tetano
Editor, Senior Moderator
Cell Discov
. 2021 Mar 25;7(1):18.
doi: 10.1038/s41421-021-00250-9.
Immune memory in convalescent patients with asymptomatic or mild COVID-19
Quan-Xin Long[SUP] #[/SUP][SUP] 1 [/SUP], Yan-Jun Jia[SUP] #[/SUP][SUP] 2 [/SUP], Xin Wang[SUP] #[/SUP][SUP] 1 [/SUP], Hai-Jun Deng[SUP] #[/SUP][SUP] 1 [/SUP], Xiao-Xia Cao[SUP] #[/SUP][SUP] 1 [/SUP], Jun Yuan[SUP] 1 [/SUP], Liang Fang[SUP] 3 [/SUP], Xu-Rong Cheng[SUP] 3 [/SUP], Chao Luo[SUP] 4 [/SUP], An-Ran He[SUP] 4 [/SUP], Xiao-Jun Tang[SUP] 5 [/SUP], Jie-Li Hu[SUP] 1 [/SUP], Yuan Hu[SUP] 1 [/SUP], Ni Tang[SUP] 1 [/SUP], Xue-Fei Cai[SUP] 1 [/SUP], De-Qiang Wang[SUP] 1 [/SUP], Jie Hu[SUP] 1 [/SUP], Jing-Fu Qiu[SUP] 5 [/SUP], Bei-Zhong Liu[SUP] 3 [/SUP], Juan Chen[SUP] 6 [/SUP], Ai-Long Huang[SUP] 7 [/SUP]
Affiliations
Abstract
It is important to evaluate the durability of the protective immune response elicited by primary infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we systematically evaluated the SARS-CoV-2-specific memory B cell and T cell responses in healthy controls and individuals recovered from asymptomatic or symptomatic infection approximately 6 months prior. Comparatively low frequencies of memory B cells specific for the receptor-binding domain (RBD) of spike glycoprotein (S) persisted in the peripheral blood of individuals who recovered from infection (median 0.62%, interquartile range 0.48-0.69). The SARS-CoV-2 RBD-specific memory B cell response was detected in 2 of 13 individuals who recovered from asymptomatic infection and 10 of 20 individuals who recovered from symptomatic infection. T cell responses induced by S, membrane (M), and nucleocapsid (N) peptide libraries from SARS-CoV-2 were observed in individuals recovered from coronavirus disease 2019 (COVID-19), and cross-reactive T cell responses to SARS-CoV-2 were also detected in healthy controls.
. 2021 Mar 25;7(1):18.
doi: 10.1038/s41421-021-00250-9.
Immune memory in convalescent patients with asymptomatic or mild COVID-19
Quan-Xin Long[SUP] #[/SUP][SUP] 1 [/SUP], Yan-Jun Jia[SUP] #[/SUP][SUP] 2 [/SUP], Xin Wang[SUP] #[/SUP][SUP] 1 [/SUP], Hai-Jun Deng[SUP] #[/SUP][SUP] 1 [/SUP], Xiao-Xia Cao[SUP] #[/SUP][SUP] 1 [/SUP], Jun Yuan[SUP] 1 [/SUP], Liang Fang[SUP] 3 [/SUP], Xu-Rong Cheng[SUP] 3 [/SUP], Chao Luo[SUP] 4 [/SUP], An-Ran He[SUP] 4 [/SUP], Xiao-Jun Tang[SUP] 5 [/SUP], Jie-Li Hu[SUP] 1 [/SUP], Yuan Hu[SUP] 1 [/SUP], Ni Tang[SUP] 1 [/SUP], Xue-Fei Cai[SUP] 1 [/SUP], De-Qiang Wang[SUP] 1 [/SUP], Jie Hu[SUP] 1 [/SUP], Jing-Fu Qiu[SUP] 5 [/SUP], Bei-Zhong Liu[SUP] 3 [/SUP], Juan Chen[SUP] 6 [/SUP], Ai-Long Huang[SUP] 7 [/SUP]
Affiliations
- PMID: 33767156
- DOI: 10.1038/s41421-021-00250-9
Abstract
It is important to evaluate the durability of the protective immune response elicited by primary infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we systematically evaluated the SARS-CoV-2-specific memory B cell and T cell responses in healthy controls and individuals recovered from asymptomatic or symptomatic infection approximately 6 months prior. Comparatively low frequencies of memory B cells specific for the receptor-binding domain (RBD) of spike glycoprotein (S) persisted in the peripheral blood of individuals who recovered from infection (median 0.62%, interquartile range 0.48-0.69). The SARS-CoV-2 RBD-specific memory B cell response was detected in 2 of 13 individuals who recovered from asymptomatic infection and 10 of 20 individuals who recovered from symptomatic infection. T cell responses induced by S, membrane (M), and nucleocapsid (N) peptide libraries from SARS-CoV-2 were observed in individuals recovered from coronavirus disease 2019 (COVID-19), and cross-reactive T cell responses to SARS-CoV-2 were also detected in healthy controls.