tetano
Editor, Senior Moderator
Case Rep Nephrol Dial
. 2022 Nov 28;12(3):248-254.
doi: 10.1159/000528029. eCollection 2022 Sep-Dec.
Tip Lesion Variant of Focal and Segmental Glomerulosclerosis in a COVID-19 Patient
Rita Serra Afonso[SUP] 1 [/SUP], Roberto Calças Marques[SUP] 1 [/SUP], Henrique Borges[SUP] 1 [/SUP], Eduarda Carias[SUP] 1 [/SUP], Ana Teresa Domingos[SUP] 1 [/SUP], Ana Cabrita[SUP] 1 2 [/SUP], Sandra Sampaio[SUP] 1 [/SUP], Ana Paula Silva[SUP] 1 2 [/SUP]
Affiliations
Abstract
Acute kidney injury is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathologic findings are continually being reported, showing a probably multifactorial etiology. The authors present a case of a patient diagnosed with a tip lesion variant of focal segmental glomerulosclerosis (FSGS) in the setting of COVID-19. A 43-year-old African American female with no known renal disease presented to the emergency department with a 6-day history of fatigue, headache, hypoageusia, myalgia, cough, nausea, and vomiting. Laboratory tests confirmed SARS-CoV-2 infection. During hospitalization, there was a progressive decline in kidney function and evidence of nephrotic-range proteinuria without nephrotic syndrome. Biopsy specimen showed a tip lesion variant of FSGS. Genetic test revealed a homozygous variant of uncertain clinical significance (c.397G>A [p.V133M]) in the epithelial membrane protein 2 (EMP2) gene. To our knowledge, this is the first case report of a tip lesion in a COVID-19 patient with no renal history. More studies are warranted to define susceptible groups and identify the detailed mechanisms of COVID-19-related kidney disease that would allow for specific management of this complication.
Keywords: Acute kidney injury; Proteinuria; Renal biopsy; SARS-CoV-2.
. 2022 Nov 28;12(3):248-254.
doi: 10.1159/000528029. eCollection 2022 Sep-Dec.
Tip Lesion Variant of Focal and Segmental Glomerulosclerosis in a COVID-19 Patient
Rita Serra Afonso[SUP] 1 [/SUP], Roberto Calças Marques[SUP] 1 [/SUP], Henrique Borges[SUP] 1 [/SUP], Eduarda Carias[SUP] 1 [/SUP], Ana Teresa Domingos[SUP] 1 [/SUP], Ana Cabrita[SUP] 1 2 [/SUP], Sandra Sampaio[SUP] 1 [/SUP], Ana Paula Silva[SUP] 1 2 [/SUP]
Affiliations
- PMID: 36654985
- PMCID: PMC9841791
- DOI: 10.1159/000528029
Abstract
Acute kidney injury is a common complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Several pathologic findings are continually being reported, showing a probably multifactorial etiology. The authors present a case of a patient diagnosed with a tip lesion variant of focal segmental glomerulosclerosis (FSGS) in the setting of COVID-19. A 43-year-old African American female with no known renal disease presented to the emergency department with a 6-day history of fatigue, headache, hypoageusia, myalgia, cough, nausea, and vomiting. Laboratory tests confirmed SARS-CoV-2 infection. During hospitalization, there was a progressive decline in kidney function and evidence of nephrotic-range proteinuria without nephrotic syndrome. Biopsy specimen showed a tip lesion variant of FSGS. Genetic test revealed a homozygous variant of uncertain clinical significance (c.397G>A [p.V133M]) in the epithelial membrane protein 2 (EMP2) gene. To our knowledge, this is the first case report of a tip lesion in a COVID-19 patient with no renal history. More studies are warranted to define susceptible groups and identify the detailed mechanisms of COVID-19-related kidney disease that would allow for specific management of this complication.
Keywords: Acute kidney injury; Proteinuria; Renal biopsy; SARS-CoV-2.