Pathfinder
Editor, Senior Moderator
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[h=1]Zika virus in semen of a patient returning from a non-epidemic area[/h] Jean Michel Mansuy
, Christophe Pasquier
, Myriam Daudin
, Sabine Chapuy-Regaud
, Nathalie Moinard
, Christine Chevreau
, Jacques Izopet
, Catherine Mengelle
, Louis Bujan
DOI: http://dx.doi.org/10.1016/S1473-3099(16)30153-0
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Article Info[/h]
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We report the case of a 27-year-old man who had had a mass in the popliteal area for several months, and was diagnosed with a monophasic grade 2 synovial cell sarcoma in mid-February, 2016. A combination of treatment, including aggressive chemotherapy, was planned for the beginning of April, and the patient was therefore sent to the local centre for the study and conservation of human sperm and ova.
French guidelines on Zika virus infection risk during fertility preservation have been designed for patients returning from epidemic areas. They recommend that fertility preservation management should be delayed for up to 28 days after travel and that semen should be checked for Zika virus within 6 months of travel.
The patient therefore underwent a systematic medical interview, which revealed that he had recently travelled to southeast Asia. Although he had not travelled within any epidemic areas, samples of blood, urine, and semen were collected on March 9, 2016, and sent to the department of virology at Toulouse University Hospital for Zika virus diagnosis.
No traces of the Zika virus genome were detected in the blood or urine samples, but Zika virus RNA was detected twice in the semen. The viral load was 4800 copies per mL (RealStar Zika Virus RT-PCR kit 1?0, Altona Diagnostics, Hamburg, Germany) and the strain that was detected clustered with the Asian genotype group on a 376 nucleotide fragment from the NS5 region. The semen characteristics were in the normal range.
A second medical interview found that the patient had been travelling in Thailand between Oct 18 and Nov 30, 2015, and had been bitten by mosquitos, but had not been exposed to any known risk of Zika virus transmission since his return to France. Mild symptoms (asthenia, myalgia, and conjunctivitis) compatible with Zika virus infection appeared on Dec 6, 2015, and lasted for a few days. Zika virus was detected in the semen 93 days after the onset of the Zika fever symptoms.
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http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(16)30153-0/fulltext
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Volume 16, No. 8, p894?895, August 2016
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[FONT="] Correspondence
[/FONT]
[h=1]Zika virus in semen of a patient returning from a non-epidemic area[/h] Jean Michel Mansuy
, Christophe Pasquier
, Myriam Daudin
, Sabine Chapuy-Regaud
, Nathalie Moinard
, Christine Chevreau
, Jacques Izopet
, Catherine Mengelle
, Louis Bujan
DOI: http://dx.doi.org/10.1016/S1473-3099(16)30153-0
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Article Info[/h] [/FONT]
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- Summary
- [h=3]Full Text[/h]
- References
We report the case of a 27-year-old man who had had a mass in the popliteal area for several months, and was diagnosed with a monophasic grade 2 synovial cell sarcoma in mid-February, 2016. A combination of treatment, including aggressive chemotherapy, was planned for the beginning of April, and the patient was therefore sent to the local centre for the study and conservation of human sperm and ova.
French guidelines on Zika virus infection risk during fertility preservation have been designed for patients returning from epidemic areas. They recommend that fertility preservation management should be delayed for up to 28 days after travel and that semen should be checked for Zika virus within 6 months of travel.
The patient therefore underwent a systematic medical interview, which revealed that he had recently travelled to southeast Asia. Although he had not travelled within any epidemic areas, samples of blood, urine, and semen were collected on March 9, 2016, and sent to the department of virology at Toulouse University Hospital for Zika virus diagnosis.
No traces of the Zika virus genome were detected in the blood or urine samples, but Zika virus RNA was detected twice in the semen. The viral load was 4800 copies per mL (RealStar Zika Virus RT-PCR kit 1?0, Altona Diagnostics, Hamburg, Germany) and the strain that was detected clustered with the Asian genotype group on a 376 nucleotide fragment from the NS5 region. The semen characteristics were in the normal range.
A second medical interview found that the patient had been travelling in Thailand between Oct 18 and Nov 30, 2015, and had been bitten by mosquitos, but had not been exposed to any known risk of Zika virus transmission since his return to France. Mild symptoms (asthenia, myalgia, and conjunctivitis) compatible with Zika virus infection appeared on Dec 6, 2015, and lasted for a few days. Zika virus was detected in the semen 93 days after the onset of the Zika fever symptoms.
...
http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(16)30153-0/fulltext
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