assay; SARS-CoV-2 antibody duration; SARS-CoV-2 neutralization; protection efficacy prediction; variants of concern.
. 2022 Jan 19;110345.
doi: 10.1016/j.celrep.2022.110345. Online ahead of print.
Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses
Harikrishnan Balachandran[SUP] 1 [/SUP], Chansavath Phetsouphanh[SUP] 2 [/SUP], David Agapiou[SUP] 2 [/SUP], Anurag Adhikari[SUP] 3 [/SUP], Chaturaka Rodrigo[SUP] 1 [/SUP], Mohamed Hammoud[SUP] 2 [/SUP], Lok Bahadur Shrestha[SUP] 1 [/SUP], Elizabeth Keoshkerian[SUP] 2 [/SUP], Money Gupta[SUP] 1 [/SUP], Stuart Turville[SUP] 2 [/SUP], Daniel Christ[SUP] 4 [/SUP], Cecile King[SUP] 4 [/SUP], Sarah C Sasson[SUP] 2 [/SUP], Adam Bartlett[SUP] 5 [/SUP], Branka Grubor-Bauk[SUP] 6 [/SUP], William Rawlinson[SUP] 7 [/SUP], Anupriya Aggarwal[SUP] 2 [/SUP], Alberto Ospina Stella[SUP] 2 [/SUP], Vera Klemm[SUP] 2 [/SUP], Michael M Mina[SUP] 8 [/SUP], Jeffrey J Post[SUP] 9 [/SUP], Bernard Hudson[SUP] 10 [/SUP], Nicky Gilroy[SUP] 11 [/SUP], Pam Konecny[SUP] 12 [/SUP], Golo Ahlenstiel[SUP] 13 [/SUP], Dominic E Dwyer[SUP] 14 [/SUP], Tania C Sorrell[SUP] 15 [/SUP], Anthony Kelleher[SUP] 2 [/SUP], Nicodemus Tedla[SUP] 16 [/SUP], Andrew R Lloyd[SUP] 2 [/SUP], Marianne Martinello[SUP] 17 [/SUP], Rowena A Bull[SUP] 18 [/SUP], COSIN Study Group
Affiliations
- PMID: 35090598
- DOI: 10.1016/j.celrep.2022.110345
Abstract
Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%-76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection.
Keywords: 12 months after SARS-CoV-2 infection; Delta variant; RBD-specific memory B cells longevity; SARS-CoV-2; SARS-CoV-2 OX40 CD4 T cell assay; SARS-CoV-2 antibody duration; SARS-CoV-2 neutralization; protection efficacy prediction; variants of concern.