Mary Wilson
Well-known member
Correspondence / Published: 17 June 2021
Zahin Amin-Chowdhury
Shamez N. Ladhani
DOI: https://doi.org/10.1038/s41591-021-01402-w
To the Editor—Early reports of persisting symptoms following COVID-19 signaled a debilitating long-term fate for an undetermined proportion of people who survive COVID-19[SUP]1[/SUP]. A year later, there is no consensus on a name, a duration or symptoms for this syndrome, known alternatively as ‘post-acute COVID-19’, ‘post-COVID syndrome’ or ‘long COVID’. At the time of this writing, between 170 and 205 persistent, intermittent and relapsing symptoms have been attributed to long COVID, lasting anywhere between 4 weeks and >1 year after infection with the coronavirus SARS-CoV-2[SUP]2[/SUP]. Many of the self-reported symptoms, such as intermittent headaches or tiredness, are nonspecific and prevalent in the general population, whereas others, such as an inability to yawn or chapped lips, are biologically implausible, and are unlikely to meet Bradford Hill criteria for causality[SUP]3[/SUP].
The finding that some patients develop post-infectious complications or neuropsychological sequelae as a consequence of infection and inflammation of body organ systems, through as-yet poorly understood pathophysiological mechanisms, is not unexpected and has been reported after other infectious diseases, particularly glandular fever and influenza. It is, however, the projected burden that is unprecedented. ...
https://www.nature.com/articles/s41...ted&code=b0138548-259f-438d-9d6a-529c85a99b7c
Zahin Amin-Chowdhury
Shamez N. Ladhani
DOI: https://doi.org/10.1038/s41591-021-01402-w
To the Editor—Early reports of persisting symptoms following COVID-19 signaled a debilitating long-term fate for an undetermined proportion of people who survive COVID-19[SUP]1[/SUP]. A year later, there is no consensus on a name, a duration or symptoms for this syndrome, known alternatively as ‘post-acute COVID-19’, ‘post-COVID syndrome’ or ‘long COVID’. At the time of this writing, between 170 and 205 persistent, intermittent and relapsing symptoms have been attributed to long COVID, lasting anywhere between 4 weeks and >1 year after infection with the coronavirus SARS-CoV-2[SUP]2[/SUP]. Many of the self-reported symptoms, such as intermittent headaches or tiredness, are nonspecific and prevalent in the general population, whereas others, such as an inability to yawn or chapped lips, are biologically implausible, and are unlikely to meet Bradford Hill criteria for causality[SUP]3[/SUP].
The finding that some patients develop post-infectious complications or neuropsychological sequelae as a consequence of infection and inflammation of body organ systems, through as-yet poorly understood pathophysiological mechanisms, is not unexpected and has been reported after other infectious diseases, particularly glandular fever and influenza. It is, however, the projected burden that is unprecedented. ...
https://www.nature.com/articles/s41...ted&code=b0138548-259f-438d-9d6a-529c85a99b7c