tetano
Editor, Senior Moderator
Cell Host Microbe
. 2020 May 20;S1931-3128(20)30291-2.
doi: 10.1016/j.chom.2020.05.009. Online ahead of print.
The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
Julia L McKechnie[SUP] 1 [/SUP], Catherine A Blish[SUP] 2 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.
Keywords: COVID-19; SARS-CoV-2; complement; cytokines; innate immune response; myeloid cells; natural killer cells.
. 2020 May 20;S1931-3128(20)30291-2.
doi: 10.1016/j.chom.2020.05.009. Online ahead of print.
The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?
Julia L McKechnie[SUP] 1 [/SUP], Catherine A Blish[SUP] 2 [/SUP]
Affiliations
- PMID: 32464098
- DOI: 10.1016/j.chom.2020.05.009
Abstract
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.
Keywords: COVID-19; SARS-CoV-2; complement; cytokines; innate immune response; myeloid cells; natural killer cells.