tetano
Editor, Senior Moderator
Cell
. 2022 Mar 17;S0092-8674(22)00328-2.
doi: 10.1016/j.cell.2022.03.018. Online ahead of print.
Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity
Lauren B Rodda[SUP] 1 [/SUP], Peter A Morawski[SUP] 2 [/SUP], Kurt B Pruner[SUP] 1 [/SUP], Mitchell L Fahning[SUP] 2 [/SUP], Christian A Howard[SUP] 1 [/SUP], Nicholas Franko[SUP] 3 [/SUP], Jennifer Logue[SUP] 3 [/SUP], Julie Eggenberger[SUP] 4 [/SUP], Caleb Stokes[SUP] 4 [/SUP], Inah Golez[SUP] 4 [/SUP], Malika Hale[SUP] 5 [/SUP], Michael Gale Jr[SUP] 4 [/SUP], Helen Y Chu[SUP] 3 [/SUP], Daniel J Campbell[SUP] 6 [/SUP], Marion Pepper[SUP] 7 [/SUP]
Affiliations
Abstract
Immune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen exposures. Both SARS-CoV-2 infection and vaccination induce multifaceted, functional immune memory, but together, they engender improved protection from disease, termed hybrid immunity. We therefore investigated how vaccine-induced memory is shaped by previous infection. We found that following vaccination, previously infected individuals generated more SARS-CoV-2 RBD-specific memory B cells and variant-neutralizing antibodies and a distinct population of IFN-γ and IL-10-expressing memory SARS-CoV-2 spike-specific CD4[SUP]+[/SUP] T cells than previously naive individuals. Although additional vaccination could increase humoral memory in previously naive individuals, it did not recapitulate the distinct CD4[SUP]+[/SUP] T cell cytokine profile observed in previously infected subjects. Thus, imprinted features of SARS-CoV-2-specific memory lymphocytes define hybrid immunity.
Keywords: COVID-19; SARS-CoV-2; adaptive immune response; human; hybrid Immunity; memory B cell; memory T cell; vaccine.
. 2022 Mar 17;S0092-8674(22)00328-2.
doi: 10.1016/j.cell.2022.03.018. Online ahead of print.
Imprinted SARS-CoV-2-specific memory lymphocytes define hybrid immunity
Lauren B Rodda[SUP] 1 [/SUP], Peter A Morawski[SUP] 2 [/SUP], Kurt B Pruner[SUP] 1 [/SUP], Mitchell L Fahning[SUP] 2 [/SUP], Christian A Howard[SUP] 1 [/SUP], Nicholas Franko[SUP] 3 [/SUP], Jennifer Logue[SUP] 3 [/SUP], Julie Eggenberger[SUP] 4 [/SUP], Caleb Stokes[SUP] 4 [/SUP], Inah Golez[SUP] 4 [/SUP], Malika Hale[SUP] 5 [/SUP], Michael Gale Jr[SUP] 4 [/SUP], Helen Y Chu[SUP] 3 [/SUP], Daniel J Campbell[SUP] 6 [/SUP], Marion Pepper[SUP] 7 [/SUP]
Affiliations
- PMID: 35413241
- DOI: 10.1016/j.cell.2022.03.018
Abstract
Immune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen exposures. Both SARS-CoV-2 infection and vaccination induce multifaceted, functional immune memory, but together, they engender improved protection from disease, termed hybrid immunity. We therefore investigated how vaccine-induced memory is shaped by previous infection. We found that following vaccination, previously infected individuals generated more SARS-CoV-2 RBD-specific memory B cells and variant-neutralizing antibodies and a distinct population of IFN-γ and IL-10-expressing memory SARS-CoV-2 spike-specific CD4[SUP]+[/SUP] T cells than previously naive individuals. Although additional vaccination could increase humoral memory in previously naive individuals, it did not recapitulate the distinct CD4[SUP]+[/SUP] T cell cytokine profile observed in previously infected subjects. Thus, imprinted features of SARS-CoV-2-specific memory lymphocytes define hybrid immunity.
Keywords: COVID-19; SARS-CoV-2; adaptive immune response; human; hybrid Immunity; memory B cell; memory T cell; vaccine.