tetano
Editor, Senior Moderator
Cell Mol Biol Lett
. 2022 Feb 2;27(1):10.
doi: 10.1186/s11658-022-00311-1.
The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies
Hamidreza Zalpoor[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Abdullatif Akbari[SUP] #[/SUP][SUP] 4 [/SUP], Azam Samei[SUP] 5 [/SUP], Razieh Forghaniesfidvajani[SUP] 4 [/SUP], Monireh Kamali[SUP] 6 [/SUP], Azadeh Afzalnia[SUP] 6 [/SUP], Shirin Manshouri[SUP] 6 [/SUP], Fatemeh Heidari[SUP] 7 [/SUP], Majid Pornour[SUP] 8 [/SUP], Majid Khoshmirsafa[SUP] 9 [/SUP], Hossein Aazami[SUP] 10 [/SUP], Farhad Seif[SUP] 11 12 [/SUP]
Affiliations
Abstract
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, elucidation of pathogenesis mechanisms, especially entry routes of SARS-CoV-2 may help propose antiviral drugs and novel vaccines. Several receptors have been demonstrated for the interaction of spike (S) protein of SARS-CoV-2 with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands and Eph receptors, neuropilin 1 (NRP-1), P2X7, and CD147. The expression of these entry receptors in the central nervous system (CNS) may make the CNS prone to SARS-CoV-2 invasion, leading to neurodegenerative diseases. The present review provides potential pathological mechanisms of SARS-CoV-2 infection in the CNS, including entry receptors and cytokines involved in neuroinflammatory conditions. Moreover, it explains several neurodegenerative disorders associated with COVID-19. Finally, we suggest inflammasome and JaK inhibitors as potential therapeutic strategies for neurodegenerative diseases.
Keywords: Alzheimer’s disease; CD147; CNS; COVID-19; Cytokine; Ephrin; Inflammasome; Jak; Neurodegenerative diseases; Neuropilin-1; P2X7; Parkinson’s disease.
. 2022 Feb 2;27(1):10.
doi: 10.1186/s11658-022-00311-1.
The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies
Hamidreza Zalpoor[SUP] #[/SUP][SUP] 1 2 3 [/SUP], Abdullatif Akbari[SUP] #[/SUP][SUP] 4 [/SUP], Azam Samei[SUP] 5 [/SUP], Razieh Forghaniesfidvajani[SUP] 4 [/SUP], Monireh Kamali[SUP] 6 [/SUP], Azadeh Afzalnia[SUP] 6 [/SUP], Shirin Manshouri[SUP] 6 [/SUP], Fatemeh Heidari[SUP] 7 [/SUP], Majid Pornour[SUP] 8 [/SUP], Majid Khoshmirsafa[SUP] 9 [/SUP], Hossein Aazami[SUP] 10 [/SUP], Farhad Seif[SUP] 11 12 [/SUP]
Affiliations
- PMID: 35109786
- DOI: 10.1186/s11658-022-00311-1
Abstract
The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, elucidation of pathogenesis mechanisms, especially entry routes of SARS-CoV-2 may help propose antiviral drugs and novel vaccines. Several receptors have been demonstrated for the interaction of spike (S) protein of SARS-CoV-2 with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands and Eph receptors, neuropilin 1 (NRP-1), P2X7, and CD147. The expression of these entry receptors in the central nervous system (CNS) may make the CNS prone to SARS-CoV-2 invasion, leading to neurodegenerative diseases. The present review provides potential pathological mechanisms of SARS-CoV-2 infection in the CNS, including entry receptors and cytokines involved in neuroinflammatory conditions. Moreover, it explains several neurodegenerative disorders associated with COVID-19. Finally, we suggest inflammasome and JaK inhibitors as potential therapeutic strategies for neurodegenerative diseases.
Keywords: Alzheimer’s disease; CD147; CNS; COVID-19; Cytokine; Ephrin; Inflammasome; Jak; Neurodegenerative diseases; Neuropilin-1; P2X7; Parkinson’s disease.