Case fatality rates of Ebola virus diseases: A meta-analysis of World Health Organization data

Laidback Al · Sep 20, 2014

Case fatality rates of Ebola virus diseases: A meta-analysis of World Health Organization data
A. Lefebvre, C. Fiet, C. Belpois-Duchamp, M. Tiv, K. Astruc, L.S. Aho Gl?l?

Service d??pid?miologie et d?hygi?ne hospitali?res, h?pital d?enfants, CHU, 14, rue Paul-Gaffarel, BP 77908, 21079 Dijon cedex, France

Received 15 April 2014, Revised 20 June 2014, Accepted 6 August 2014, Available online 2 September 2014, Original Research Article In Press, Corrected Proof

Med Mal Infect. 2014 Sep 2. pii: S0399-077X(14)00208-X. doi: 10.1016/j.medmal.2014.08.005. [Epub ahead of print]

Abstract

Objective
Our objective was to estimate the case fatality rates of Zaire, Sudan, and Bundibugyo Ebola species, responsible for sometimes-lethal hemorrhagic fevers.

Methods
We performed a meta-analysis of World Health Organization data on outbreaks of infections due to these species.

Results
Twenty outbreaks, including the current one, were studied. The estimated case fatality rate was 65.4% (CI 95% [54.6%; 75.5%]) and varied among the outbreaks. A species effect was identified, with a higher case fatality rate for the Zaire species than for Sudan and Bundibugyo species. The case fatality rate of the Zaire species tended to decrease with time.

Conclusion
The case fatality rates associated with these 3 species was high. A great variability was observed. It could be explained partly by a species effect and by the decrease of Zaire species case fatality rate, with time.

http://www.sciencedirect.com/science/article/pii/S0399077X1400208X
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Case fatality rates of Ebola virus diseases: A meta-analysis of World Health Organization data

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