tetano
Editor, Senior Moderator
Cell Host Microbe
. 2021 Jun 4;S1931-3128(21)00279-1.
doi: 10.1016/j.chom.2021.06.001. Online ahead of print.
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses
Alexandra Tauzin[SUP] 1 [/SUP], Manon Nayrac[SUP] 1 [/SUP], Mehdi Benlarbi[SUP] 2 [/SUP], Shang Yu Gong[SUP] 3 [/SUP], Romain Gasser[SUP] 1 [/SUP], Guillaume Beaudoin-Bussières[SUP] 1 [/SUP], Nathalie Brassard[SUP] 2 [/SUP], Annemarie Laumaea[SUP] 1 [/SUP], Dani Vézina[SUP] 1 [/SUP], Jérémie Prévost[SUP] 1 [/SUP], Sai Priya Anand[SUP] 3 [/SUP], Catherine Bourassa[SUP] 2 [/SUP], Gabrielle Gendron-Lepage[SUP] 2 [/SUP], Halima Medjahed[SUP] 2 [/SUP], Guillaume Goyette[SUP] 2 [/SUP], Julia Niessl[SUP] 4 [/SUP], Olivier Tastet[SUP] 2 [/SUP], Laurie Gokool[SUP] 2 [/SUP], Chantal Morrisseau[SUP] 2 [/SUP], Pascale Arlotto[SUP] 2 [/SUP], Leonidas Stamatatos[SUP] 5 [/SUP], Andrew T McGuire[SUP] 6 [/SUP], Catherine Larochelle[SUP] 7 [/SUP], Pradeep Uchil[SUP] 8 [/SUP], Maolin Lu[SUP] 8 [/SUP], Walther Mothes[SUP] 8 [/SUP], Gaston De Serres[SUP] 9 [/SUP], Sandrine Moreira[SUP] 10 [/SUP], Michel Roger[SUP] 11 [/SUP], Jonathan Richard[SUP] 1 [/SUP], Valérie Martel-Laferrière[SUP] 1 [/SUP], Ralf Duerr[SUP] 12 [/SUP], Cécile Tremblay[SUP] 13 [/SUP], Daniel E Kaufmann[SUP] 14 [/SUP], Andrés Finzi[SUP] 15 [/SUP]
Affiliations
Abstract
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses administered 3 weeks apart, some public health authorities are spacing these doses, raising concerns about efficacy. However, data indicate that a single dose can be up to 90% effective starting 14 days post-administration. To assess the mechanisms contributing to protection, we analyzed humoral and T cell responses three weeks after a single BNT162b2 dose. We observed weak neutralizing activity elicited in SARS-CoV-2 naive individuals but strong anti-receptor binding domain and spike antibodies with Fc-mediated effector functions and cellular CD4[SUP]+[/SUP] T cell responses. In previously infected individuals, a single dose boosted all humoral and T cell responses, with strong correlations between T helper and antibody immunity. Our results highlight the potential role of Fc-mediated effector functions and T cell responses in vaccine efficacy. They also provide support for spacing doses to vaccinate more individuals in conditions of vaccine scarcity.
Keywords: ADCC; COVID-19; SARS-CoV-2; T cell responses; coronavirus; humoral responses; mRNA vaccine; neutralization; spike glycoproteins; variants.
. 2021 Jun 4;S1931-3128(21)00279-1.
doi: 10.1016/j.chom.2021.06.001. Online ahead of print.
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses
Alexandra Tauzin[SUP] 1 [/SUP], Manon Nayrac[SUP] 1 [/SUP], Mehdi Benlarbi[SUP] 2 [/SUP], Shang Yu Gong[SUP] 3 [/SUP], Romain Gasser[SUP] 1 [/SUP], Guillaume Beaudoin-Bussières[SUP] 1 [/SUP], Nathalie Brassard[SUP] 2 [/SUP], Annemarie Laumaea[SUP] 1 [/SUP], Dani Vézina[SUP] 1 [/SUP], Jérémie Prévost[SUP] 1 [/SUP], Sai Priya Anand[SUP] 3 [/SUP], Catherine Bourassa[SUP] 2 [/SUP], Gabrielle Gendron-Lepage[SUP] 2 [/SUP], Halima Medjahed[SUP] 2 [/SUP], Guillaume Goyette[SUP] 2 [/SUP], Julia Niessl[SUP] 4 [/SUP], Olivier Tastet[SUP] 2 [/SUP], Laurie Gokool[SUP] 2 [/SUP], Chantal Morrisseau[SUP] 2 [/SUP], Pascale Arlotto[SUP] 2 [/SUP], Leonidas Stamatatos[SUP] 5 [/SUP], Andrew T McGuire[SUP] 6 [/SUP], Catherine Larochelle[SUP] 7 [/SUP], Pradeep Uchil[SUP] 8 [/SUP], Maolin Lu[SUP] 8 [/SUP], Walther Mothes[SUP] 8 [/SUP], Gaston De Serres[SUP] 9 [/SUP], Sandrine Moreira[SUP] 10 [/SUP], Michel Roger[SUP] 11 [/SUP], Jonathan Richard[SUP] 1 [/SUP], Valérie Martel-Laferrière[SUP] 1 [/SUP], Ralf Duerr[SUP] 12 [/SUP], Cécile Tremblay[SUP] 13 [/SUP], Daniel E Kaufmann[SUP] 14 [/SUP], Andrés Finzi[SUP] 15 [/SUP]
Affiliations
- PMID: 34133950
- DOI: 10.1016/j.chom.2021.06.001
Abstract
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses administered 3 weeks apart, some public health authorities are spacing these doses, raising concerns about efficacy. However, data indicate that a single dose can be up to 90% effective starting 14 days post-administration. To assess the mechanisms contributing to protection, we analyzed humoral and T cell responses three weeks after a single BNT162b2 dose. We observed weak neutralizing activity elicited in SARS-CoV-2 naive individuals but strong anti-receptor binding domain and spike antibodies with Fc-mediated effector functions and cellular CD4[SUP]+[/SUP] T cell responses. In previously infected individuals, a single dose boosted all humoral and T cell responses, with strong correlations between T helper and antibody immunity. Our results highlight the potential role of Fc-mediated effector functions and T cell responses in vaccine efficacy. They also provide support for spacing doses to vaccinate more individuals in conditions of vaccine scarcity.
Keywords: ADCC; COVID-19; SARS-CoV-2; T cell responses; coronavirus; humoral responses; mRNA vaccine; neutralization; spike glycoproteins; variants.