tetano
Editor, Senior Moderator
Cell Mol Life Sci
. 2021 Jul 5.
doi: 10.1007/s00018-021-03889-5. Online ahead of print.
Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs
Sébastien Boutin[SUP] 1 2 [/SUP], Dagmar Hildebrand[SUP] 3 [/SUP], Steeve Boulant[SUP] 4 5 [/SUP], Michael Kreuter[SUP] 6 7 [/SUP], Jule Rüter[SUP] 8 [/SUP], Srinivas Reddy Pallerla[SUP] 8 [/SUP], Thirumalaisamy P Velavan[SUP] 8 9 [/SUP], Dennis Nurjadi[SUP] 3 [/SUP]
Affiliations
Abstract
SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host's microbiome and secondary infection which also worsen the disease.
Keywords: COVID-19; Co-morbidities; Host factor; Innate immune response; Microbiome; SARS-CoV-2.
. 2021 Jul 5.
doi: 10.1007/s00018-021-03889-5. Online ahead of print.
Host factors facilitating SARS-CoV-2 virus infection and replication in the lungs
Sébastien Boutin[SUP] 1 2 [/SUP], Dagmar Hildebrand[SUP] 3 [/SUP], Steeve Boulant[SUP] 4 5 [/SUP], Michael Kreuter[SUP] 6 7 [/SUP], Jule Rüter[SUP] 8 [/SUP], Srinivas Reddy Pallerla[SUP] 8 [/SUP], Thirumalaisamy P Velavan[SUP] 8 9 [/SUP], Dennis Nurjadi[SUP] 3 [/SUP]
Affiliations
- PMID: 34223911
- DOI: 10.1007/s00018-021-03889-5
Abstract
SARS-CoV-2 is the virus causing the major pandemic facing the world today. Although, SARS-CoV-2 primarily causes lung infection, a variety of symptoms have proven a systemic impact on the body. SARS-CoV-2 has spread in the community quickly infecting humans from all age, ethnicities and gender. However, fatal outcomes have been linked to specific host factors and co-morbidities such as age, hypertension, immuno-deficiencies, chronic lung diseases or metabolic disorders. A major shift in the microbiome of patients suffering of the coronavirus disease 2019 (COVID-19) have also been observed and is linked to a worst outcome of the disease. As many co-morbidities are already known to be associated with a dysbiosis of the microbiome such as hypertension, diabetes and metabolic disorders. Host factors and microbiome changes are believed to be involved as a network in the acquisition of the infection and the development of the diseases. We will review in detail in this manuscript, the immune response toward SARS-CoV-2 infection as well as the host factors involved in the facilitation and worsening of the infection. We will also address the impact of COVID-19 on the host's microbiome and secondary infection which also worsen the disease.
Keywords: COVID-19; Co-morbidities; Host factor; Innate immune response; Microbiome; SARS-CoV-2.