tetano
Editor, Senior Moderator
Cell Mol Immunol
. 2021 Jul 21.
doi: 10.1038/s41423-021-00728-2. Online ahead of print.
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
Alberto Pérez-Gómez[SUP] #[/SUP][SUP] 1 [/SUP], Joana Vitallé[SUP] #[/SUP][SUP] 1 [/SUP], Carmen Gasca-Capote[SUP] #[/SUP][SUP] 1 [/SUP], Alicia Gutierrez-Valencia[SUP] 1 [/SUP], María Trujillo-Rodriguez[SUP] 1 [/SUP], Ana Serna-Gallego[SUP] 1 [/SUP], Esperanza Muñoz-Muela[SUP] 1 [/SUP], María de Los Reyes Jiménez-Leon[SUP] 1 [/SUP], Mohamed Rafii-El-Idrissi Benhnia[SUP] 1 2 [/SUP], Inmaculada Rivas-Jeremias[SUP] 1 [/SUP], Cesar Sotomayor[SUP] 1 [/SUP], Cristina Roca-Oporto[SUP] 1 [/SUP], Nuria Espinosa[SUP] 1 [/SUP], Carmen Infante-Domínguez[SUP] 1 [/SUP], Juan Carlos Crespo-Rivas[SUP] 1 [/SUP], Alberto Fernández-Villar[SUP] 3 [/SUP], Alexandre Pérez-González[SUP] 4 5 [/SUP], Luis Fernando López-Cortés[SUP] 1 [/SUP], Eva Poveda[SUP] 5 [/SUP], Ezequiel Ruiz-Mateos[SUP] 6 [/SUP], Virgen del Rocío Hospital COVID-19 Working Team
Collaborators, Affiliations
Abstract
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19.
Keywords: COVID-19; Dendritic cell; Long-COVID; SARS-CoV-2.
. 2021 Jul 21.
doi: 10.1038/s41423-021-00728-2. Online ahead of print.
Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection
Alberto Pérez-Gómez[SUP] #[/SUP][SUP] 1 [/SUP], Joana Vitallé[SUP] #[/SUP][SUP] 1 [/SUP], Carmen Gasca-Capote[SUP] #[/SUP][SUP] 1 [/SUP], Alicia Gutierrez-Valencia[SUP] 1 [/SUP], María Trujillo-Rodriguez[SUP] 1 [/SUP], Ana Serna-Gallego[SUP] 1 [/SUP], Esperanza Muñoz-Muela[SUP] 1 [/SUP], María de Los Reyes Jiménez-Leon[SUP] 1 [/SUP], Mohamed Rafii-El-Idrissi Benhnia[SUP] 1 2 [/SUP], Inmaculada Rivas-Jeremias[SUP] 1 [/SUP], Cesar Sotomayor[SUP] 1 [/SUP], Cristina Roca-Oporto[SUP] 1 [/SUP], Nuria Espinosa[SUP] 1 [/SUP], Carmen Infante-Domínguez[SUP] 1 [/SUP], Juan Carlos Crespo-Rivas[SUP] 1 [/SUP], Alberto Fernández-Villar[SUP] 3 [/SUP], Alexandre Pérez-González[SUP] 4 5 [/SUP], Luis Fernando López-Cortés[SUP] 1 [/SUP], Eva Poveda[SUP] 5 [/SUP], Ezequiel Ruiz-Mateos[SUP] 6 [/SUP], Virgen del Rocío Hospital COVID-19 Working Team
Collaborators, Affiliations
- PMID: 34290398
- DOI: 10.1038/s41423-021-00728-2
Abstract
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19.
Keywords: COVID-19; Dendritic cell; Long-COVID; SARS-CoV-2.