tetano
Editor, Senior Moderator
BMC Nephrol. 2017 Mar 20;18(1):96. doi: 10.1186/s12882-017-0512-y.
[h=1]Case report - atypical hemolytic uremic syndrome triggered by influenza B.[/h] Kobbe R[SUP]1[/SUP], Schild R[SUP]2[/SUP], Christner M[SUP]2[/SUP], Oh J[SUP]2[/SUP], Loos S[SUP]2[/SUP], Kemper MJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.
[h=4]CASE PRESENTATION:[/h] A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.
[h=4]CONCLUSION:[/h] Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.
[h=4]KEYWORDS:[/h] Atypical HUS; HUS; Hemolytic uremic syndrome; Influenza; Influenza vaccination; Quadrivalent; aHUS
PMID: 28320387 PMCID: PMC5358041 DOI: 10.1186/s12882-017-0512-y
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[h=1]Case report - atypical hemolytic uremic syndrome triggered by influenza B.[/h] Kobbe R[SUP]1[/SUP], Schild R[SUP]2[/SUP], Christner M[SUP]2[/SUP], Oh J[SUP]2[/SUP], Loos S[SUP]2[/SUP], Kemper MJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.
[h=4]CASE PRESENTATION:[/h] A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.
[h=4]CONCLUSION:[/h] Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.
[h=4]KEYWORDS:[/h] Atypical HUS; HUS; Hemolytic uremic syndrome; Influenza; Influenza vaccination; Quadrivalent; aHUS
PMID: 28320387 PMCID: PMC5358041 DOI: 10.1186/s12882-017-0512-y
Free full text