tetano
Editor, Senior Moderator
Cell
. 2023 Feb 2;S0092-8674(23)00098-3.
doi: 10.1016/j.cell.2023.01.039. Online ahead of print.
Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic
Gavin Y Oudit[SUP] 1 [/SUP], Kaiming Wang[SUP] 2 [/SUP], Anissa Viveiros[SUP] 2 [/SUP], Max J Kellner[SUP] 3 [/SUP], Josef M Penninger[SUP] 4 [/SUP]
Affiliations
Abstract
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance; as a chaperone, it controls intestinal amino acid uptake. ACE2's tissue distribution, affected by co-morbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses exploiting ACE2 as their cellular receptor.
. 2023 Feb 2;S0092-8674(23)00098-3.
doi: 10.1016/j.cell.2023.01.039. Online ahead of print.
Angiotensin-converting enzyme 2-at the heart of the COVID-19 pandemic
Gavin Y Oudit[SUP] 1 [/SUP], Kaiming Wang[SUP] 2 [/SUP], Anissa Viveiros[SUP] 2 [/SUP], Max J Kellner[SUP] 3 [/SUP], Josef M Penninger[SUP] 4 [/SUP]
Affiliations
- PMID: 36787743
- DOI: 10.1016/j.cell.2023.01.039
Abstract
ACE2 is the indispensable entry receptor for SARS-CoV and SARS-CoV-2. Because of the COVID-19 pandemic, it has become one of the most therapeutically targeted human molecules in biomedicine. ACE2 serves two fundamental physiological roles: as an enzyme, it alters peptide cascade balance; as a chaperone, it controls intestinal amino acid uptake. ACE2's tissue distribution, affected by co-morbidities and sex, explains the broad tropism of coronaviruses and the clinical manifestations of SARS and COVID-19. ACE2-based therapeutics provide a universal strategy to prevent and treat SARS-CoV-2 infections, applicable to all SARS-CoV-2 variants and other emerging zoonotic coronaviruses exploiting ACE2 as their cellular receptor.