tetano
Editor, Senior Moderator
Clin Infect Dis. 2016 Aug 2. pii: ciw512. [Epub ahead of print]
[h=1]Case-control study of vaccine effectiveness in preventing laboratory-confirmed influenza hospitalizations in older adults, United States, 2010-11.[/h] Havers FP[SUP]1[/SUP], Sokolow L[SUP]2[/SUP], Shay DK[SUP]1[/SUP], Farley MM[SUP]3[/SUP], Monroe M[SUP]4[/SUP], Meek J[SUP]5[/SUP], Kirley PD[SUP]6[/SUP], Bennett NM[SUP]7[/SUP], Morin C[SUP]8[/SUP], Aragon D[SUP]9[/SUP], Thomas A[SUP]10[/SUP], Schaffner W[SUP]11[/SUP], Zansky SM[SUP]12[/SUP], Baumbach J[SUP]13[/SUP], Ferdinands J[SUP]2[/SUP], Fry AM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Older adults are at increased risk of influenza-associated complications, including hospitalization, but influenza vaccine effectiveness (VE) data are limited for this population. We conducted a case-control study to estimate VE to prevent laboratory-confirmed influenza hospitalizations among adults aged ≥50 years in eleven U.S. Emerging Infections Program (EIP) hospitalization surveillance sites.
[h=4]METHODS:[/h] Cases were RT-PCR-confirmed influenza infections in adults ≥50 years old hospitalized during the 2010-11 influenza season identified through EIP surveillance. Community controls, identified through home telephone lists, were matched by age group (+/- 5 years), county, and month of case hospitalization. Vaccination status was determined by self-report (with location and date) or medical records. Conditional logistic regression models were used to calculate adjusted VE (aVE) estimates [100 x (1 - adjusted odds ratio)] adjusting for sex, race, socioeconomic factors, smoking, chronic medical conditions, recent respiratory hospitalizations, and functional status.
[h=4]RESULTS:[/h] Among case-patients, 205/368 (55%) were vaccinated; 489/773 (63%) of controls were vaccinated. Case-patients were more likely to be persons of non-white race, with ≥2 chronic health conditions, with a recent hospitalization for a respiratory condition, with an income <$35,000, and report a lower functional status score (P-values <0.01 for all). Adjusted VE was 56.8% (95% confidence interval (CI): 34.1%-71.7%) and was similar by age, including adults ≥75 years [aVE 57.3% (95% CI 15.9%-78.4%)].
[h=4]CONCLUSION:[/h] During 2010-11, influenza vaccination was associated with a significant reduction of the risk of laboratory-confirmed influenza hospitalization among adults aged ≥50 years regardless of age group.
Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 27486114 DOI: 10.1093/cid/ciw512
[PubMed - as supplied by publisher]
[h=1]Case-control study of vaccine effectiveness in preventing laboratory-confirmed influenza hospitalizations in older adults, United States, 2010-11.[/h] Havers FP[SUP]1[/SUP], Sokolow L[SUP]2[/SUP], Shay DK[SUP]1[/SUP], Farley MM[SUP]3[/SUP], Monroe M[SUP]4[/SUP], Meek J[SUP]5[/SUP], Kirley PD[SUP]6[/SUP], Bennett NM[SUP]7[/SUP], Morin C[SUP]8[/SUP], Aragon D[SUP]9[/SUP], Thomas A[SUP]10[/SUP], Schaffner W[SUP]11[/SUP], Zansky SM[SUP]12[/SUP], Baumbach J[SUP]13[/SUP], Ferdinands J[SUP]2[/SUP], Fry AM[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Older adults are at increased risk of influenza-associated complications, including hospitalization, but influenza vaccine effectiveness (VE) data are limited for this population. We conducted a case-control study to estimate VE to prevent laboratory-confirmed influenza hospitalizations among adults aged ≥50 years in eleven U.S. Emerging Infections Program (EIP) hospitalization surveillance sites.
[h=4]METHODS:[/h] Cases were RT-PCR-confirmed influenza infections in adults ≥50 years old hospitalized during the 2010-11 influenza season identified through EIP surveillance. Community controls, identified through home telephone lists, were matched by age group (+/- 5 years), county, and month of case hospitalization. Vaccination status was determined by self-report (with location and date) or medical records. Conditional logistic regression models were used to calculate adjusted VE (aVE) estimates [100 x (1 - adjusted odds ratio)] adjusting for sex, race, socioeconomic factors, smoking, chronic medical conditions, recent respiratory hospitalizations, and functional status.
[h=4]RESULTS:[/h] Among case-patients, 205/368 (55%) were vaccinated; 489/773 (63%) of controls were vaccinated. Case-patients were more likely to be persons of non-white race, with ≥2 chronic health conditions, with a recent hospitalization for a respiratory condition, with an income <$35,000, and report a lower functional status score (P-values <0.01 for all). Adjusted VE was 56.8% (95% confidence interval (CI): 34.1%-71.7%) and was similar by age, including adults ≥75 years [aVE 57.3% (95% CI 15.9%-78.4%)].
[h=4]CONCLUSION:[/h] During 2010-11, influenza vaccination was associated with a significant reduction of the risk of laboratory-confirmed influenza hospitalization among adults aged ≥50 years regardless of age group.
Published by Oxford University Press for the Infectious Diseases Society of America 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PMID: 27486114 DOI: 10.1093/cid/ciw512
[PubMed - as supplied by publisher]