"Influenza-Induced Mania."
The Journal of Neuropsychiatry and Clinical Neurosciences, 28(1), pp. e17?e18
o the Editor: According to the Centers for Disease Control and Prevention, 5%−20% of the US population is infected by the influenza virus annually. The influenza virus commonly affects the respiratory system, but the neuropsychiatric symptoms are often underappreciated. Karl Menninger was one of the first to link neuropsychiatric symptoms in 100 patients with influenza who were admitted with behavioral changes in 1918.[SUP]
1[/SUP] The famous 1918 strain of influenza was associated with von Economo?s encephalitis lethargica and postencephalitic parkinsonism.[SUP]
2[/SUP] In the 1960s, pediatric cases of influenza infections were associated with Reye?s syndrome.[SUP]
2[/SUP] The influenza A 2009 strain was coupled with an increase in the number of serious cases of acute necrotizing encephalopathy.[SUP]
2[/SUP] Primary neurological manifestations appear more commonly in children but can emerge in adults with symptoms of headaches, numbness, paresthesia, weakness, vertigo, decreased alertness, seizures, encephalopathy, and meningismus. Other less common neurologic complications include Guillain-Barr? syndrome, aseptic meningitis, and transverse myelitis.[SUP]
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3[/SUP] The influenza virus has also been associated with acute psychosis and the onset of a manic episode.[SUP]
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6[/SUP] The following report illustrates a case of a patient with suspected influenza-induced mania.
