tetano
Editor, Senior Moderator
Mediators Inflamm. 2014;2014:921054. doi: 10.1155/2014/921054. Epub 2014 Nov 25.
[h=1]CD206+ Cell Number Differentiates Influenza A (H1N1)pdm09 from Seasonal Influenza A Virus in Fatal Cases.[/h] Rodriguez-Ramirez HG[SUP]1[/SUP], Salinas-Carmona MC[SUP]1[/SUP], Barboza-Quintana O[SUP]2[/SUP], Melo-de la Garza A[SUP]2[/SUP], Cece?as-Falcon LA[SUP]2[/SUP], Rangel-Martinez LM[SUP]3[/SUP], Rosas-Taraco AG[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In 2009, a new influenza A (H1N1) virus affected many persons around the world. There is an urgent need for finding biomarkers to distinguish between influenza A (H1N1)pdm09 and seasonal influenza virus. We investigated these possible biomarkers in the lung of fatal cases of confirmed influenza A (H1N1)pdm09. Cytokines (inflammatory and anti-inflammatory) and cellular markers (macrophages and lymphocytes subpopulation markers) were analyzed in lung tissue from both influenza A (H1N1)pdm09 and seasonal influenza virus. High levels of IL-17, IFN-γ, and TNF-α positive cells were identical in lung tissue from the influenza A (H1N1)pdm09 and seasonal cases when compared with healthy lung tissue (P < 0.05). Increased IL-4+ cells, and CD4+ and CD14+ cells were also found in high levels in both influenza A (H1N1)pdm09 and seasonal influenza virus (P < 0.05). Low levels of CD206+ cells (marker of alternatively activated macrophages marker in lung) were found in influenza A (H1N1)pdm09 when compared with seasonal influenza virus (P < 0.05), and the ratio of CD206/CD14+ cells was 2.5-fold higher in seasonal and noninfluenza group compared with influenza A (H1N1)pdm09 (P < 0.05). In conclusion, CD206+ cells differentiate between influenza A (H1N1)pdm09 and seasonal influenza virus in lung tissue of fatal cases.
PMID: 25614715 [PubMed - in process] PMCID: PMC4295401 Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/25614715
[h=1]CD206+ Cell Number Differentiates Influenza A (H1N1)pdm09 from Seasonal Influenza A Virus in Fatal Cases.[/h] Rodriguez-Ramirez HG[SUP]1[/SUP], Salinas-Carmona MC[SUP]1[/SUP], Barboza-Quintana O[SUP]2[/SUP], Melo-de la Garza A[SUP]2[/SUP], Cece?as-Falcon LA[SUP]2[/SUP], Rangel-Martinez LM[SUP]3[/SUP], Rosas-Taraco AG[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In 2009, a new influenza A (H1N1) virus affected many persons around the world. There is an urgent need for finding biomarkers to distinguish between influenza A (H1N1)pdm09 and seasonal influenza virus. We investigated these possible biomarkers in the lung of fatal cases of confirmed influenza A (H1N1)pdm09. Cytokines (inflammatory and anti-inflammatory) and cellular markers (macrophages and lymphocytes subpopulation markers) were analyzed in lung tissue from both influenza A (H1N1)pdm09 and seasonal influenza virus. High levels of IL-17, IFN-γ, and TNF-α positive cells were identical in lung tissue from the influenza A (H1N1)pdm09 and seasonal cases when compared with healthy lung tissue (P < 0.05). Increased IL-4+ cells, and CD4+ and CD14+ cells were also found in high levels in both influenza A (H1N1)pdm09 and seasonal influenza virus (P < 0.05). Low levels of CD206+ cells (marker of alternatively activated macrophages marker in lung) were found in influenza A (H1N1)pdm09 when compared with seasonal influenza virus (P < 0.05), and the ratio of CD206/CD14+ cells was 2.5-fold higher in seasonal and noninfluenza group compared with influenza A (H1N1)pdm09 (P < 0.05). In conclusion, CD206+ cells differentiate between influenza A (H1N1)pdm09 and seasonal influenza virus in lung tissue of fatal cases.
PMID: 25614715 [PubMed - in process] PMCID: PMC4295401 Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/25614715