tetano
Editor, Senior Moderator
J Gen Virol. 2015 Apr 27. pii: vir.0.000165. doi: 10.1099/vir.0.000165. [Epub ahead of print]
[h=1]CCR5 deficiency predisposes to fatal outcome in influenza virus infection.[/h] Falcon A[SUP]1[/SUP], Cuevas MT[SUP]2[/SUP], Rodriguez-Frandsen A[SUP]3[/SUP], Reyes N[SUP]2[/SUP], Pozo F[SUP]2[/SUP], Moreno S[SUP]2[/SUP], Ledesma J[SUP]2[/SUP], Mart?nez-Alarc?n J[SUP]4[/SUP], Nieto A[SUP]5[/SUP], Casas I[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza epidemics affect all age groups, although children, the elderly, and those with underlying medical conditions are the most severely affected. Whereas co-morbidities are present in 50% of fatal cases, 25-50% of deaths are of apparently healthy individuals. This suggests underlying genetic determinants that govern infection severity. Although some viral factors that contribute to influenza disease are known, the role of host genetic factors remains undetermined. Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency (CCR5-Δ32 mutation, a 32-base pair deletion in CCR5) in the outcome of influenza virus infection. We tested 171 respiratory samples from influenza patients (2009 pandemic) for CCR5-Δ32 and evaluated its correlation with patient mortality. CCR5-Δ32 patients (17.4%) showed a higher mortality rate than wild-type individuals (4.7%; p = 0.021), which indicates that CCR5-Δ32 patients are at higher risk than the normal population of fatal outcome in influenza infection.
PMID: 25918237 [PubMed - as supplied by publisher]
[h=1]CCR5 deficiency predisposes to fatal outcome in influenza virus infection.[/h] Falcon A[SUP]1[/SUP], Cuevas MT[SUP]2[/SUP], Rodriguez-Frandsen A[SUP]3[/SUP], Reyes N[SUP]2[/SUP], Pozo F[SUP]2[/SUP], Moreno S[SUP]2[/SUP], Ledesma J[SUP]2[/SUP], Mart?nez-Alarc?n J[SUP]4[/SUP], Nieto A[SUP]5[/SUP], Casas I[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza epidemics affect all age groups, although children, the elderly, and those with underlying medical conditions are the most severely affected. Whereas co-morbidities are present in 50% of fatal cases, 25-50% of deaths are of apparently healthy individuals. This suggests underlying genetic determinants that govern infection severity. Although some viral factors that contribute to influenza disease are known, the role of host genetic factors remains undetermined. Data for small cohorts of influenza-infected patients are contradictory regarding the potential role of chemokine receptor 5 deficiency (CCR5-Δ32 mutation, a 32-base pair deletion in CCR5) in the outcome of influenza virus infection. We tested 171 respiratory samples from influenza patients (2009 pandemic) for CCR5-Δ32 and evaluated its correlation with patient mortality. CCR5-Δ32 patients (17.4%) showed a higher mortality rate than wild-type individuals (4.7%; p = 0.021), which indicates that CCR5-Δ32 patients are at higher risk than the normal population of fatal outcome in influenza infection.
PMID: 25918237 [PubMed - as supplied by publisher]